A5101853050- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Advancements in Transdermal Drug Delivery
- Photodynamic Therapy Research Studies
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Surfactants and Colloidal Systems
- Gold and Silver Nanoparticles Synthesis and Applications
- Liquid Crystal Research Advancements
- Cardiovascular Effects of Exercise
- Pharmacological Effects of Natural Compounds
- Immunotherapy and Immune Responses
- Antibiotic Use and Resistance
- Drug Solubulity and Delivery Systems
- Disaster Response and Management
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Blood Pressure and Hypertension Studies
- Acute Lymphoblastic Leukemia research
- Analytical Chemistry and Chromatography
- Hidradenitis Suppurativa and Treatments
- Economic and Financial Impacts of Cancer
- Coronary Artery Anomalies
Western University
2024
Bir Hospital
2017-2023
Nepalese Army Institute of Health Services
2017-2023
Pokhara University
2012-2022
Patan Academy of Health Sciences
2017-2021
Patan Hospital
2017-2020
University of Oslo
2020
Yeungnam University
2012-2019
Kathmandu Medical College Teaching Hospital
2019
Marymount University
2018
Folate-targeting self-assembled nanoparticles (NPs) using biocompatible and biodegradable natural polymers chitosan (Cs) chondroitin sulfate (Chs) were developed to address the major challenge in cancer treatment, selective delivery of target site. In this study, we successfully incorporated a hydrophobic drug, bortezomib (Bor), into folic acid (FA)-conjugated Cs/Chs NPs (Bor/Cs/Chs-FA) for colorectal therapy. The particle size polydispersity index Bor/Cs/Chs-FA ∼196.5 ± 1.2 nm ∼0.21 0.5,...
In this study, a transferrin (Tf)-conjugated polymeric nanoparticle was developed for the targeted delivery of chemotherapeutic agent doxorubicin (Dox) in order to overcome multi-drug resistance cancer treatment. Our objective improve Dox producing significant antitumor efficacy Dox-resistant (R) breast cell lines with minimum toxicity healthy cells. The results our experiments revealed that successfully loaded inside composed poloxamer 407 (F127) and 123 (P123) (Dox/F127&P123-Tf), which...
The efficacy of combined near-infrared (NIR) and immune therapies for inhibiting tumor growth recurrence has gained increasing research attention. Regulatory T cells in the microenvironment constitute a major obstacle achieving robust CD8+ cell antitumor immunotherapy. In present study, we designed photoimmunotherapy-based strategy involving combination photothermal photodynamic therapies, followed by Treg suppression, eliciting an response with IR-780- imatinib-loaded layer-by-layer hybrid...
Intravenously administered for the treatment of rectum cancer, irinotecan produces severe side effects due to very high plasma concentrations. A novel irinotecan-encapsulated double reverse thermosensitive nanocarrier system (DRTN) rectal administration was developed as an alternative. The DRTN fabricated by dispersing solid lipid nanoparticles (SLN) in poloxamer solution. Its gel properties, pharmacokinetics, morphology, anticancer activity and immunohistopathology were assessed after its...
Because of their extraordinary physical properties and biocompatibility, black phosphorus (BP) nanosheets (NSs) have been intensively employed in chemo-phototherapies, such as plasmonic inorganic nanoparticles or graphene NSs, over the past few years. However, most biomedical studies using BP NSs are only concerned with optical property to repeatedly demonstrate chemo-phototherapeutic efficacies, although different from corrugated crystal structure, hydrophilicity, biodegradability....
Metastasis of cancers accounts for almost all cancer-related deaths. In this study, we report a PEGylated nanostructured platform coadministration doxorubicin (DOX) and imatinib (IMT) intended to effectively inhibit metastatic tumors. The DOX IMT coloaded system (DOX/IMT-N) is characterized by an excellent encapsulation potential both drugs shows sequential sustained drug release in vitro. DOX/IMT-N significantly inhibited the vitro proliferation MDA-MB-231 SK-MEL-28 cells. inhibitory effect...
Cancer remains a leading cause of death. A combination anticancer agents can effectively kill cancer through multiple pathways; however, improvements to their delivery are needed. Hence, docetaxel and cisplatin-loaded liquid crystalline nanoparticles with folic acid were prepared for effective targeted therapy. Notably, hydroxypropyl-β-cyclodextrin/cisplatin complexes in 0.9% NaCl solution used the prevention possible aquation cisplatin, which would otherwise lead severe adverse effects. The...
Several therapeutic nanosystems have been engineered to remedy the shortcomings of cancer monotherapies, including immunotherapy (stimulating host immune system eradicate cancer), improve efficacy with minimizing off-target effects and tumor-induced immunosuppression.Light-activated components in confer additional phototherapeutic as combinatorial modalities; however, systemic thermal toxicities unfavorable accumulation excretion nanoystem now hamper their practical applications.Thus, there...