A5044288629- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Photodynamic Therapy Research Studies
- Hydrogels: synthesis, properties, applications
- Polymer Surface Interaction Studies
- Inhalation and Respiratory Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Advanced Polymer Synthesis and Characterization
- Dendrimers and Hyperbranched Polymers
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Gold and Silver Nanoparticles Synthesis and Applications
- Surfactants and Colloidal Systems
- Drug Transport and Resistance Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Cancer, Hypoxia, and Metabolism
- Supramolecular Chemistry and Complexes
- Microencapsulation and Drying Processes
- Extracellular vesicles in disease
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
Chung-Ang University
2016-2025
Columbia University Irving Medical Center
2024-2025
Korea University
2023-2024
New York Hospital Queens
2024
Columbia University
2010-2024
NewYork–Presbyterian Hospital
2024
Korea Institute of Energy Research
2023
Government of the Republic of Korea
2019
Korea National Tuberculosis Association
2018
Chonnam National University
2016
An optimized, pH-sensitive mixed-micelle system conjugated with folic acid is prepared in order to challenge multidrug resistance (MDR) cancers. The micelles are composed of poly(histidine (His)-co-phenylalanine (Phe))-b-poly(ethylene glycol) (PEG) and poly(L-lactic acid) (PLLA)-b-PEG-folate. Core-forming, hydrophobic blocks poly(His-co-Phe) varying composition synthesized. pH sensitivity the controlled by copolymer fine tuned early endosomal blending PLLA(3K)-b-PEG(2K)-folate presence a...
Sharper image: A newly developed polysaccharide/drug conjugate (see picture) responds to changes in pH value and was shown penetrate HeLa tumors mice as determined by fluorescence imaging. It has the potential be used photodynamic therapy, thereby targeting tumor while having no detrimental effects on surrounding tissue. Detailed facts of importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available...
Rabies virus-inspired silica-coated gold nanorods are fabricated by mimicking size, shape, surface glycoprotein property and in vivo behavior of the rabies virus. These not only resemble appearance actual virus but also travel into brain through neuronal pathway bypassing blood–brain barrier, moreover respond to near-infrared laser (808 nm) irradiation, emit heat, effectively suppress tumors. As a service our authors readers, this journal provides supporting information supplied authors....
Delivering the goods: A pH-sensitive nanogel consists of a hydrophobic copolymer core and two layers hydrophilic shell (see picture). The is loaded with model anticancer drug, doxorubicin (DOX). infects tumor cells in receptor-dependent manner, kills cells, migrates to neighboring like virus. BSA=bovine serum albumin, F=folate, PEG=polyethylene glycol. Supporting information for this article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704121_s.pdf or from author....
To maximize the efficacy of anticancer drugs and minimize untoward side effects such as nonspecific toxicity development multi-drug resistance, nano-sized drug delivery systems have been revolutionized by introducing triggering mechanisms for release. This will increase feasibility obtaining local high-dose therapy in cancerous tissues at intracellular compartments. Such technology requires highly sophisticated strategies which perform desired chemical/physical functions depending on...
In this study, a transferrin (Tf)-conjugated polymeric nanoparticle was developed for the targeted delivery of chemotherapeutic agent doxorubicin (Dox) in order to overcome multi-drug resistance cancer treatment. Our objective improve Dox producing significant antitumor efficacy Dox-resistant (R) breast cell lines with minimum toxicity healthy cells. The results our experiments revealed that successfully loaded inside composed poloxamer 407 (F127) and 123 (P123) (Dox/F127&P123-Tf), which...
Intravenously administered for the treatment of rectum cancer, irinotecan produces severe side effects due to very high plasma concentrations. A novel irinotecan-encapsulated double reverse thermosensitive nanocarrier system (DRTN) rectal administration was developed as an alternative. The DRTN fabricated by dispersing solid lipid nanoparticles (SLN) in poloxamer solution. Its gel properties, pharmacokinetics, morphology, anticancer activity and immunohistopathology were assessed after its...
Photothermal therapy (PTT) is performed using near-infrared-responsive agents, which proven to be an effective therapeutic strategy against cancer with several advantages including minimal invasion, high effectiveness, and easy implementation. Herein, we report a facile novel one-pot synthetic approach for the fabrication of polydopamine-folate carbon dots (PFCDs) as theranostic nanocarriers image-guided PTT targeting prostate (PCa) cells that express prostate-specific membrane antigen...