A5068624505- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Polymer Surface Interaction Studies
- Proteoglycans and glycosaminoglycans research
- Supramolecular Self-Assembly in Materials
- Hydrogels: synthesis, properties, applications
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Luminescence and Fluorescent Materials
- Supramolecular Chemistry and Complexes
- Peptidase Inhibition and Analysis
Catholic University of Korea
2018-2020
In this study, we developed an extremely small-sized water-soluble hyaluronate dot (dHA) conjugated with cyclic RGD (cRGD) and cleavable doxorubicin (DOX, as a model antitumor drug), named cRGD@dHA-c-DOX. This HA moieties (as specific ligands to tumor CD44 receptors) cRGD integrin αvβ3) was designed enable multivalent targeting. particular, the imine bonds, linking DOX dHA, can exhibit cleavage performance at endosomal pH, resulting in pH-triggered release from We demonstrated that...
In this study, we report pH‐responsive polysaccharidic nanogels comprising starch grafted with 3‐(diethylamino)propylamine (DEAP, as an inner soft nanogel core) and poly(ethylene glycol) (PEG, outer hydrophilic shell). Here, the DEAP moieties (pK b ~ pH 7.0) enhance lipophilicity of core at 7.4, improving loading efficiency antitumor model drug (docetaxel [DTX]) in core. However, could be protonated below 7.0, resulting mediation ion‐dipole interactions hydroxyl groups abundant backbone....
In this study, we report pH‐responsive porous polysaccharide nanoparticles (NPs) for tumor‐specific photodynamic therapy. Herein, γ‐cyclodextrin (γCD) conjugated with 3‐(diethylamino)propylamine (DEAP, as a moiety) and poly(ethylene glycol) (PEG) was used to fabricate γCD‐(DEAP/PEG) NPs using self‐assembling process γCD PEG hydrophilic segment DEAP hydrophobic segment. These contain rich pore channels, allowing the facile encapsulation of chlorin e6 (Ce6, model drug) via host‐guest...
Gold nanoparticles with various functionalities have served as potential tools in nanotechnology for tumor ablation. In this work, we seek to design and develop gold nanoparticle poly(ethylene glycol)-containing dopamine (hereafter termed AuND), synthesize the AuND one-sided Tat peptide expression (OT@AuND). We demonstrate cell-targeting ability on basis of anti-nonspecific cell binding OT@AuND determine how chemically modified nanoparticle–based product affects photothermal therapy vitro...