A5001212085- Pharmacological Effects of Natural Compounds
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Glycation End Products research
- Natural product bioactivities and synthesis
- Immune Response and Inflammation
- Ginseng Biological Effects and Applications
- Drug-Induced Hepatotoxicity and Protection
- Genomics, phytochemicals, and oxidative stress
- Polysaccharides and Plant Cell Walls
- Phytochemicals and Antioxidant Activities
- Neuropeptides and Animal Physiology
- Blood Coagulation and Thrombosis Mechanisms
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- Inflammatory mediators and NSAID effects
- Liver Disease Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Skin Protection and Aging
- Pancreatic function and diabetes
- Ginger and Zingiberaceae research
- NF-κB Signaling Pathways
- Polysaccharides Composition and Applications
- Natural Antidiabetic Agents Studies
- Bone Metabolism and Diseases
Daegu Haany University
2016-2025
Convergence
2020
Government of the Republic of Korea
2014-2020
Dunsan Korean Medicine Hospital
2020
Kyungpook National University
1998-2019
Yeungnam University
2011-2017
Daegu University
2014-2017
National University of Malaysia
2014
Catholic University of Daegu
2013
Daekyeung University
2013
Abstract Transcription factor NRF2 is an important modifier of cellular responses to oxidative stress. Although its cytoprotective effects are firmly established, recent evidence suggesting roles in cancer pathobiology has yet be mechanistically developed. In the current study, we investigated role colon tumor angiogenesis. Stable RNAi-mediated knockdown human cells suppressed growth mouse xenograft settings with a concomitant reduction blood vessel formation and VEGF expression. Similar...
Therapeutic antibodies that block vascular endothelial growth factor (VEGF) show clinical benefits in treating nonsmall cell lung cancers (NSCLCs) by inhibiting tumor angiogenesis. Nonetheless, the therapeutic effects of systemically administered anti-VEGF are often hindered NSCLCs because their limited distribution lungs and adverse on normal tissues. These challenges can be overcome delivering mRNA form to cells, a primary target VEGF-mediated pulmonary angiogenesis, suppress NSCLCs. In...
Curcumin, a polyphenol responsible for the yellow color of curry spice turmeric, possesses antiinflammatory, antiproliferative and antiangiogenic activities. However, anticoagulant activities curcumin have not been studied. Here, properties its derivative (bisdemethoxycurcumin, BDMC) were determined by monitoring activated partial thromboplastin time (aPTT), prothrombin (PT) as well cell-based thrombin factor X (FXa) generation Data showed that BDMC prolonged aPTT PT significantly inhibited...
Cluster of differentiation 44 (CD44) is the most common cancer stem cell (CSC) marker and high CD44 expression has been associated with anticancer drug resistance, tumor recurrence, metastasis. In this study, we aimed to investigate molecular mechanism by which nuclear factor erythroid 2-like 2 (NFE2L2; NRF2), a key regulator antioxidant genes, are linked CSC resistance using CD44high breast CSC-like cells. NRF2 was higher in populations isolated from doxorubicin-resistant MCF7 (ADR), as...
Endocan is a proteoglycan secreted by endothelial cells under the control of inflammatory cytokines. The aim this study was to evaluate effects endocan on proinflammatory responses and septic mice underlying mechanisms. Human umbilical vein (HUVECs) or were exposed lipopolysaccharide (LPS) with without neutralizing antibody. Mice subjected cecal ligation puncture (CLP) surgery highly released LPS it enhanced responses. In CLP‐induced sepsis model, also released, but release prevented...
The purpose of this study is to investigate the clinical effects platelet-rich plasma (PRP) and adipose-derived mesenchymal stem cell (MSC) as fundamental treatment osteoarthritis (OA).Twenty four Beagle dogs were used cranial cruciate ligament transection models. divided into groups (n = 6) according intra-articular injection materials: control group with phosphate-buffered saline (PBS), PRP PRP, MSC MSCs emerged in PBS, co-treatment (MP) PRP.Lameness score, focal compression strength,...
Folate-targeting self-assembled nanoparticles (NPs) using biocompatible and biodegradable natural polymers chitosan (Cs) chondroitin sulfate (Chs) were developed to address the major challenge in cancer treatment, selective delivery of target site. In this study, we successfully incorporated a hydrophobic drug, bortezomib (Bor), into folic acid (FA)-conjugated Cs/Chs NPs (Bor/Cs/Chs-FA) for colorectal therapy. The particle size polydispersity index Bor/Cs/Chs-FA ∼196.5 ± 1.2 nm ∼0.21 0.5,...
In this study, a transferrin (Tf)-conjugated polymeric nanoparticle was developed for the targeted delivery of chemotherapeutic agent doxorubicin (Dox) in order to overcome multi-drug resistance cancer treatment. Our objective improve Dox producing significant antitumor efficacy Dox-resistant (R) breast cell lines with minimum toxicity healthy cells. The results our experiments revealed that successfully loaded inside composed poloxamer 407 (F127) and 123 (P123) (Dox/F127&P123-Tf), which...
Multimodal therapeutic agents based on novel nanomaterials for multidrug resistance have attracted increasing attention in cancer therapy. In this study, we describe the construction of a programmed mesoporous silica-capped gold nanorod covered with nano-selenium overcoat (Se@Au@mSiO2) nanoparticles as multifunctional nanoplatform to incorporate materials specific chemotherapeutic, chemoprevention, and photoablation/hyperthermia functions that collectively contribute enhance anticancer...
The efficacy of combined near-infrared (NIR) and immune therapies for inhibiting tumor growth recurrence has gained increasing research attention. Regulatory T cells in the microenvironment constitute a major obstacle achieving robust CD8+ cell antitumor immunotherapy. In present study, we designed photoimmunotherapy-based strategy involving combination photothermal photodynamic therapies, followed by Treg suppression, eliciting an response with IR-780- imatinib-loaded layer-by-layer hybrid...
Vascular inflammatory process has been suggested to play a key role in initiation and progression of atherosclerosis, major complication diabetes mellitus. Thus, this study, we attempted determine whether three structurally related polyphenols found the Chinese herb Huang Qui, namely baicalin, baicalein, wogonin, can suppress vascular processes induced by high glucose (HG) human umbilical vein endothelial cells (HUVECs) mice. Data showed that HG markedly increased permeability, monocyte...
Intravenously administered for the treatment of rectum cancer, irinotecan produces severe side effects due to very high plasma concentrations. A novel irinotecan-encapsulated double reverse thermosensitive nanocarrier system (DRTN) rectal administration was developed as an alternative. The DRTN fabricated by dispersing solid lipid nanoparticles (SLN) in poloxamer solution. Its gel properties, pharmacokinetics, morphology, anticancer activity and immunohistopathology were assessed after its...
Low molecular weight fucoidan (LMF) has been reported to possess anti-inflammatory and antioxidant activities. Thus, we examined the effects of LMF extracted from Undaria pinnatifida on dermal wounds. Five round wounds were created dorsal back rats, they then treated topically with distilled water (DW), Madecasol Care™ (MC) or at 200, 100 50 mg/mL, twice a day for week. There dose-dependent increases in wound contraction groups receiving but not MC group, compared DW. Histopathological...