A5049048787- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Protease and Inhibitor Mechanisms
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Angiogenesis and VEGF in Cancer
- Proteoglycans and glycosaminoglycans research
- Coronary Interventions and Diagnostics
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Polymer Surface Interaction Studies
- Advanced Nanomaterials in Catalysis
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Tendon Structure and Treatment
- Photodynamic Therapy Research Studies
- Inflammatory mediators and NSAID effects
- Bone health and treatments
- Phagocytosis and Immune Regulation
- Immune cells in cancer
Chung-Ang University
2017-2025
Korea Institute of Science and Technology
2004-2023
Catholic University of Korea
2007-2018
Yonsei University
2018
Bucheon St. Mary's Hospital
2018
Korea Basic Science Institute
2012-2017
Korea Advanced Institute of Science and Technology
2003-2014
Korea University
2008-2014
Hanyang University
2014
Chungnam National University Hospital
2013
Abstract Advances in nanotechnology have contributed to the development of novel nanoparticles that enable tumor‐specific delivery imaging probes and therapeutic agents cancer therapy. Nanobiotechnology combines with molecular imaging, which has led generation new multifunctional for Multifunctional hold great promise future treatment because they can detect early onset each individual patient deliver suitable enhance efficacy. The combination tumor‐targeted therapy an all‐in‐one system...
Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected—both in vitro vivo. Experiments disclose an apparent positive contrast MMPs-positive tumor-bearing mice (right). Supporting information for article available on WWW under...
Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses in the global swine industry due to its high genetic diversity different virulence levels, which complicate disease management vaccine development. This study evaluated longitudinal changes immune cell composition of bronchoalveolar lavage fluid clinical outcomes across PRRSV strains with varying virulence, using techniques including single-cell transcriptomics. In highly virulent infection, faster...
We report tumor targeting nanoparticles for optical/MR dual imaging based on self-assembled glycol chitosan to be a potential multimodal probe. To develop an probe, biocompatible and water-soluble (Mw = 50 kDa) were chemically modified with 5β-cholanic acid (CA), resulting in amphiphilic chitosan-5β-cholanic conjugates (GC-CA). For optical near-infrared fluorescence (NIRF) dye, Cy5.5, was conjugated GC-CA Cy5-labeled (Cy5.5-GC-CA). Moreover, order chelate gadolinium (Gd(III)) the Cy5.5-GC-CA...
We report here a new protease activatable strategy based on polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration an MMP-positive SCC-7 xenograft tumor and colon cancer mouse model verified enzyme specificity The design platform is flexible can be fine-tuned for wide array applications such as detection biomarkers, early diagnosis disease,...
Lipid droplet (LD) accumulation, a key feature of foam cells, constitutes an attractive target for therapeutic intervention in atherosclerosis. However, despite advances cellular imaging techniques, current noninvasive and quantitative methods have limited application living cells. Here, using optical diffraction tomography (ODT), we performed morphological biophysical analysis cells label-free manner. We identified LDs by verifying the specific refractive index correlative comprising ODT...
Various deoxycholic acid (DOCA) bearing heparin (HD) amphiphilic conjugates with different degrees of substitution (DS) DOCA were synthesized using as a hydrophilic segment and hydrophobic segment. Structural characteristics these HD investigated 1H NMR, dynamic light scattering, zeta potential, transmission electron microscopy (TEM), fluorescence spectroscopy. provided monodispersed self-aggregates in water, mean diameters decreasing increasing DS the range 120-200 nm. aggregates covered...