A5025070309- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- 3D Printing in Biomedical Research
- Synthesis and properties of polymers
- Hydrogels: synthesis, properties, applications
- biodegradable polymer synthesis and properties
- Dendrimers and Hyperbranched Polymers
- Chemical Synthesis and Analysis
- Surfactants and Colloidal Systems
- Click Chemistry and Applications
- Additive Manufacturing and 3D Printing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Sensor and Energy Harvesting Materials
- Supramolecular Self-Assembly in Materials
- Polymer Surface Interaction Studies
- Graphene and Nanomaterials Applications
- Nanomaterials and Printing Technologies
- Biopolymer Synthesis and Applications
- Advanced NMR Techniques and Applications
- Synthetic Organic Chemistry Methods
- Electrospun Nanofibers in Biomedical Applications
- Conducting polymers and applications
- Analytical Chemistry and Chromatography
- Nanofabrication and Lithography Techniques
- Drug Solubulity and Delivery Systems
University of Helsinki
2020-2025
University of Würzburg
2015-2025
Institute of Molecular Functional Materials
2020-2023
Bavarian Polymer Institute
2016-2021
Technische Universität Dresden
2009-2016
University of Nebraska Medical Center
2008-2012
Technical University of Munich
2005-2011
Johannes Gutenberg University Mainz
2008
The University of Sydney
2005
Synthetic methods in polymer chemistry have evolved tremendously during the last decade. Nowadays more and attention is devoted to application of those tools development next generation nanomedicines. Nevertheless, poly(ethylene glycol) (PEG) remains most frequently used for biomedical applications. In this review, we try summarize recent efforts developments controlled polymerisation techniques that may allow alternatives PEG based systems can be improve properties future therapeutics.
Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC) limits drug penetration into the tumor and is associated with poor prognosis. Here, we demonstrate that a pretreatment based on proteolytic-enzyme nanoparticle system disassembles dense PDAC collagen stroma increases tumor. More specifically, collagozome, 100 nm liposome encapsulating collagenase, was rationally designed to protect collagenase from premature deactivation prolonged its release rate at target...
A new 2-oxazoline with a pendant alkyne moiety, 2-(pent-4-ynyl)-2-oxazoline, 1 (PynOx), was synthesized from commercial available compounds. Polymerization of PynOx methyl triflate as initiator and copolymerization 2-methyl- or 2-ethyl-2-oxazoline (MeOx EtOx) comonomers results in well-defined water-soluble polymers narrow molar mass distributions predefined degrees polymerization. Since the moiety is compatible living cationic polymerization, no protection group needed. The consecutive...
Abstract POx bottle‐brush brushes (BBBs) are synthesized by SIPGP of 2‐isopropenyl‐2‐oxazoline and consecutive LCROP 2‐oxazolines on 3‐aminopropyltrimethoxysilane‐modified silicon substrates. The side chain hydrophilicity polarity varied. impact the chemical composition architecture BBB upon protein (fibronectin) adsorption endothelial cell adhesion investigated prove extremely low BBBs with hydrophilic chains such as poly(2‐methyl‐2‐oxazoline) poly(2‐ethyl‐2‐oxazoline). influence terminal...
Preparation of defined and functional polymers has been one the hottest topics in polymer science drug delivery recent decade. Also, research on (bio)degradable gains more interest, particular at interface these two disciplines. However, majority cases, combination definition, functionality degradability, is problematic. Here we present preparation characterization (MALDI–ToF MS, NMR, GPC) nonionic hydrophilic, hydrophobic, amphiphilic N-substituted polyglycines (polypeptoids), which are...
Defined aggregates of polymers such as polymeric micelles are great importance in the development pharmaceutical formulations. The amount drug that can be formulated by a delivery system is an important issue, and most systems suffer from their relatively low drug-loading capacity. However, loading capacities increase, i.e., promoted good drug-polymer interactions, may affect morphology stability micellar system. We investigated this effect prominent with very high capacity for hydrophobic...
We report on the synthesis and characterization of cylindrical molecular brushes based poly(2-oxazoline)s (POx). The dual-functional monomer, 2-isopropenyl-2-oxazoline (IPOx), was first converted to a poly(2-isopropenyl-2-oxazoline), backbone by free radical (PIPOxR) or living anionic polymerization (PIPOxA). Quantitative reaction with methyl triflate yields macroinitiator salt (PIPOxOTfR/A) for preparation via grafting from approach cationic 2-oxazolines (2-methyl-, 2-ethyl-,...
Melt electrospinning writing (MEW), a computer-aided fiber deposition process based on an electrohydrodynamic working principle, enables the rational design and fabrication of fibrous scaffolds with micrometer thin fibers. So far, MEW has mainly been applied for poly(ε-caprolactone). Here we manufactured poly(2-ethyl-2-oxazoline), hydrophilic polymer high melting temperature, by first time. We systematically varied investigated crucial instrument parameters: heating temperature (200–220 °C),...
Many effective drugs for cancer treatment are poorly water-soluble. In combination chemotherapy, needed excipients in additive formulations often toxic and restrict their applications clinical intervention. Here, we report on amphiphilic poly(2-oxazoline)s (POx) micelles as a promising high capacity delivery platform multidrug chemotherapy. A variety of binary ternary combinations paclitaxel (PTX), docetaxel (DTX), 17-allylamino-17-demethoxygeldanamycin (17-AAG), etoposide (ETO) bortezomib...
ABSTRACT Precision synthesis of polymers has been a hot topic in recent years. While this is notoriously difficult to address for with CC backbone, Merrifield discovered way many decades ago polypeptides. Using similar approach, N‐substituted polypeptides, so‐called polypeptoids have synthesized and studied about 20 In contrast, the living ring‐opening polymerization (ROP) N‐carboxyanhydrides was among first polymerizations be discovered. More recently, surge new synthetic approaches led...
Biocompatible polymers that form thermoreversible supramolecular hydrogels have gained great interest in biomaterials research and tissue engineering. When favorable rheological properties are achieved at the same time, they particularly promising candidates as material allow for printing of cells, so-called bioinks. We synthesized a novel thermogelling block copolymer investigated its aqueous solution by viscosimetry rheology. The undergo thermogelation between room temperature body...
Polymer micelles offer the possibility to create a nanoscopic environment that is distinct from bulk phase. They find applications in catalysis, drug delivery, cleaning, etc. Often, one simply distinguishes between hydrophilic and hydrophobic, but fine-tuning of microenvironment possible by adjusting structure polymer amphiphile. Here, we investigated small library structurally similar amphiphiles based on poly(2-oxazoline)s poly(2-oxazine)s with respect their solubilization capacity for two...
Despite decades of research, our understanding the molecular interactions between drugs and polymers in drug-loaded polymer micelles does not extend much beyond concepts such as "like-dissolves-like" or hydrophilic/hydrophobic. However, polymer–drug compatibility strongly affects formulation properties therefore translation a into clinics. Specific hydrogen-bonding, π–π stacking, coordination can be utilized to increase drug loading. This is commonly based on trial error eventually leads an...
Polymeric micelles are typically characterized as core–shell structures. The hydrophobic core is considered a depot for molecules, and the corona-forming block acts stabilizing solubilizing interface between aqueous milieu. Tremendous efforts have been made to tune increase drug loading stability of micelles, whereas role hydrophilic blocks rarely investigated in this context, with poly(ethylene glycol) (PEG) being gold standard polymers. To better understand corona, small library...