A5102836681- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacteriophages and microbial interactions
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- HIV, Drug Use, Sexual Risk
- Blood groups and transfusion
- Tuberculosis Research and Epidemiology
- HIV-related health complications and treatments
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Tryptophan and brain disorders
- Glycosylation and Glycoproteins Research
- Genomics and Phylogenetic Studies
- Immunodeficiency and Autoimmune Disorders
- Sex work and related issues
- Immunotherapy and Immune Responses
- Biochemical and Molecular Research
- Evolution and Genetic Dynamics
- Inflammasome and immune disorders
- Asthma and respiratory diseases
Changchun University of Chinese Medicine
2025
National Center for AIDS/STD Control and Prevention,China CDC
2007-2024
Jiangsu University
2024
Affiliated Hospital of Jiangsu University
2024
Houston Methodist
2024
Weill Cornell Medicine
2024
Methodist Hospital
2024
Cornell University
2024
Jining Traditional Chinese Medicine Hospital
2024
State Key Laboratory of Infectious Disease Prevention and Control
2021-2023
A molecular epidemiology study was conducted among more than 100 human immunodeficiency virus type 1 (HIV-1) subtype C seropositive intravenous drug users (IDUs) from China. Genotyping based on the envelope C2V3 coding region revealed highest homology of most prevalent strains circulating throughout China to sequences Indian origin. Based these results, a virtually full-length genome representing class clade directly amplified peripheral blood mononuclear cells selected HIV-infected IDU and...
The HIV-1 epidemic in Shanghai is rapidly increasing. To better understand the genetic diversity and mutations associated with resistance to protease inhibitors (PIs) reverse transcriptase (RTIs), 95 antiretroviral (ARV)-treated treatment-naive HIV-1-seropositive individuals living were investigated. pol gene 70 of plasma samples was successfully amplified analyzed. result showed that CRF01_AE predominated 42.9%, followed by subtype B (10%), B′ (12.9%), CRF07_BC (11.4%), CRF08_BC CRF02_AG...
The prevalence of CRF07_BC is 39.7% and has become the most infectious HIV strain in China. To study transmission diffusion trajectory China to prevent further expansion its transmission. A total 16,635 sequences pol gene were collected from 1997-2020. We characterized subtypes according a phylogenetic tree analysis. 0.50% molecular network was constructed analyze relationship among different provinces for two epidemic clusters. Spatial temporal propagation characteristics analyzed...
HIV drug resistance compromises the ability of anti-retroviral therapy (ART) to suppress viral replication, resulting in treatment failure. This study investigates prevalence pre-treatment (PDR) newly diagnosed individuals a prosperous city (Wenzhou) Southeastern China. A cross-sectional investigation was carried out among 473 ART-naive HIV-1-infected between January and December 2022. The protease–reverse transcriptase (PR-RT) region integrase (IN) HIV-1 were amplified by two separately...
With the expansion of human immunodeficiency virus (HIV) antiretroviral therapy (ART), HIV drug resistance is becoming more and serious. This study describes changing prevalence HIV-1 subtypes transmitted (TDR) among newly diagnosed individuals in China, 2015 2018.A total 8,980 2018 from 31 provincial-level administrative divisions (PLADs) were enrolled this study. Viral RNAs amplified sequenced using an in-house polymerase chain reaction (PCR) protocol. The Stanford Drug Resistance Database...
Background Unregulated commercial blood/plasma collection among farmers occurred between 1992 and 1995 in central China caused the second major epidemic of human immunodeficiency virus type 1 (HIV-1) infection China. It is important to characterize HIV-1-infected former blood donors study characteristics associated with disease progression for future clinical intervention vaccine development. Methods A cross-sectional was performed on (FBDs) age-matched HIV-seronegative local residents....
Background: Attrition due to loss follow-up or termination of antiretroviral therapy (ART) among HIV-infected patients in care may increase the risk emergence and transmission drug resistance (TDR), diminish benefit treatment, morbidity mortality. Understanding impact attrition on epidemic is essential provide interventions for improving retention care. Methods: We developed a comprehensive HIV dynamics model by considering CD4 + cell count dependent diagnosis, involving TDR acquired...
Though HIV-1 CRF07_BC rapidly spread in China, there have been few reports about this subtype since its first genetic characterization nearly 10 years ago. It was urgent and necessary to know the current gene variation of circulating strains. Xinjiang main region for epidemic also an ideal research on viral evolution. The strains Ulumuqi Yili were isolated, cloned, sequenced study. Analyses phylogenetic, potential CTL epitopes N-glycosites preformed simultaneously. New isolates showed higher...
To study the characteristics of HIV pretreatment drug resistance (PDR) and acquired (ADR) in Hefei, a cross-sectional survey was used to collect 816 samples from newly reported infections 2017 2020 127 with virological failure 2018 2019 Hefei. levels mutations were interpreted using Stanford Drug Resistance Database. Molecular networks constructed by HIV-TRACE. Among prevalence PDR 6.4% (52/816). The mainly V179E/D/T (12.4%), K103N (1.3%), V106I/M (1.3%). In addition, it found that CRF55_01B...
Background Long-term non-progressors (LTNPs) with HIV infection can naturally control viral replication for up to a decade without antiretroviral therapy (ART), but the underlying mechanisms of this phenomenon remain elusive. Methods To investigate relevant immune and inflammatory factors associated natural mechanism, we collected plasma samples from 16 LTNPs, 14 untreated progressors (VPs), 17 successfully ART-treated patients (TPs), healthy controls (HCs). The OLINK response panel...
CRF01_AE, which has led a new epidemic in many provinces China and displayed complex characteristics, now evolved into multiple clusters China. Some often circulate specific regions or among risk populations To better determine the characteristics of CRF01_AE circulating Anhui Province, we analyzed based on gag pol sequences. Our results showed that Province was clearly divided three clusters. Cluster 1 covered 90% sequences all CRF01_AE. Among 1, from men who have sex with (MSM)...
Hefei, Anhui province, is one of the cities in Yangtze River Delta, where many people migrate to Jiangsu, Zhejiang and Shanghai. High migration also contributes HIV epidemic. This study explored prevalence Hefei provide a reference for other provinces assist prevention control China. A total 816 newly reported with from 2017 2020 were recruited as subjects. subtypes identified by phylogenetic tree. The most prevalent CRF07_BC (41.4%), CRF01_AE (38.1%) CRF55_01B (6.3%). Molecular networks...
HIV-1 CRF07_BC constitutes a large fraction of strains circulating in China and is responsible for the rapidly expanding epidemic across country. Little known about biological characteristics viruses, particularly propensity by which this recombinant form HIV replicates within an infected individual. In study, near-full-length genome virus from injecting drug user (IDU) Xingjiang region was cloned rescued functional 5′ LTR (long terminal repeat region) 3′ pNL4-3 to produce chimeric...
Clusters of genetically similar infections suggest rapid transmission and may indicate priorities for public health action or reveal underlying epidemiological processes. However, clusters often require user-defined thresholds are sensitive to non-epidemiological factors, such as non-random sampling. Consequently the ideal threshold applications varies substantially across settings. Here, we show a method which selects optimal phylogenetic (subset tree) clustering based on population. We...