A5087419852- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Drug-Induced Hepatotoxicity and Protection
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Cytokine Signaling Pathways and Interactions
- Biomedical Ethics and Regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Hepatitis C virus research
- Melanoma and MAPK Pathways
- Monoclonal and Polyclonal Antibodies Research
- Nanoplatforms for cancer theranostics
- Pluripotent Stem Cells Research
- Liver Disease Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Hepatitis B Virus Studies
- 3D Printing in Biomedical Research
Vertex Pharmaceuticals (United States)
2007-2017
Northeastern University
2003-2004
While several therapeutic options exist, the need for more effective, safe, and convenient treatment a variety of autoimmune diseases persists. Targeting Janus tyrosine kinases (JAKs), which play essential roles in cell signaling responses can contribute to aberrant immune function associated with disease, has emerged as novel attractive approach development new disease therapies. We screened our compound library against JAK3, key kinase cells, identified multiple scaffolds showing good...
Tissue chips are poised to deliver a paradigm shift in drug discovery. By emulating human physiology, these have the potential increase predictive power of preclinical modeling, which turn will move pharmaceutical industry closer its aspiration clinically relevant and ultimately animal-free Despite tremendous science innovation invested tissue chips, significant challenges remain be addressed enable their routine adoption into industrial laboratory. This article describes main steps that...
Mixed micelles were prepared from poly(ethyleneglycol)-distearyl phosphoethanolamine (PEG2000-PE) and egg phosphatidylcholine. The covalently modified with the nucleosome-specific monoclonal antibody 2C5 known to recognize bind a variety of tumor cells via their surface-bound nucleosomes. Covalent attachment was performed micelle-incorporated PEG-PE distal terminus PEG block activated p-nitrophenylcarbonyl group (pNP-PEG-PE). Micelle surface-attached maintained its specific activity....
Understanding hepatitis C virus (HCV) replication has been limited by access to serial samples of liver, the primary site viral replication. Our understanding how HCV replicates and develops drug-resistant variants in liver is limited. We studied 15 patients chronically infected with genotype 1 treated telaprevir (TVR)/pegylated-interferon alpha/ribavirin. Hepatic fine needle aspiration was performed before treatment at hour 10, days 4 15, week 8 after initiation antiviral therapy. measured...
Context: VX-702 is a novel p38 mitogen-activated protein kinase inhibitor being developed to treat rheumatoid arthritis. Objective: To characterize the renal excretion profile of using isolated perfused rat kidney (IPRK) model. Methods: Studies were performed assess dose linearity and evaluate effect inhibitors organic anion (probenecid) cation (cimetidine) transport systems on disposition. was studied over range doses targeting concentrations between 100 600 ng/mL. (600 ng/mL) also...