A5100388894- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Metal and Thin Film Mechanics
- Diabetes Treatment and Management
- Nanoparticle-Based Drug Delivery
- Carbon Nanotubes in Composites
- Graphene research and applications
- Effects and risks of endocrine disrupting chemicals
- Supercapacitor Materials and Fabrication
- Plasma Diagnostics and Applications
- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Sirtuins and Resveratrol in Medicine
- Toxic Organic Pollutants Impact
- Advancements in Battery Materials
- Cancer Research and Treatments
- Copper Interconnects and Reliability
- Carcinogens and Genotoxicity Assessment
- Autophagy in Disease and Therapy
- Phagocytosis and Immune Regulation
- Virus-based gene therapy research
- Semiconductor materials and devices
- Click Chemistry and Applications
- Air Quality and Health Impacts
- Synthesis and biological activity
Hongik University
2024
Korea Advanced Institute of Science and Technology
2018-2024
Sungkyunkwan University
2012-2023
Korean Academy of Science and Technology
2021
Jeonbuk National University
2019
Institute for Basic Science
2013-2016
Johns Hopkins University
2013-2015
Pusan National University
2008-2013
National Institute of Biomedical Imaging and Bioengineering
2010
Korea Institute of Science and Technology
2008-2010
Asymmetric supercapacitors with high energy density are fabricated using a self‐assembled reduced graphene oxide (RGO)/MnO 2 (GrMnO ) composite as positive electrode and RGO/MoO 3 (GrMoO negative in safe aqueous Na SO 4 electrolyte. The operation voltage is maximized by choosing two metal oxides the largest work function difference. Because of synergistic effects highly conductive pseudocapacitive oxides, hybrid nanostructure electrodes exhibit better charge transport cycling stability....
The main obstacles to achieving high electrochemical energy density while retaining power are the trade-offs of versus and gravimetric volumetric density. Optimizing structural parameters is key circumvent these trade-offs. We report here synthesis carbon nanotube (CNT)-bridged graphene 3D building blocks via Coulombic interaction between positively charged CNTs grafted by cationic surfactants negatively oxide sheets, followed KOH activation. were intercalated into nanoporous layers build...
Abstract An ultrathin V 2 O 5 layer was electrodeposited by cyclic voltammetry on a self‐standing carbon‐nanofiber paper, which obtained stabilization and heat‐treatment of an electrospun polyacrylonitrile (PAN)‐based nanofiber paper. A very‐high capacitance 1308 F g −1 in M KCl electrolyte when the contribution from 3 nm thick vanadium oxide considered alone, contributing to over 90% total (214 ) despite low weight percentage (15 wt%). The high is attributed large external surface area...
Sirtuins (SIRTs), NAD+-dependent class III histone deacetylases (HDACs), play an important role in the regulation of cell division, survival and senescence. Although a number effective SIRT inhibitors have been developed, little is known about specific mechanisms their anticancer activity. In this study, we investigated effects sirtinol, inhibitor, on MCF-7 human breast cancer cells. Apoptotic autophagic death were measured. Sirtinol significantly inhibited proliferation cells...
Exposure and risk assessment was performed by evaluating levels of volatile organic compounds (VOC) benzene, toluene, ethylbenzene, xylene (BTEX) in 207 consumer products. The products were categorized into 30 different items, consisting brands. Samples analyzed for BTEX headspace-gas chromatography/mass spectrometry (headspace-GC/MS) with limit detection (LOD) 1 ppm. detected 59 from 18 item types. Benzene whiteout (ranging not [ND] to 3170 ppm), glue (1486 oil-based ballpoint pens (47...
Our goal in the present study was to evaluate whether decabromodiphenyl ether (BDE-209), which is most abundant polybrominated diphenyl (PBDE) found human samples, affects against target organs. Sprague-Dawley male rats were exposed vehicle or BDE-209 (100, 300, 600 mg/kg body weight, daily) from postnatal day (PND) 10 PND 42. There no significant difference and reproductive organ weight changes compared with controls. However, liver, thyroid adrenal gland weights significantly increased...
Abstract A physical route is proposed to obtain highly crystalline graphene sheets with minimal oxygen content similar the precursor graphite. The functional obtained from graphite oxide by low temperature thermal exfoliation are annealed at high (1900 °C) in a vacuum (10 −6 torr). D band intensity Raman spectroscopy reduced significantly, while G recovered, level of No appreciable observed X‐ray photoelectron and an electrical conductivity ∼56 500 S m −1 obtained, comparable 100 900
The transition from a chemotherapy-responsive cancer to chemotherapy-resistant one is accompanied by increased expression of multidrug resistance 1 (MDR1, <i>p</i>-glycoprotein), which plays an important role in the efflux target cell many anticancer agents. We recently showed that Forkhead box-containing protein O subfamily (FoxO1) key regulator <i>MDR1</i> gene transcription. Because nuclear localization FoxO1 regulated silent information two ortholog (SIRT1) deacetylase, we wondered...
Polybrominated diphenyl ethers (PBDE) are a class of brominated flame retardants that recognized as global environmental contaminants with potential adverse effects on human health. This study examined the prenatal exposure to PBDE reproductive organs, neuronal development, and levels thyroid hormones. Pregnant rats were exposed vehicle or deca-bromodiphenyl ether (BDE) (BDE-209; 5, 40, 320 mg/kg body weight/d) during gestation days (GD) 6-18. There was significant decrease in weight gain F1...
Abstract Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) is considered an attractive anticancer agent due to its tumor cell–specific cytotoxicity. However, low stability, solubility, unexpected side effects, and weak pharmacokinetic profiles restrict successful clinical application. To develop efficient TRAIL-based biotherapeutics, a new version of trimeric TRAIL was constructed by incorporating trimer-forming zipper sequences (HZ-TRAIL), then NH2-terminal–specific PEGylation...