A5101595357- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Photodynamic Therapy Research Studies
- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Hydrogels: synthesis, properties, applications
- Polymer Surface Interaction Studies
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Advanced Polymer Synthesis and Characterization
- Protein Interaction Studies and Fluorescence Analysis
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Gold and Silver Nanoparticles Synthesis and Applications
- Drug Transport and Resistance Mechanisms
- Drug Solubulity and Delivery Systems
- Dendrimers and Hyperbranched Polymers
- Surfactants and Colloidal Systems
- biodegradable polymer synthesis and properties
- Proteoglycans and glycosaminoglycans research
- Supramolecular Chemistry and Complexes
- Luminescence and Fluorescent Materials
- Electrospun Nanofibers in Biomedical Applications
- Fullerene Chemistry and Applications
Catholic University of Korea
2016-2025
Korea Institute of Ocean Science and Technology
2024-2025
Government of the Republic of Korea
2015-2021
Bucheon St. Mary's Hospital
2016-2021
Bucheon University
2014-2021
Sungkyunkwan University
2010-2019
Korea University of Science and Technology
2015
Jeonbuk National University
2014-2015
Korea Research Institute of Standards and Science
2014
Georgia Institute of Technology
2010
To endow enhanced tumor specificity and endosome disruption property on the carrier, a multifunctional polymeric micelle was investigated. The exposes cell interacting ligand (biotin) surface under slightly acidic environmental conditions of various solid tumors is internalized by biotin receptor-mediated endocytosis in short time period. also showed pH-dependent dissociation, causing release doxorubicin from carrier early endosomal pH. dissociated micellar components subsequently disrupt membrane.
An optimized, pH-sensitive mixed-micelle system conjugated with folic acid is prepared in order to challenge multidrug resistance (MDR) cancers. The micelles are composed of poly(histidine (His)-co-phenylalanine (Phe))-b-poly(ethylene glycol) (PEG) and poly(L-lactic acid) (PLLA)-b-PEG-folate. Core-forming, hydrophobic blocks poly(His-co-Phe) varying composition synthesized. pH sensitivity the controlled by copolymer fine tuned early endosomal blending PLLA(3K)-b-PEG(2K)-folate presence a...
Self-repairable materials strive to emulate curable and resilient biological tissue; however, their performance is currently insufficient for commercialization purposes because mending toughening are mutually exclusive. Herein, we report a carbonate-type thermoplastic polyurethane elastomer that self-heals at 35 °C exhibits tensile strength of 43 MPa; this as strong the soles used in footwear. Distinctively, it has abundant carbonyl groups soft-segments fully amorphous with negligible phase...
Sharper image: A newly developed polysaccharide/drug conjugate (see picture) responds to changes in pH value and was shown penetrate HeLa tumors mice as determined by fluorescence imaging. It has the potential be used photodynamic therapy, thereby targeting tumor while having no detrimental effects on surrounding tissue. Detailed facts of importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available...
Rabies virus-inspired silica-coated gold nanorods are fabricated by mimicking size, shape, surface glycoprotein property and in vivo behavior of the rabies virus. These not only resemble appearance actual virus but also travel into brain through neuronal pathway bypassing blood–brain barrier, moreover respond to near-infrared laser (808 nm) irradiation, emit heat, effectively suppress tumors. As a service our authors readers, this journal provides supporting information supplied authors....
Delivering the goods: A pH-sensitive nanogel consists of a hydrophobic copolymer core and two layers hydrophilic shell (see picture). The is loaded with model anticancer drug, doxorubicin (DOX). infects tumor cells in receptor-dependent manner, kills cells, migrates to neighboring like virus. BSA=bovine serum albumin, F=folate, PEG=polyethylene glycol. Supporting information for this article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704121_s.pdf or from author....
To maximize the efficacy of anticancer drugs and minimize untoward side effects such as nonspecific toxicity development multi-drug resistance, nano-sized drug delivery systems have been revolutionized by introducing triggering mechanisms for release. This will increase feasibility obtaining local high-dose therapy in cancerous tissues at intracellular compartments. Such technology requires highly sophisticated strategies which perform desired chemical/physical functions depending on...
The second generation of pH-sensitive micelles composed poly(l-histidine-co-l-phenlyalanine(16 mol %))(MW:5K)-b-PEG(MW:2K) and poly(l-lactic acid)(MW:3K)-b-PEG(MW:2K)-folate (80/20 wt/wt %) was previously optimized by physicochemical in vitro tests for both folate receptor early endosomal pH targeting (pH approximately 6.0). In this study, the therapeutic efficacy doxorubicin (DOX)-loaded (DOX loading content: 20 wt evaluated using vivo tests. Multidrug-resistant (MDR) ovarian...
Food packaging requirements of gas barrier and self-cleaning are satisfied with the use bio-renewable cellulose, chitosan, silica, sunflower oil.
A new molecular dynamics for transparent and self-healing elastomers are developed that uses aliphatic disulfide H-bond acceptors to produce colorless waterproof coatings, particularly in display applications.