A5085961215- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Mycobacterium research and diagnosis
- RNA regulation and disease
- Nanoparticles: synthesis and applications
- Infectious Diseases and Mycology
- Dendrimers and Hyperbranched Polymers
- Acute Myocardial Infarction Research
- Congenital Heart Disease Studies
- Laser-Ablation Synthesis of Nanoparticles
- interferon and immune responses
- Natural Compounds in Disease Treatment
- Heart Failure Treatment and Management
- Advanced Nanomaterials in Catalysis
- Aquaculture disease management and microbiota
- Milk Quality and Mastitis in Dairy Cows
- Viral Infections and Immunology Research
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Innovations in Concrete and Construction Materials
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
Oregon State University
2023-2024
Häme University of Applied Sciences
2020-2023
University of Prince Edward Island
2023
Centria University of Applied Sciences
2023
Yeungnam University
2017-2022
Massey University
2017-2021
Nepal Development Research Institute
2020-2021
Nepal Medical College Teaching Hospital
2021
Government of the Republic of Korea
2018-2020
Shahid Gangalal National Heart Centre
2017-2018
Lipid nanoparticle (LNP)-based mRNA delivery holds promise for the treatment of inherited retinal degenerations. Currently, LNP-mediated is restricted to pigment epithelium (RPE) and Müller glia. LNPs must overcome ocular barriers transfect neuronal cells critical visual phototransduction, photoreceptors (PRs). We used a combinatorial M13 bacteriophage-based heptameric peptide phage display library mining ligands that target PRs. identified most promising candidates resulting from in vivo...
Abstract Ocular delivery of lipid nanoparticle (LNPs) packaged mRNA can enable efficient gene and editing. We generated LNP variants through the inclusion positively charged-amine-modified polyethylene glycol (PEG)-lipids (LNPa), negatively charged-carboxyl-(LNPz) carboxy-ester (LNPx) modified PEG-lipids, neutral unmodified PEG-lipids (LNP). Subretinal injections LNPa containing Cre in mouse show tdTomato signal retinal pigmented epithelium (RPE) like conventional LNPs. Unexpectedly, LNPx...
Lipid nanoparticles (LNPs) largely rely on ionizable lipids to yield successful nucleic acid delivery via electrostatic disruption of the endosomal membrane. Here, we report identification and evaluation containing a thiophene moiety (Thio-lipids). The Thio-lipids can be readily synthesized Gewald reaction, allowing for modular lipid design with functional constituents at various positions ring. Through rational structure, prepared 47 identified some structural criteria required in efficient...
Folate-targeting self-assembled nanoparticles (NPs) using biocompatible and biodegradable natural polymers chitosan (Cs) chondroitin sulfate (Chs) were developed to address the major challenge in cancer treatment, selective delivery of target site. In this study, we successfully incorporated a hydrophobic drug, bortezomib (Bor), into folic acid (FA)-conjugated Cs/Chs NPs (Bor/Cs/Chs-FA) for colorectal therapy. The particle size polydispersity index Bor/Cs/Chs-FA ∼196.5 ± 1.2 nm ∼0.21 0.5,...
In this study, a transferrin (Tf)-conjugated polymeric nanoparticle was developed for the targeted delivery of chemotherapeutic agent doxorubicin (Dox) in order to overcome multi-drug resistance cancer treatment. Our objective improve Dox producing significant antitumor efficacy Dox-resistant (R) breast cell lines with minimum toxicity healthy cells. The results our experiments revealed that successfully loaded inside composed poloxamer 407 (F127) and 123 (P123) (Dox/F127&P123-Tf), which...
The consolidation of nanovectors with biological membranes has recently been a subject interest owing to the prolonged systemic circulation time and delayed clearance by reticuloendothelial system such systems. Among different biomembranes, macrophage membrane similar time, an additional chemotactic aptitude, targeting integrin proteins. In this study, we aimed establish laser-activated, disintegrable, deeply tumor-penetrative nanoplatform. We used highly tumor-ablative laser-responsive...
Cell-based delivery platforms have received great interest in recent years and been indicated as a promising strategy for cancer immunotherapy. Despite their wide applications the clinical preclinical stages, concomitant viability efficacy remain major issues. Herein, harnessing regulatory T (Treg) cells is developed an actively targeting drug-delivery system to transport drug-loaded liposomes desired tumor sites via conjugating on surface of Treg cells. Under guidance tumor-oriented...
In this study, we investigated the active targeted delivery of a hydrophobic drug, paclitaxel (PTX), via receptor-mediated endocytosis by folate receptors expressed on cancer cells using protein-based nanoparticle system. PTX was loaded zein nanoparticles and conjugated with (PTX/Zein-FA) to estimate its chemotherapeutic efficacy in receptor-expressing KB cells. PTX/Zein-FA were successfully developed, size ~180 nm narrow polydispersity index (~0.22). Accelerated release an acidic...
Cellular Fas-associated protein with death domain-like interleukin-1β-converting enzyme-inhibitory (c-FLIP), often strongly expressed in numerous cancers, plays a pivotal role thwarting apoptosis and inducing chemotherapy resistance cancer. An integrated approach combining suppression of c-FLIP levels could prove paramount the treatment cancers overexpression. In this study, we utilized polymeric layer-by-layer (LbL) assembly silica-supported mesoporous titania nanoparticles (MTNst) to...
Background Phytosterols significantly reduce the risk of cancer by directly inhibiting tumor growth, inducing apoptosis, and metastasis. Stigmasterol (STS), a phytosterol, exhibits anticancer effects against various cancers, including breast cancer. Chemotherapeutics, doxorubicin (DOX), might act synergistically with phytosterol proliferation metastasis Although such compounds can show potential activity, their combined effect suitable formulation has not investigated yet.Methods Hyaluronic...
Scheme of fabrication and action NUs after tumor internalization<italic>via</italic>folate receptors, redox-triggered S–S bond cleavage, laser-receptive behavior.