A5101454269- Cytokine Signaling Pathways and Interactions
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Complement system in diseases
- Virus-based gene therapy research
- Neurological Disease Mechanisms and Treatments
- CAR-T cell therapy research
- Sentiment Analysis and Opinion Mining
- Synthesis and biological activity
- Image Processing and 3D Reconstruction
- Soil erosion and sediment transport
- Sexual function and dysfunction studies
- Cholesterol and Lipid Metabolism
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects of Natural Compounds
- Posttraumatic Stress Disorder Research
- Plant pathogens and resistance mechanisms
- Cancer survivorship and care
- Protein Tyrosine Phosphatases
- Healthcare Decision-Making and Restraints
- Inflammatory Bowel Disease
- Marriage and Sexual Relationships
- Adenosine and Purinergic Signaling
Third Xiangya Hospital
2023-2025
Central South University
2023-2025
Guangzhou Development Zone Hospital
2024-2025
Chengdu University of Technology
2024
Experimental Center of Subtropical Forestry
2024
Chinese Academy of Forestry
2024
South China Normal University
2024
Hainan Medical University
2022
Hainan General Hospital
2022
Guangdong Medical College
2018-2022
While several therapeutic options exist, the need for more effective, safe, and convenient treatment a variety of autoimmune diseases persists. Targeting Janus tyrosine kinases (JAKs), which play essential roles in cell signaling responses can contribute to aberrant immune function associated with disease, has emerged as novel attractive approach development new disease therapies. We screened our compound library against JAK3, key kinase cells, identified multiple scaffolds showing good...
注意力的改变是 导致政府决策发生变化的直接原因之一。本文参考王印红等 [15] 的研究方法，通过引入 "政府生态环境注意力"概念来衡量政府决策者对环境问题的关注程度。申伟宁等 [16] 基于 京津冀政府工作报告，研究了生态环境注意力的波动趋势以及其对环境治理绩效的影响 效应。张慧智等
Abstract Background There is limited consensus on physical activity recommendations for inflammatory bowel disease (IBD) patients due to insufficient high-quality evidence. We investigated the associations of accelerometer-measured moderate-to-vigorous (MVPA) with resection risk and mortality among affected individuals. Methods collected data from 1,303 UK Biobank participants IBD diagnosis device-measured activity. MVPA was classified based measured by wrist-worn accelerometers over a 7-day...
Aim: This study designed a three‐step teaching method of “online–simulation–bedside,” which was applied to the cardiopulmonary resuscitation skills in team emergency and critical care nursing interns, effectiveness this evaluated using Kirkpatrick model. Background: Mastering knowledge techniques is necessary for interns fulfill their roles. At present, first aid awareness rescue are not optimistic. Training programs can improve ability students, but most them only evaluate changes before...
ABSTRACT Our findings reported a confusing but interesting clinical practice. In our study, three spike signals are observed during stable pacing periods, with fixed spikes occurring the AV delay at 180 ms intervals, excluding other operation types such as CRT and His bundle pacing.
A series of pyrido[2,3-d]pyrimidin-5-ones has been synthesized and evaluated as inhibitors the kinase domain macrophage colony-stimulating factor-1 receptor (FMS). FMS may be useful in treating rheumatoid arthritis other chronic inflammatory diseases. Structure-based optimization lead amide analogue 10 led to hydroxamate 37, which possessed excellent potency an improved pharmacokinetic profile. During phase streptococcal cell wall-induced rats, compound 37 (10, 3, 1 mg/kg) was highly...
ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTBradykinin B1 Receptor Antagonists as Potential Therapeutic Agents for PainHui Huang and Mark R. Player*View Author Information Johnson & Pharmaceutical Research Development, Welsh McKean Roads, Spring House, Pennsylvania 19477-0776*To whom correspondence should be addressed. Phone: 215-628-7860. Fax: 215-540-4616. E-mail: [email protected]Cite this: J. Med. Chem. 2010, 53, 15, 5383–5399Publication Date (Web):April 6, 2010Publication History...
Abstract The lack of efficient T‐cell infiltration tumors is a major obstacle to successful adoptive therapy. We have previously demonstrated that adenovirus (AdV)‐mediated transgene lymphotactin (Lptn) or IP‐10 expression in can significantly enhance tumor infiltration. In this study, active OVA‐specific CD8 + T cells were prepared by coculturing naive from transgenic OT I mice with OVA‐I peptide‐pulsed dendritic vitro . These XCR‐1‐ and CXCR3‐expressing predominantly secreted IFN‐γ...
Multidrug resistance protein-1 (MRP1) belongs to subfamily C of the ATP-binding cassette transporters, and exports leukotriene C4 organic anions including fluorescent calcium indicator indo-1. The observation that leukocytes from patients with an autoimmune disease exported indo-1 at a higher rate than controls prompted hypothesis MRP1 contributes function activated cells. To test this, we defined expression on resting human T cells, determined whether cell activation is dependent upon...
CC chemokine ligand 18 (CCL18) is a chemotactic cytokine involved in the pathogenesis and progression of various cancers. Our previous research showed that expression CCL18 obviously higher non-small cell lung cancer (NSCLC) than adjacent normal tissues, suggesting its role NSCLC.We further examined serum level 80 NSCLC patients with enzyme-linked immunosorbent assay simultaneously analyzed survival curve these by Kaplan-Meier method, then utilized log-rank test to evaluate correlation...
Abstract During the Corona Virus Disease 2019 (COVID-19) pandemic, both high levels of post-traumatic stress and positive personal changes, a phenomenon known as growth (PTG), were experienced by some people. What remains unknown are constructs facilitators PTG during COVID-19 pandemic. Therefore, this study uses grounded theory methodology to elucidate behavioral cognitional dimensions in Chinese college students. Twenty-four individual semi-structured interviews conducted with students who...
To identify symptom clusters and examine their association with health-related quality of life.Multiple myeloma patients undergoing chemotherapy suffer from disease symptoms adverse effects during the course disease. However, single management has little effect, for these remains challenging. Symptom open a new perspective provide important clues management.A cross-sectional study.Participants were invited to complete Chinese version Memorial Assessment Scale Quality Life Questionnaire-core...
Aim. This study aims to identify the factors that influence humanistic practice ability, validate relationship among social support, empathy, self-efficacy, and practice, provide reference basis for developing intervention measures. Background. Cultivating ability in clinical nurses is essential improving quality of nursing care. Methods. From February March 2022, a cross-sectional survey was conducted top three hospitals central China. The used self-designed questionnaire ascertain general...
The slice thickness of MR imaging may remarkably degrade the clarity 3D lesion images within through-plane slices (coronal or sagittal views) so as to influence performance characterization. To alleviate problem, we propose an end-to-end super-resolution and self-attention framework based on Generative adversarial networks (GAN) for improving malignancy characterization hepatocellular carcinoma (HCC). Specifically, a subnetwork is designed enhance low-resolution patches coronal views high...
Although anterior cruciate ligament reconstruction (ACLR) can restore the stability and function of knee joint, patellofemoral joint cartilage damage still progresses. Currently, clinically important factors that lead to progression articular are not fully understood.To investigate affect after ACLR.Cohort study; Level evidence, 2.Among 160 patients who underwent ACLR between January 2015 December 2019, authors evaluated 129 for at least 1 year surgery. Within week before last follow-up,...