A5074045641- Nanoparticle-Based Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Surfactants and Colloidal Systems
- RNA Interference and Gene Delivery
- Polymer Surface Interaction Studies
- Dendrimers and Hyperbranched Polymers
- Synthesis and properties of polymers
- Analytical Chemistry and Chromatography
- Analytical Chemistry and Sensors
- Hydrogels: synthesis, properties, applications
- HIV Research and Treatment
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Nanocluster Synthesis and Applications
- Conducting polymers and applications
- Advanced Nanomaterials in Catalysis
- DNA and Nucleic Acid Chemistry
- Advanced Drug Delivery Systems
- Respiratory viral infections research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Research and Treatment
- HER2/EGFR in Cancer Research
- Lanthanide and Transition Metal Complexes
- Fuel Cells and Related Materials
University of Nebraska Medical Center
2015-2024
Boston University
2024
Universidad del Noreste
2023-2024
Northeastern University
2023-2024
Nebraska Medical Center
2013-2023
Lomonosov Moscow State University
2003-2017
Fred and Pamela Buffett Cancer Center
1997-2015
Susan Thompson Buffett Foundation
1997-2015
VA Nebraska Western Iowa Health Care System
2014
McGill University
1996-2008
Block ionomer complexes formed between the block copolymers containing poly(sodium methacrylate) (PMANa) and poly(ethylene oxide) (PEO) segments poly(N-ethyl-4-vinylpyridinium bromide) (PEVP) were investigated. The data obtained suggest that (i) these systems form water-soluble stoichiometric complexes; (ii) are stable in a much broader pH range compared to polyelectrolyte prepared from homopolymers; (iii) they self-assemble core of micelle comprised neutralized polyions, surrounded by PEO...
A star polymer composed of amphiphilic block copolymer arms has been synthesized and characterized. The core the is polyamidoamine (PAMAM) dendrimer, inner in arm lipophilic poly(epsilon-caprolactone) (PCL), outer hydrophilic poly(ethylene glycol) (PEG). star-PCL was first by ring-opening polymerization epsilon-caprolactone with a PAMAM-OH dendrimer as initiator. PEG then attached to PCL terminus an ester-forming reaction. Characterization SEC, (1)H NMR, FTIR, TGA, DSC confirmed structure...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSpontaneous Formation of Vesicles from Complexes Block Ionomers and SurfactantsA. V. Kabanov, T. K. Bronich, A. Yu, EisenbergView Author Information Department Pharmaceutical Sciences University Nebraska Medical Center Omaha, 68198 Polymer Sciences, Moscow State 119899, Russia Chemistry, McGill Montreal, Quebec, Canada H3A 2K6 Cite this: J. Am. Chem. Soc. 1998, 120, 38, 9941–9942Publication Date (Web):September 10, 1998Publication History...
This work reports the design of polymer micelles with cross-linked ionic cores that display high stability. Block ionomer complexes were utilized as a micellar template for synthesis micelles. Such represent hydrophilic nanospheres core−shell morphology. The core comprises network polyanions, which is surrounded by shell PEO chains.
The cationic copolymers for DNA delivery were synthesized by conjugating poly(ethylene glycol) (PEG) and polyamines: polyspermine (PSP) polyethyleneimine (PEI). These molecules spontaneously form electrostatic complexes with a model 24-mer phoshorothioate oligonucleotide, T24 (PS−ODN). copolymer are water soluble. This is marked contrast the formed nonmodified PSP PEI, which immediately precipitate out of solution. potentiometric titration study suggests that amino groups cooperative system...
Complexes from poly(ethylene oxide)-b-poly(sodium methacrylate) (PEO-b-PMANa) and N-alkylpyridinium bromides are water soluble, in marked contrast to those poly(sodium methacrylate). These systems studied using potentiometric titration, microcalorimetry, ζ-potential measurement, light scattering electron microscopy. Three regions (A−C) observed with a complex PEO-b-PMANa cetylpyridinuim bromide (C16PyBr) when the composition of mixture (Z = [C16PyBr]/[COO-]) is varied. (A) At Z < 1 C16PyBr...
Selective delivery of antioxidants to the substantia nigra pars compacta (SNpc) during Parkinson's disease (PD) can potentially attenuate oxidative stress and as such increase survival dopaminergic neurons. To this end, we developed a bone-marrow-derived macrophage (BMM) system deliver catalase PD-affected brain regions in an animal model human disease. preclude BMM-mediated enzyme degradation, was packaged into block ionomer complex with cationic copolymer, polyethyleneimine-poly(ethylene...
Many effective drugs for cancer treatment are poorly water-soluble. In combination chemotherapy, needed excipients in additive formulations often toxic and restrict their applications clinical intervention. Here, we report on amphiphilic poly(2-oxazoline)s (POx) micelles as a promising high capacity delivery platform multidrug chemotherapy. A variety of binary ternary combinations paclitaxel (PTX), docetaxel (DTX), 17-allylamino-17-demethoxygeldanamycin (17-AAG), etoposide (ETO) bortezomib...