A5100652725- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Blood Pressure and Hypertension Studies
- Cardiac electrophysiology and arrhythmias
- Optical Coherence Tomography Applications
- Vascular Procedures and Complications
- Cardiac Valve Diseases and Treatments
- Advanced Fluorescence Microscopy Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Artery Anomalies
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Photoacoustic and Ultrasonic Imaging
- Cardiac Health and Mental Health
Korea University Medical Center
2016-2025
Seoul National University Bundang Hospital
2020-2025
Korea University
2009-2024
Catholic University of Korea
2021
Wonkwang University
2020
St. Vincent's Hospital
2020
Chonnam National University Hospital
2020
Chungnam National University
2020
Pusan National University
2020
Kyungpook National University Hospital
2020
Epicardial Adipose Tissue in Atrial Fibrillation. Introduction: As epicardial adipose tissue (EAT) is a metabolically active visceral fat, potential interaction between EAT and myocardium strongly suggested. The aims of this study were to determine whether the amount regional distribution are related chronicity atrial fibrillation (AF) left (LA) remodeling. Methods Results: This consisted 40 subjects with paroxysmal AF (PAF) persistent (PeAF). Eighty no history enrolled as controls. Total...
Lipid droplet (LD) accumulation, a key feature of foam cells, constitutes an attractive target for therapeutic intervention in atherosclerosis. However, despite advances cellular imaging techniques, current noninvasive and quantitative methods have limited application living cells. Here, using optical diffraction tomography (ODT), we performed morphological biophysical analysis cells label-free manner. We identified LDs by verifying the specific refractive index correlative comprising ODT...
Limited data are available on short-term dual antiplatelet therapy (DAPT) after percutaneous coronary intervention using third-generation drug-eluting stents with ultrathin struts and advanced polymer technology. We investigated whether 3- to 6-month DAPT was noninferior 12-month implantation of technology.We performed an open-label, randomized trial at 37 centers in South Korea. enrolled patients undergoing the Orsiro biodegradable-polymer sirolimus-eluting or Coroflex ISAR polymer-free...
Lipid-rich inflamed coronary plaques are prone to rupture. The purpose of this study was assess lipid-rich in vivo using fully integrated high-speed optical coherence tomography (OCT)/near-infrared fluorescence (NIRF) molecular imaging with a Food and Drug Administration-approved indocyanine green (ICG).An intravascular OCT/NIRF catheter dual-modal system were constructed based on clinical OCT platform. For plaques, the NIRF-emitting ICG (2.25 mg/kg) or saline injected intravenously into...
Serum uric acid (UA) has been known to have a positive association with blood pressure (BP). However, the relationship between serum UA and BP in different age groups is unclear.A total of 45,098 Koreans who underwent health examinations at Korea Association Health Promotion no history taking drugs related and/or were analyzed for determining BP.In men <40, was significantly associated systolic (β = 0.25, p 0.002) diastolic 0.41, < 0.001) after adjustment age, diabetes, dyslipidemia, body...
Inflammation plays essential role in development of plaque disruption and coronary stent-associated complications. This study aimed to examine whether intracoronary dual-modal optical coherence tomography (OCT)-near-infrared fluorescence (NIRF) structural–molecular imaging with indocyanine green (ICG) can estimate inflammation swine artery. After administration clinically approved NIRF-enhancing ICG (2.0 mg/kg) or saline, rapid (20 mm/s pullback speed) using a fully integrated OCT-NIRF...
Abstract Aims Emotional stress is associated with future cardiovascular events. However, the mechanistic linkage of brain emotional neural activity acute plaque instability not fully elucidated. We aimed to prospectively estimate relationship between amygdalar (AmygA), arterial inflammation (AI), and macrophage haematopoiesis (HEMA) in myocardial infarction (AMI) as compared controls. Methods results 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT)...
Optical coherence tomography (OCT), an interferometric imaging technique, provides non-invasive, high-speed, high-sensitive volumetric biological in vivo. However, systemic features inherent the basic operating principle of OCT limit its performance such as spatial resolution and signal-to-noise ratio. Here, we propose a deep learning-based image enhancement framework that exploits raw interference fringes to achieve further from currently obtainable optimized images. The proposed for...
Importance Cardiovascular benefits of mild to moderate alcohol consumption need be validated in the context behavioral changes. The reduced among people who drink heavily across different subtypes cardiovascular disease (CVD) are unclear. Objective To investigate association between and risk major adverse events (MACEs) individuals CVD subtypes. Design, Setting, Participants This cohort study analyzed data from Korean National Health Insurance Service–Health Screening database self-reported...
Objectives. Pulse wave velocity (PWV) is an indicator of arterial stiffness, especially in the aorta, and a marker for vascular damage. Smoking reported to increase stiffness. We examined acute chronic effects smoking on stiffness by measuring brachial–ankle PWV (baPWV) using oscillometric method (VP 1000, Colin Co., Komaki, Japan). Methods. All healthy male subjects (chronic smokers, n = 40, 30.3 years old vs non‐smokers, 28.3 old) smoked two cigarettes (nicotine 1.5 mg) within 10 min...
Despite anticoagulation therapy, up to one-half of patients with deep vein thrombosis (DVT) will develop the post-thrombotic syndrome (PTS). Improving long-term outcome DVT at risk for PTS therefore require new approaches. Here we investigate effects statins—lipid-lowering agents anti-thrombotic and anti-inflammatory properties—in decreasing thrombus burden wall injury, mediators PTS, in established murine stasis non-stasis chemical-induced venous (N = 282 mice). Treatment mice daily...
Abstract Macrophages mediate atheroma expansion and disruption, denote high-risk arterial plaques. Therefore, they are substantially gaining importance as a diagnostic imaging target for the detection of rupture-prone Here, we developed an injectable near-infrared fluorescence (NIRF) probe by chemically conjugating thiolated glycol chitosan with cholesteryl chloroformate, NIRF dye (cyanine 5.5 or 7), maleimide-polyethylene glycol-mannose mannose receptor binding ligands to specifically...
Micro-optical coherence tomography (μOCT) is an advanced imaging technique that acquires a three-dimensional microstructure of biological samples with high spatial resolution, up to 1 μm, by using broadband light source and numerical aperture (NA) lens. As NA produces short depth focus (DOF), extending the DOF necessary obtain reasonable depth. However, due complexity optics limited space, it has been challenging fabricate endoscopic μOCT, which essential for clinical translation. Here, we...
Purpose: Intravascular optical coherence tomography (IV‐OCT) is a high‐resolution imaging method used to visualize the microstructure of arterial walls in vivo . IV‐OCT enables clinician clearly observe and accurately measure stent apposition neointimal coverage coronary stents, which are associated with side effects such as in‐stent thrombosis. In this study, authors present an algorithm for quantifying by automatically detecting lumen contours struts images. Methods: The utilizes OCT...
Abstract Fabry disease is an X-linked lysosomal storage caused by a mutation in the galactosidase alpha (GLA) gene. Despite advances therapeutic technologies, lack of humanized experimental models has limited development new therapies to cure disease. Herein, we modeled using human inducible pluripotent stem cell (iPSC)-derived kidney organoids and CRISPR–Cas9 genome-editing system. GLA-mutant revealed deformed podocytes tubular cells with accumulation globotriaosylceramide (Gb3)....
A novel near-infrared fluorescence (NIRF) copper sensor allows rapid and ultra-sensitive detection of ions with excellent selectivity specificity due to the click ligation effective dark-quenching mechanism.
Abstract Comprehensive imaging of both the structural and biochemical characteristics atherosclerotic plaque is essential for diagnosis study coronary artery disease because a plaque’s morphology its composition affect level risk it poses. Optical coherence tomography (OCT) fluorescence lifetime (FLIm) are promising optical methods characterizing plaques morphologically biochemically, respectively. In this study, we present hybrid intravascular device, including custom-built OCT/FLIm system,...
Inflammation plays a pivotal role in the pathogenesis of acute coronary syndrome. Detecting plaques with high inflammatory activity and specifically treating those lesions can be crucial to prevent life-threatening cardiovascular events.