A5042180788- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Inhalation and Respiratory Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Microencapsulation and Drying Processes
- Virus-based gene therapy research
- Neonatal Respiratory Health Research
- T-cell and B-cell Immunology
- Pneumonia and Respiratory Infections
- Drug Solubulity and Delivery Systems
- SARS-CoV-2 and COVID-19 Research
- Nanoparticle-Based Drug Delivery
- Dendrimers and Hyperbranched Polymers
- Immune Cell Function and Interaction
- Protein purification and stability
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- DNA and Nucleic Acid Chemistry
- Dermatology and Skin Diseases
University of Copenhagen
2016-2025
Rigshospitalet
2025
Copenhagen University Hospital
2025
Institut de Recherche Vaccinale
2018
DK4
2015
Kobe Pharmaceutical University
2012
Karolinska University Hospital
2005
Schools of Visual Arts, The Royal Danish Academy of Fine Arts
2002
Design of inhalable mRNA therapeutics is promising, because local administration in the respiratory tract minimally invasive and induces a response. However, several challenges related to via inhalation barriers have so far prevented progress inhaled therapeutics. Here, we investigated factors importance for lipid nanoparticle (LNP)-mediated delivery tract. We hypothesized that: (i) PEG-lipid content important providing colloidal stability during aerosolization mucosal delivery, (ii)...
Summary Cationic liposomes are being used increasingly as efficient adjuvants for subunit vaccines but their precise mechanism of action is still unknown. Here, we investigated the adjuvant cationic based on synthetic amphiphile dimethyldioctadecylammonium (DDA). The did not have an effect maturation murine bone‐marrow‐derived dendritic cells (BM‐DCs) related to surface expression major histocompatibility complex (MHC) class II, CD40, CD80 and CD86. We found that ovalbumin (OVA) readily...
Inflammation is an essential component of many lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), or acute injury. Our purpose was to design efficient carriers for delivery small interfering RNA (siRNA) targeting tumor necrosis factor (TNF-α) in injury model. To achieve this goal, two different types phosphorus-based dendrimers with either pyrrolidinium morpholinium as terminal protonated amino groups were selected their better biocompatibility compared other...
Thermostable dry powder inhaler (DPI) formulations with high aerosol performance are attractive inhalable solid dosage forms for local treatment of inflammatory lung diseases. We recently demonstrated that lipidoid-polymer hybrid nanoparticles (LPNs) loaded small interfering RNA (siRNA) directed against tumor necrosis factor alpha (TNF-α) mediate efficient intracellular siRNA delivery and reduce inflammation in vivo. Here, we show mixtures the stabilizing excipients trehalose (Tre) dextran...