A5028695008- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Graphene and Nanomaterials Applications
- Hydrogels: synthesis, properties, applications
- Lanthanide and Transition Metal Complexes
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Molecular Sensors and Ion Detection
- Protein Interaction Studies and Fluorescence Analysis
- Metal complexes synthesis and properties
- Cancer Treatment and Pharmacology
- biodegradable polymer synthesis and properties
- Polymer Surface Interaction Studies
- Dendrimers and Hyperbranched Polymers
- Advancements in Transdermal Drug Delivery
- Microencapsulation and Drying Processes
- Advanced Polymer Synthesis and Characterization
- Glycosylation and Glycoproteins Research
- Photosynthetic Processes and Mechanisms
- Influenza Virus Research Studies
- Nanoparticles: synthesis and applications
- Protein purification and stability
- Algal biology and biofuel production
- Gold and Silver Nanoparticles Synthesis and Applications
AbbVie (United States)
2022-2024
College of Lake County
2015
University of Nebraska Medical Center
2009-2013
Nebraska Medical Center
2011-2013
Guru Gobind Singh Indraprastha University
2009
Targeted drug delivery using multifunctional polymeric nanocarriers is a modern approach for cancer therapy. Our purpose was to prepare targeted nanogels selective of chemotherapeutic agent cisplatin luteinizing hormone-releasing hormone (LHRH) receptor overexpressing tumor in vivo. Building blocks such systems consisted innovative soft block copolymer with ionic cores serving as reservoir (loading 35%) and synthetic analogue LHRH conjugated the via poly(ethylene glycol) spacer. Covalent...
Abstract: Polymer micelles with cross-linked ionic cores are shown here to improve the therapeutic performance of platinum-containing anticancer compound cisplatin. Biodistribution, antitumor efficacy, and toxicity cisplatin-loaded core poly(ethylene glycol)- b -poly(methacrylic acid) were evaluated in a mouse ovarian cancer xenograft model. Cisplatin-loaded demonstrated prolonged blood circulation, increased tumor accumulation, reduced renal exposure. Improved response relative free drug...
Polymer nanogels have gained considerable attention as a potential platform for drug delivery applications. Here we describe the design and synthesis of novel polypeptide-based with hydrophobic moieties in cross-linked ionic cores. Diblock copolymer, poly(ethylene glycol)-b-poly(L-glutamic acid), hydrophobically modified L-phenylalanine methyl ester was used controlled template small size (ca. 70 nm diameter) narrow particle distribution. Steady-state time-resolved fluorescence studies using...
The therapeutic performance of oxaliplatin can be improved by incorporating the central cis-dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt) motif into core cross-linked block copolymer micelles. We describe here preparation, cellular uptake, and in vivo evaluation micelles loaded with DACHPt. Stable drug-loaded were prepared at high drug loading (~25 w/w%) displayed a considerably increased vitro cytotoxicity compared to free against A2780 ovarian cancer cells. DACHPt-loaded micelle...
Amorphous solid dispersions (ASDs) are an enabling formulation approach used to enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich amorphous nanoparticles generated situ during ASD dissolution maintain supersaturation that drives enhanced absorption. However, formation requires large quantities polymers release drugs rapidly, resulting load <25%. Delivering directly engineered drug-rich can reduce the significantly without sacrificing bioavailability....
The intestinal mucosal barrier forms a critical interface between lumen contents such as bacteria, drugs, and drug carriers the underlying tissue. Current in vitro models, while recapitulating certain aspects of this barrier, generally present challenges with respect to imaging transport across mucus uptake into enterocytes. A human mesofluidic small chip was designed enable facile visualization created by growing primary cells on vertical hydrogel wall separating channels representing...
Abstract ErbB2-driven breast cancers account for 20-25% of Breast Cancer patients screened in the USA. The humanized monoclonal antibody, Trastuzumab (Herceptin™), combination with chemotherapy is current standard treatment. However, newer agents to overcome challenges associated de novo and acquired resistance therapy, are being explored. HSP90 inhibitor, 17-allylaminodemethoxygeldanamycin (17-AAG), which recently completed phase II clinical trials, an example. Despite potent anti-cancer...