miRNAs are small, non-coding RNAs that play important roles in various biological processes. The aims of our study were to investigate whether cell-free can be measured urine samples and might an accurate biomarker bladder cancer. Datasets GSE20418 GSE19717 used for analysis, two miRNAs, miR-145 miR-200a, selected study. A total 207 patients with primary transitional cell carcinoma the urinary 144 healthy normal controls enrolled. Using quantitative PCR, levels miR-200a compared...

Low molecular weight fucoidan (LMF) has been reported to possess anti-inflammatory and antioxidant activities. Thus, we examined the effects of LMF extracted from Undaria pinnatifida on dermal wounds. Five round wounds were created dorsal back rats, they then treated topically with distilled water (DW), Madecasol Care™ (MC) or at 200, 100 50 mg/mL, twice a day for week. There dose-dependent increases in wound contraction groups receiving but not MC group, compared DW. Histopathological...

Extracorporeal Shock Wave Lithotripsy (ESWL) has shown successful outcomes for ureteral stones. We investigated predictive factors failure of ESWL treating stones.A total 153 patients who underwent between July 2006 and 2009 stones diagnosed by non-enhanced spiral computed tomography were divided into two groups: (group A, stone size ≤10 mm; group B, >10 mm). The was defined as remnant >4 mm. assessed age, sex, body mass index, size, laterality, location, skin-to-stone distance (SSD),...

Ultraviolet (UV) B exposure induces DNA damage and production of reactive oxygen species (ROS), which causes skin photoaging through signaling pathways inflammation modulation extracellular matrix remodeling proteins, collagens, metalloproteinase (MMP). As low molecular-weight fucoidan (LMF) has potential antioxidant anti-inflammatory properties, we examined the protective effects LMF against UVB-induced photoaging. A UVB-irradiated mouse model was topically treated with myricetin or at 2.0,...

Purpose:We investigated the long-term survival and patient satisfaction with an inflatable penile prosthesis as a treatment for refractory erectile dysfunction (ED).Materials Methods: Between July 1997 September 2014, total of 74 patients underwent implantation prosthesis.The present mechanical status was ascertained by telephone interview review medical records, related clinical factors were analyzed using Cox proportional hazard regression model.To investigate current devices, novel...

Purpose:We examined the correlation between body mass index (BMI) as a marker of obesity and prostate-specific antigen (PSA), prostate volume (PV), International Prostate Symptom Score (IPSS) in patients with benign prostatic hyperplasia (BPH).Materials Methods: From January 2008 to December 2008, we 258 diagnosed BPH.Patients taking 5α-reductase inhibitors or those cancer were excluded from this study.BPH was defined PV≥25 ml IPSS≥8.BMI (kg/m 2 ) categorized into 4 groups follows: BMI＜18.5...

We conducted this study to investigate the synergistic effect of human urine-derived stem cells (USCs) and surface modified composite scaffold for bladder reconstruction in a rat model.The (Polycaprolactone/Pluronic F127/3 wt% submucosa matrix) was fabricated using an immersion precipitation method, heparin immobilized on via covalent conjugation.Basic fibroblast growth factor (bFGF) loaded onto heparin-immobilized by simple dipping method.In maximal capacity compliance analysis at 8 weeks...

The purpose of this study is to examine the factors that influence school life satisfaction based on personal variables, self-esteem, interpersonal relationships, and perception educational environment at a medical in Korea. data were collected from 228 students who agreed participate school. Dundee Ready Medical Environment Measure (DREEM) self-esteem scale by Rosenberg used. Questions measuring relationships (with professors, with senior/junior students, friends) asked using 5 point Likert...

Purpose We evaluated 5 different rat models using agents in order to establish a standard animal model for interstitial cystitis (IC) terms of the functional and pathologic characteristics bladder. Methods Five IC were generated 8-week-old female Sprague-Dawley rats via transurethral instillation 0.1M hydrogen chloride (HCl) or 3% acetic acid (AA), intraperitoneal injection cyclophosphamide (CYP) lipopolysaccharide (LPS), subcutaneous uroplakin II (UPK2). After generating models, conscious...

Purpose: Though urodynamic study (UDS) is the current established standard to distinguish between detrusor underactivity (DU) and bladder outlet obstruction (BOO), concerns of patient discomfort potential complications catheterization deters its use.We inspected clinical variables discriminate DU BOO in uroflowmetry, which can be more easily performed practice.Materials Methods: Total 240 men who both underwent UDS uroflowmetry were reviewed.The patients divided into 2 groups by a single...

To evaluate the long-term results and predictive risk factors for efficacy after tension-free vaginal tape (TVT) procedure treating female stress urinary incontinence (SUI).Inall, 306 women (mean age 50.7 years, sd 8.7) who had a TVT SUI were selected followed >or=7 years 92.3 months, range 84-110) surgery. We analysed results, variables of cure rates, patient satisfaction.The overall 7-year rate was 84.6%, with satisfaction 69.3%. The rates lower in patients high-grade (50% grade III, 82.8%...

We evaluated the effectiveness of microsurgical ligation for painful varicocele and predictive factors pain resolution.Between January 2006 March 2009, a total 114 patients (mean age, 30.2 ± 8.9 years), who underwent inguinal varicocelectomy varicocele, were included followed up 1 year after surgery. The quantity preoperative postoperative was assessed by means 11-point numeric rating scale (NRS). retrospectively analyzed outcome surgical resolution using patient height, weight, body mass...

Acellular scaffolds, possessing an intact three-dimensional extracellular matrix (ECM) architecture and biochemical components, are promising for regeneration of complex organs, such as the kidney. We have successfully developed a porcine renal acellular scaffold analyzed its physical/biochemical characteristics, biocompatibility, kidney reconstructive potential. Segmented cortexes were treated with either 1% (v/v) Triton X-100 (Triton) or sodium dodecyl sulfate (SDS). Scanning electron...

Matrix Grafts for the Management of Long-Segment Urethral Stricture in a Rabbit ModelWe conducted this study to evaluate combined effect acellular bladder submucosa matrix (BSM) and autologous urethral tissue treatment long segment stricture rabbit model.To prepare BSM, porcine was processed, decellularized, configured into sheet-like shape, sterilized.Twenty rabbits were randomized normal control, stricture, urethroplasty using BSM only or BSM/ (n = 5 per group).Retrograde urethrography...

To investigate the role of initial procalcitonin (PCT) level as an early predictor septic shock for patient with sepsis induced by acute pyelonephritis (APN) secondary to ureteral calculi.The data from 49 consecutive patients who met criteria due APN following stone were collected and divided into two groups: (n=15) or without (n=34) shock. The clinical variables including PCT this outcome retrospectively compared univariate analysis, followed multivariable logistic regression model.All...

Abstract Background Bladder cancer (BC) is one of the most common malignancies urinary tract. The role transient receptor potential melastatin 7 (TRPM7) in BC remains unclear. aim this study was to investigate function and signal transduction pathway TRPM7 BC. Methods T24 UMUC3 cells were used evaluate molecular mechanism by immunoblot analysis. Small interfering RNA knockdown TRPM7, effect silencing studied wound healing, migration, invasion assays cells. Xenograft model obtained analyze...

Bipolar energy has recently been used for transurethral resection of bladder tumor (TURBT). Although this modality is thought to be safe, there are some controversies concerning the pathologic accuracy biopsy specimens. We compared clinical efficacy, safety, and characteristics deep specimens between bipolar monopolar devices.From January 2002 June 2007, a total 115 patients underwent TURBT with use (bipolar group, n=64) or (monopolar n=51) devices. retrospectively analyzed size, number,...

Purpose: Partial nephrectomy (PN) for patients with T1a renal cell carcinoma (RCC) has increasingly become accepted, although its role T1b RCC remains controversial.We retrospectively evaluated and then compared the oncologic functional outcomes of pT1b who were treated PN or radical (RN).Materials Methods: A total 70 diagnosed pT1bN0M0 between January 1995 December 2004 included.The 5-year overall survival (OS), recurrence-free (RFS), cancer-specific (CSS) groups.Preoperative postoperative...

Objectives To evaluate the effect on sexual function of patients and their spouses after transobturator tape ( TOT ) procedure, prospectively. Midurethral sling procedure has been widely performed for treatment urinary incontinence; however, little reported regarding surgery. Methods Between S eptember 2012 J une 2013, 65 undergoing partners were enrolled. An investigation was conducted using validated, self‐administered questionnaires, F emale exual unction I ndex FSFI satisfaction domain M...