A5071931643- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Sex work and related issues
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Adolescent Sexual and Reproductive Health
- Herpesvirus Infections and Treatments
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Pneumocystis jirovecii pneumonia detection and treatment
- Animal Disease Management and Epidemiology
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Vaccine Coverage and Hesitancy
- HIV-related health complications and treatments
- Animal Virus Infections Studies
- Virology and Viral Diseases
Guangdong Medical College
2023-2025
Jining Medical University
2024-2025
Zhejiang University
2016-2025
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2018-2025
Taizhou Second People's Hospital
2025
Key Laboratory of Guangdong Province
2025
Chinese Center For Disease Control and Prevention
2015-2024
National Center for AIDS/STD Control and Prevention,China CDC
2015-2024
Guangxi Center for Disease Prevention and Control
2015-2024
State Key Laboratory of Infectious Disease Prevention and Control
2014-2024
Background China is experiencing a dynamic HIV/AIDS epidemic. While serology based surveillance systems have reported the spread of HIV/AIDS, detailed tracking its transmission in populations and regions not possible without mapping it at molecular level. We therefore conducted nationwide epidemiology survey across country. Methods HIV-1 genotypes were determined from 1,408 HIV-positive persons newly diagnosed 2006. The prevalence each genotype was estimated by weighting genotype's province-...
Based on the official data modeling, this paper studies transmission process of Corona Virus Disease 2019 (COVID-19). The error between model and curve is quite small. At same time, it realized forward prediction backward inference epidemic situation, relevant analysis help countries to make decisions.
A molecular epidemiology study was conducted among more than 100 human immunodeficiency virus type 1 (HIV-1) subtype C seropositive intravenous drug users (IDUs) from China. Genotyping based on the envelope C2V3 coding region revealed highest homology of most prevalent strains circulating throughout China to sequences Indian origin. Based these results, a virtually full-length genome representing class clade directly amplified peripheral blood mononuclear cells selected HIV-infected IDU and...
A new collaborative model of research is needed to increase resources, prioritize the R (ii) pace, reduce overlap, and more systematically explore elements delivery systems for vaccines; (iii) use common standards prompt comparative testing vaccine candidates; (iv) expand resources manufacturing candidates speed their in human trials; (v) capacity international clinical trials focus this effort toward quickly measuring effectiveness protection as prototype are identified.
Objectives: We sought to comprehensively analyze the origin, transmission patterns and sub-epidemic clusters of HIV-1 CRF01_AE strains in China. Methods: Available samples indentified national molecular epidemiologic surveys were used generate near full-length genome (NFLG) sequences. The new globally available NFLG sequences subjected phylogenetic Bayesian clock analyses, combined with data elucidate history Results: generated 75 from various risk populations covering all major epidemic...
Fullerenol, which self-assembles into virus-sized nanoparticles, is designed as a dual-functional nanoadjuvant to generate comparable immune responses the HIV DNA vaccine. It shows promising adjuvant activity via various immunization routes, decreasing antigen dosage and frequency while maintaining immunity levels inducing TEM-biased combat infection at early stage. The underlying mechanisms by fullerenol-based formulation induces above-mentioned polyvalent are involved in activating...
In Brief Background: Little is known about risk of HIV and other STDs among men who have sex with (MSM) in China. Objective: To survey the prevalence factors syphilis evaluate correlation two infections MSM Chinese capital city. Methods: A community-based sample 526 was recruited 2005 through Internet advertising, community outreach, peer referring. Interviewer-administered interviews were conducted to collect information on demographics sexual behaviors, blood samples collected test for...
Abstract Background Men who have sex with men (MSM) are much more likely to be infected HIV than the general population. China has a sizable population of MSM, including gay, bisexual men, money boys and some rural workers. So reducing infection in this is an important component national HIV/AIDS prevention control program. Methods We develop mathematical model using sex-role-preference framework predict MSM evaluate different intervention strategies. Results An analytic formula for basic...
Background: Transmission of HIV drug resistance (TDR) gives rise to reduced efficacy initial antiretroviral treatment and has become a public health concern. Methods: A nationwide survey on TDR was conducted in therapy-naive HIV-1-infected individuals from September 2004 October 2005 China. Drug genotyping performed subjects' plasma samples. mutations were determined scored by Stanford Resistance algorithm. Results: Sequences obtained 676 individuals, whom 61.2% former blood donors, 17.3%...
Abstract To determine the origin and evolutionary history of two predominant closely-related circulating recombinant forms (CRF07_BC CRF08_BC), structures phylogenies 7 unique comprised subtypes B’ (Thai B linage) C (designated URFs_BC) from archival specimens injection drug users (IDUs) collected in 1996 to 1998 western Yunnan 4 with B’/C recombinants recently identified nCRFs_BC) China were compared those CRF07_BC CRF08_BC. The results showed that 5 URFs_BC all nCRFs_BC shared...
Objective: To investigate the origin and evolutionary history of HIV-1 subtype B′ responsible for epidemic among injecting drug users (IDUs), former plasma donors (FPDs) subsequent heterosexual transmission in China. Methods: A total 33 sequences near full-length genomes (NFLGs) sampled during 1998–2009 11 provinces across China were determined. The NFLGs subjected to Bayesian molecular clock analyses estimate time most recent common ancestors (tMRCAs) reconstitute time–space process...
CRF55_01B is a relatively "young" HIV strain. At present, we do not know much about its transmission characteristics in China. So, to describe the of strain among provinces and infected people, analyze reasons for rapid epidemic China, total 1237 subjects with from 31 spanning period 12 years 2007 2018 were enrolled this study. By constructing molecular network Bayesian correlation analysis, found that increased exponentially 2005 2009 after origin Shenzhen, rapidly 2010. began spread other...
The objective of this study was to investigate the prevalence and risk factors syphilis infection among female sex workers in a southwestern Chinese city along drug trafficking route.From December 2004 January 2005, 343 (FSWs) were recruited through community outreach peer referring. Confidential questionnaire interviews administered collect information on sexual other sexually transmitted diseases/HIV behaviors. Cervical blood samples collected test for HIV antibodies Neisseria gonorrhoeae...
Objectives: To investigate risk factors related to HIV infection and the prevalence of selected infections, especially sexually transmitted infections (STI) among men who have sex with (MSM). Design: A cross-sectional study including questionnaire blood sample collection. Methods: Between January 2005 December 2006, 753 MSM were recruited through voluntary counselling testing (VCT) clinic at Chaoyang District Centers for Disease Control Prevention in Beijing. Sera samples collected tested...
Objectives Undiagnosed HIV presents great potential for the spread of infection. The authors identify prevalence and correlates never testing being unaware infection in Beijing men who have sex with (MSM). Methods Cross-sectional biological behavioural survey using respondent-driven sampling; 500 MSM were included. Results was 7.2% 86.1% their infection; 33.2% had tested. Never associated lower educational (adjusted odds ratio (AOR) 1.6, 95% CI (CI) 1.1 to 2.5), living ≤3 years (AOR 1.5, 1.0...
In Brief Background HIV testing is the gateway for prevention and care. We explored factors associated with among Chinese men who have sex (MSM). Methods Chongqing City, we recruited 492 MSM in 2010 using respondent-driven sampling a cross-sectional study. Computer-assisted self-interviews were conducted to collect information on history of testing. Results Only 58% participants reported ever having taken an test. Men had college degree (adjusted odds ratio [AOR], 1.7; 95% confidence...
We assessed HIV prevalence and associated behaviors risk factors among men who have sex with (MSM) in Beijing, China. Five hundred MSM were recruited for a biological behavioral survey using respondent-driven sampling (RDS) 2009. Serologic specimens tested markers of syphilis infection. A computer-assisted personal interview (CAPI) administered questionnaire gathered information including demographic characteristics, sexual behaviors, testing, social norms concerning condom use. The adjusted...
Diagnosis of HIV is the entry point into continuum care; a well-recognized necessary condition for ultimate prevention onward transmission. In China, testing rates among men who have sex with (MSM) are low compared to other high risk subgroups, yet experiences MSM in China not well understood. To address this gap and prepare intervention development promote rapid linkage treatment, six focus groups (FGs) were conducted Beijing (40 HIV-positive participated one four FGs 20 HIV-negative or...
Cholera toxin B subunit (CTB) was investigated as a classical mucosal adjuvant that can increase vaccine immunogenicity. In this study, we found out the in vitro efficacy of cholera activating mice bone marrow-derived dendritic cells (BMDCs) through Toll-like receptor signaling pathways. RNA and transcriptional level profiling arrays revealed CTB guides high levels Th1 Th2 type cytokines, inflammatory chemokines. Based on robustness these results, examined induction HIV Env-specific immunity...
Abstract To investigate the origins of HIV transmission and phylogenetic dynamics among men who have sex with (MSM), a total 1205 newly diagnosed HIV-infected 16–25 year-olds were recruited in 13 provinces across China between 2009 2014. Based on analyses partial pol sequences, HIV-1 subtypes including CRF01_AE (45.3%), CRF07_BC (37.8%), subtype B (6.1%) B’ (3.7%), as well some other recombinants (7.1%) identified. In addition to two distinct clusters [cluster 4 (33.7%, 406/1205) cluster 5...