A5014585172- Antimicrobial Peptides and Activities
- Antifungal resistance and susceptibility
- Probiotics and Fermented Foods
- Polymer Surface Interaction Studies
- Biochemical and Structural Characterization
- Orthopedic Infections and Treatments
- Antimicrobial agents and applications
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Periodontal Regeneration and Treatments
- Enterobacteriaceae and Cronobacter Research
- Microencapsulation and Drying Processes
- Bone Tissue Engineering Materials
AbbVie (United States)
2023
University of Wisconsin–Madison
2015-2020
Candida albicans is the most prevalent cause of hospital-acquired fungal infections and forms biofilms on indwelling medical devices that are notoriously difficult to treat or remove. We recently demonstrated colonization C. surfaces catheter tube segments can be reduced in vitro by coating them with polyelectrolyte multilayers (PEMs) release a potent antifungal β-peptide. Here, we report impact polymer structure film composition both inherent β-peptide-mediated ability PEM-coated catheters...
Candida albicans is an opportunistic fungal pathogen responsible for mucosal candidiasis and systemic candidemia in humans. Often, these infections are associated with the formation of drug-resistant biofilms on surfaces tissues or medical devices. Increased incidence C. resistance to current antifungals has heightened need new strategies prevent eliminate biofilm-related infections.
ABSTRACT Staphylococcus aureus infections represent the major cause of titanium based-orthopaedic implant failure. Current treatments for S. involve systemic delivery antibiotics and additional surgeries, increasing health-care costs affecting patient’s quality life. As a step toward development new strategies that can prevent these infections, we build upon previous work demonstrating colonization catheters by fungal pathogen Candida albicans be prevented coating them with thin polymer...