A5032080960- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Microbial infections and disease research
- Healthcare Systems and Reforms
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Disease Management Strategies
- Cytomegalovirus and herpesvirus research
- interferon and immune responses
- Animal Disease Management and Epidemiology
- Ectopic Pregnancy Diagnosis and Management
- Vestibular and auditory disorders
- Immune Cell Function and Interaction
- Bacillus and Francisella bacterial research
- Healthcare Policy and Management
- Chronic Lymphocytic Leukemia Research
- Whipple's Disease and Interleukins
- Rabies epidemiology and control
- Toxoplasma gondii Research Studies
- Coccidia and coccidiosis research
- Animal Virus Infections Studies
Guangdong Provincial People's Hospital
2018-2024
Southern Medical University
2019-2024
Clover Biopharmaceuticals (China)
2021-2022
Chinese Center For Disease Control and Prevention
2012-2017
Creative Commons
2015
Guangxi Center for Disease Prevention and Control
2015
Institute of Microbiology
2010-2013
Center for Disease Control
2012
Jishou University
2010
Institute of Microbiology
2010
Coxsackieviruses A10 (CV-A10) and A6 (CV-A6) have been associated with increasingly occurred sporadic hand-foot-mouth disease (HFMD) cases outbreak events globally. However, our understanding of epidemiological genetic characteristics these new agents remains far from complete. This study was to explore the circulation CV-A10 CV-A6 in HFMD their China. A hospital based surveillance performed three heavily inflicted regions March 2009 August 2011. Feces samples were collected children...
Abstract To investigate the origins of HIV transmission and phylogenetic dynamics among men who have sex with (MSM), a total 1205 newly diagnosed HIV-infected 16–25 year-olds were recruited in 13 provinces across China between 2009 2014. Based on analyses partial pol sequences, HIV-1 subtypes including CRF01_AE (45.3%), CRF07_BC (37.8%), subtype B (6.1%) B’ (3.7%), as well some other recombinants (7.1%) identified. In addition to two distinct clusters [cluster 4 (33.7%, 406/1205) cluster 5...
Background. In early September 2009, an outbreak of influenza occurred at a college campus in Beijing, China, which both pandemic H1N1 and seasonal H3N2 viruses were detected. Methods. Outbreak investigation was performed the campus. Epidemiologic, clinical data collected by interviewing patients retrieving medical records. Individual contact tracing for detailed information. Viruses identified reverse-transcription polymerase chain reaction assays followed sequence analysis. The...
Objective To explore HIV virological failure and drug resistance among injecting users (IDUs) receiving first-line antiretroviral treatment (ART) in China. Design A series of cross-sectional surveys from 2003 to 2012 the Chinese National Drug Resistance (HIVDR) Surveillance Monitoring Network. Setting Participants Data were analysed by Network 2012. Demographic, ART laboratory data (CD4+ cell count, viral load resistance) included. Factors associated with identified logistic regression...
Abstract Background China's National Free Antiretroviral Treatment Program (NFATP) has significantly scaled up and standardized treatment since 2008. Meanwhile, no study worldwide examined on a large scale the effects of rapid ART programme scale-up outcomes in resource-limited settings. Methods We used national HIV drug resistance (HIVDR) surveillance database to determine virological failure, acquired poor adherence rates after 12–15 months first-line ART. A total 2252 patients were...
Health care maldistribution is a long-term problem in China. Telemedicine an efficient way to deliver medical resources remote areas; however, there are few studies on the effectiveness and challenges providing health from rural urban areas China.The objective was describe of telemedicine for Guangzhou Guangdong Province.We designed surveys conducted them immediately after consultation 2-4 weeks later. Data were collected June 2015 May 2016 including patients' demographic features, patient...
Abstract Beginning in late 2020, the emergence and spread of multiple variant SARS-CoV-2 strains harboring mutations which may enable immune escape necessitates rapid evaluation second generation COVID-19 vaccines, with goal inducing optimized responses that are broadly protective. Here we demonstrate a mouse immunogenicity study two doses modified B.1.351 spike (S)-Trimer vaccine (B.1.351 S-Trimer) candidate can induce strong humoral neutralize both original strain (Wuhan-Hu-1) Variants...
Objective To determine the prevalence of virological failure and HIV drug resistance among Chinese patients one year after initiating lamivudine-based first-line antiretroviral treatment. Methods A prospective cohort study with follow-up at 12 months was conducted in four urban sentinel sites China. Antiretroviral naive ≥18 years old were recruited. Blood samples collected for testing CD4 cell count, viral load, (for HIV-1 RNA ≥1000 copies/ml) genotyping resistance. Results total 513...
Abstract Dehong prefecture, Yunnan province on China’s southwestern border was the gateway of country’s AIDS epidemic. Studies HIV-1 molecular epidemiology will provide key information virus transmission dynamics and help to inform HIV prevention strategies. infected youths (age 16–25 years) diagnosed in continuous 3 months 2009 2012 were enrolled. By means phylogenetic statistical analyses, It showed that two thirds (133/205) Dehong, which 74.1% sexually, by uncharacterized recombinant...
To explore factors associated with HIV virological failure (VF) and drug resistance (HIVDR) among HIV-positive Chinese individuals 4 years after initiating first-line lamivudine-based antiretroviral treatment (ART) in 2008 at five sentinel sites.First-line ART initiators who were previously naïve selected using consecutive ID numbers from the National Surveillance Database into a prospective cohort study. Questionnaires blood samples collected 2011 2012 to assess outcomes of interest: VF...
Abstract Antiretroviral therapy has significantly expanded and an increased proportion of patients have switched to second-line regimens in China. We describe the outcomes among having received long-term first-line ART. A prospective follow-up study was conducted rural areas compared virological, immunological genotypic drug resistance (DR) profiles before after regimen switches. total 303 were enrolled, 283 (93.4%) retained at 12 months. Of 90 participants with HIV-RNA ≥ 1000 copies/ml...
It is known that transmitted drug resistance (TDR) will most likely emerge in regions where antiretroviral therapy (ART) has been widely available for years. However, after a decade of rapid scale-up ART China, there are few data regarding TDR among HIV-infected patients prior to initiating first-line China. A prospective, observational cohort study was performed at sentinel sites five provinces or municipalities. Study participants were recruited the county- city-level centers disease...
The aim of this study was to analyze the distribution clusters and drug resistance CRF01_AE among newly diagnosed, treatment-naïve HIV-infected teenagers young adults in 3 major HIV-affected geographic regions Guangxi Province, including cities Hezhou, Liuzhou, Nanning. Samples were sequentially collected from diagnosed 16- 25-year olds these 2009 2013. viral genome extracted, partial pol gene amplified sequenced. Phylogenetic analyses used determine HIV-1 subtypes clusters. Transmitted...
Background. We followed a cohort of 773 individuals who received monovalent vaccine against 2009 pandemic influenza A (H1N1). Approximately 6 weeks after vaccination, 12 persons developed the disease. Methods. Three groups subjects were studied (12 patients had or not previous and 1 group 49 control previously been immunized with same vaccine). For all patients, clinical features characterized causative viruses sequenced for possible mutations. Nasopharyngeal swabs, serum specimens,...
<h2>Summary</h2><h3>Objective</h3> This study explored electrophysiological changes in the laryngeal motor neuropathway and determined whether lesions cortex (LMC) its descending tract contribute to voice deterioration peripheral nerve palsy patients with nasopharyngeal carcinoma (NPC) postradiotherapy (RT). <h3>Study designs</h3> Prospective cohort study. <h3>Methods</h3> Twenty-two NPC at 2 4years post-RT (8 female 14 male), 22 8 10years healthy individuals (9 13 male) were selected test...
To study the prevalence of primary HIV-1 drug resistance in newly reported HIV infected individuals receiving no antiviral treatment Henan.Network direct reporting information infection cases six cities Henan during January to June, 2013 and 2014 were collected, blood samples collected from conduct genotypic test sequence analysis.Primary was detected 45 624 cases, 7.21%, which classified as moderate. Univariate analysis revealed that higher females(χ(2)=11.463, P = 0.001), age group <20...
We evaluated an In-house assay for HIV-1 drug resistance genotyping by using DBS samples in China.The amplification sensitivity was assessed 79 specimens with plasma viral load ranging from 1,000 to 6,000 copies/ml. Precision 5 replicates tested one test run. Reproducibility other genotyped runs. Nucleotide sequence identity and the degree of concordance detecting mutations were within between In addition, nucleotide compared 64 matched specimens.The rate 1,000-6,000 copies/ml 96.2% (76/79)....