A5047035980- Nanoplatforms for cancer theranostics
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Perovskite Materials and Applications
- Peripheral Artery Disease Management
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Photodynamic Therapy Research Studies
- Angiogenesis and VEGF in Cancer
- Medical Imaging and Pathology Studies
- Conducting polymers and applications
- Quantum Dots Synthesis And Properties
- Advanced Nanomaterials in Catalysis
- Phagocytosis and Immune Regulation
- Solid-state spectroscopy and crystallography
- Protease and Inhibitor Mechanisms
- Extracellular vesicles in disease
- Advanced Fluorescence Microscopy Techniques
- Bone Tissue Engineering Materials
- Tuberculosis Research and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Digital Holography and Microscopy
- Nasal Surgery and Airway Studies
- Bone and Dental Protein Studies
- Molecular Biology Techniques and Applications
Chung-Ang University
2018-2024
Catholic University of Pusan
2024
Korea University
2024
Lipid droplet (LD) accumulation, a key feature of foam cells, constitutes an attractive target for therapeutic intervention in atherosclerosis. However, despite advances cellular imaging techniques, current noninvasive and quantitative methods have limited application living cells. Here, using optical diffraction tomography (ODT), we performed morphological biophysical analysis cells label-free manner. We identified LDs by verifying the specific refractive index correlative comprising ODT...
Abstract The preferential growth of α‐phase formamidinium perovskite (α‐FAPbI 3 ) at low temperatures can be achieved with the incorporation chloride‐based additives, methylammonium chloride (MACl) being most common example. However, compared to other less‐volatile MACl only remains in growing film for a short time before evaporating during annealing, primarily influencing early stages formation. In addition, evaporation as methylamine (MA 0 and HCl introduce side reaction between MA (FA),...
Inflammation plays a pivotal role in the pathogenesis of acute coronary syndrome. Detecting plaques with high inflammatory activity and specifically treating those lesions can be crucial to prevent life-threatening cardiovascular events.
In this study, a novel three-dimensional (3D) bone morphogenic protein-2 (BMP-2)-delivering tannylated polycaprolactone (PCL) (BMP-2/tannic acid (TA)/PCL) scaffold with anti-oxidant, anti-inflammatory, and osteogenic activities was fabricated via simple surface coating TA, followed by the immobilization of BMP-2 on TA-coated PCL scaffold. The BMP-2/TA/PCL showed controlled sustained release. It effectively scavenged reactive oxygen species (ROS) in cells, increased proliferation MC3T3-E1...
Photoactivation targeting macrophages has emerged as a therapeutic strategy for atherosclerosis, but limited targetable ability of photosensitizers to the lesions hinders its applications. Moreover, molecular mechanistic insight phototherapeutic effects on atheroma is still lacking. Herein, we developed macrophage near-infrared fluorescence (NIRF) emitting phototheranostic agent by conjugating dextran sulfate (DS) chlorin e6 (Ce6) and estimated feasibility in murine atheroma. Also,...
Macrophage-derived foam cells play critical roles in the initiation and progression of atherosclerosis. Activated macrophages are important biomarkers for targeted imaging inflammatory disease therapy. Macrophages also express dectin-1 receptor, which specifically recognizes β-glucan (Glu). Here, we prepared photoactivatable nanoagents (termed Glu/Ce6 nanocomplexes) by encapsulating hydrophobic chlorin e6 (Ce6) within triple-helix structure Glu aqueous condition. nanocomplexes generate...
Abstract In p–i–n perovskite solar cells (PSCs), fullerene derivatives are predominantly used as an electron transport material (ETM) despite their disadvantages, such parasitic absorption in the short wavelength range and high cost. State‐of‐the‐art n‐i‐p PSCs fabricated using SnO 2 ETM due to charge transfer ability, transparency, low However, PSCs, dispersing nanoparticles a solvent that does not damage forming uniform layer is challenging. Herein, strategy of directly depositing quantum...
Purified tuberculin protein-π prepared from unclassified mycobacteria and human tubercle bacillus was examined on 4,461 normal healthy persons 391 tuberculous inpatients of the some hospitals in Korea during 1963 to 1964.The results obtained group are as follow: The rate positive reaction found be 0.9 6.2 percent primary school children, 0.2 7.7 middle pupil, 0.4 5.7 college students. older age examined, lower became reaction. Positive rates observed three different purified...
Background: When a body is discovered at crime or murder scene, it crucial to examine the and estimate its postmortem interval (PMI). Accurate estimation of PMI vital for identifying suspects providing clues resolve case. MicroRNAs (miRNAs miRs) are small non-coding RNAs that remain relatively stable in cell nucleus even after death-related changes occur. Objective: This study developed molecular beacon probe mmu-miR-133a-5p assessed use mouse muscle tissue temperatures 4 °C 21 PMI. Methods:...
It is not easy to determine the cause of pulmonary consolidative lesion. Even without any definite mass, malignancy cannot be ruled out. And sometimes, it difficult differentiate tuberculosis from pneumonia. To malignant lesion benign one, we studied patterns air bronchogram, mucoid impaction, and computed tomographic angiogram etc. Fifty seven cases lesions(23 malignancy, 34 lesion) were retrospectively reviewed by three radiologists. Among 28 which showed a little bronchogram(less than 1/3...
Introduction and Hypothesis: Arterial healing following stent implantation involves a series of biological reactions such as thrombosis, inflammation, neointimal regeneration. Clinical evidences have shown favorable arterial after thin-strut stents, however, there has been lack in vivo imaging evidence on how strut thickness affect vascular process. We evaluated local endothelial shear stress (ESS) response bioresorbable scaffold (BRS, 100μm) compared to first-generation 157μm-thickness...
Backgrounds: Atherosclerosis is a chronic inflammatory disease causing fatal plaque rupture and its key aspect failure to resolve inflammation. We hypothesized that macrophage targeted near-infrared fluorescence (NIRF) emitting photoactivation could simultaneously in vivo assess the inflamed high-risk plaques facilitate inflammation resolution. Method results: newly synthesized Dectin-1 photoactivatable theranostic agent by chemical conjugation of photosensitizer chlorin e6 (Ce6) ligand...
Photoactivation is a promising theranostic tool to image and stabilize the atherosclerotic plaque by apoptosis induction in macrophages or other vascular cells; however, lack of effective drugs mechanistic understanding hinder its clinical application for cardiovascular disease. Here, we developed macrophage targeted photosensitizer delivery strategy demonstrated that imaging assisted light activation reduced inflammation burden plaques. Mechanistically, photoactivation induced autophagy...
Introduction and Hypothesis: Photoactivation has emerged as an innovative therapeutic strategy for coronary high-risk plaque without metallic remnants, however, limited targetable ability of photoactivator lack imaging guidance hinders its application to clinics. To solve these unmet needs, we developed intravascular photoactivation guided by dual-modal OCT-NIRF structural-molecular using a novel theranostic NIRF-emitting photoactivator. Methods Results: Photoactivatable agent targeting...
Introduction: We evaluated local endothelial shear stress (ESS) distribution and arterial healing response of a thin-strut bioresorbable scaffold (BRS, 100μm) compared to 157μm-thickness ABSORB. Hypothesis: Thinner-strut design is known promote stent healing, however, there has been lack in vivo imaging evidence on how strut thickness affect process. Methods: BRS ABSORB were implanted left anterior descending circumflex arteries pigs (n=7). Detailed scaffolded-artery 3D model was...