A5063816631- Metabolism, Diabetes, and Cancer
- Natural product bioactivities and synthesis
- Urinary Tract Infections Management
- Sirtuins and Resveratrol in Medicine
- Phytochemistry and Biological Activities
- Ginseng Biological Effects and Applications
- Genomics, phytochemicals, and oxidative stress
- Bioactive natural compounds
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Phytochemical Studies and Bioactivities
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Research studies in Vietnam
- Cancer-related molecular mechanisms research
- Urinary Bladder and Prostate Research
- Polyamine Metabolism and Applications
- Cancer-related Molecular Pathways
- Crustacean biology and ecology
- PARP inhibition in cancer therapy
- Toxin Mechanisms and Immunotoxins
- Traditional Chinese Medicine Analysis
- Epigenetics and DNA Methylation
Lund University
2015-2025
Thai Binh University of Medicine and Pharmacy
2018-2024
Groupe Sociétés, Religions, Laïcités
2024
University of Massachusetts Chan Medical School
2023
Nagasaki University
2023
Nam Dinh University of Nursing
2020
Hanoi National University of Education
2019
John Wiley & Sons (United Kingdom)
2019
Hudson Institute
2019
Max Planck Institute for Heart and Lung Research
2017
Endothelial dysfunction is defined as impairment of the balance between endothelium-dependent vasodilation and constriction. Despite evidence uric acid-induced endothelial dysfunction, a relationship with insulin resistance has not been clearly established. In this study, we investigated role vascular in dysfunction. Uric acid inhibited insulin-induced nitric oxide synthase (eNOS) phosphorylation NO production more substantially than endothelin-1 expression HUVECs, IC50 51.0, 73.6, 184.2,...
Toll-like receptors (TLR) are critical mediators of the immune response to pathogens and human polymorphisms in this gene family regulate inflammatory pathways associated with susceptibility infection. Lipopeptides present a wide variety microbes stimulate responses through TLR1/2 or TLR2/6 heterodimers. It is not currently known whether TLR1 innate response. We stimulated whole blood triacylated lipopeptide, ligand for heterodimers, found substantial inter-individual variation sequenced...
BACKGROUND AND PURPOSE The expression of P‐glycoprotein (P‐gp), encoded by the multidrug resistance 1 (MDR1) gene, is associated with emergence MDR phenotype in cancer cells. We investigated whether metformin (1,1‐dimethylbiguanide hydrochloride) down‐regulates MDR1 MCF‐7/adriamycin (MCF‐7/adr) EXPERIMENTAL APPROACH MCF‐7 and MCF‐7/adr cells were incubated changes P‐gp determined at mRNA, protein functional level. Transient transfection assays performed to assess its gene promoter...
The transition from a chemotherapy-responsive cancer to chemotherapy-resistant one is accompanied by increased expression of multidrug resistance 1 (MDR1, <i>p</i>-glycoprotein), which plays an important role in the efflux target cell many anticancer agents. We recently showed that Forkhead box-containing protein O subfamily (FoxO1) key regulator <i>MDR1</i> gene transcription. Because nuclear localization FoxO1 regulated silent information two ortholog (SIRT1) deacetylase, we wondered...
Multidrug resistance (MDR) is a major obstacle in cancer chemotherapy and its inhibition an effective way to reverse drug resistance. In the present study, we investigated that puerarin, natural isoflavonoid from Pueraria lobata, down-regulated MDR1 expression MCF-7/adriamycin (MCF-7/adr), human breast MDR cell line. Puerarin treatment significantly inhibited expression, mRNA promoter activity MCF-7/adr cells. The suppression of was accompanied by partial recovery intracellular accumulation,...
Both type 1 and 2 diabetes are associated with increased risk of cardiovascular disease. This is in part attributed to the effects hyperglycemia on vascular endothelial smooth muscle cells, but underlying mechanisms not fully understood. In diabetic animal models, results hypercontractility possibly due activation Rho-kinase. The aim present study was investigate regulation contractile markers by glucose determine signaling pathways that activated cells. Microarray, quantitative PCR, Western...
Our previous studies have shown that multidrug resistance protein 2 (MRP2) is overexpressed in tamoxifen-resistant MCF-7 breast cancer cells (TAMR-MCF-7 cells) and forkhead box-containing protein, O subfamily1 (FoxO1), functions as a key regulator of 1 (MDR1) gene transcription. This study aimed to investigate the role FoxO1 regulating MRP2 expression TAMR-MCF-7 cells. The proximal promoter region human contains four putative FoxO binding sites, transcription was stimulated by overexpression...
The B-Raf(V599E)-mediated constitutive activation of ERK1/2 is involved in establishing the transformed phenotype some uveal melanoma cells (Calipel, A., Lefevre, G., Pouponnot, C., Mouriaux, F., Eychene, and Mascarelli, F. (2003) J. Biol. Chem. 278, 42409-42418). We have shown that stem cell factor (SCF) proliferation normal melanocytes c-Kit expressed 75% primary melanomas. This suggests acquisition autonomous growth during progression may involve SCF/c-Kit axis. used six human...
Actin dynamics in vascular smooth muscle is known to regulate contractile differentiation and may play a role the pathogenesis of disease. However, list genes regulated by actin polymerization remains incomprehensive. Thus, objective this study was identify actin-regulated demonstrate these regulation phenotype.Mouse aortic cells were treated with an actin-stabilizing agent, jasplakinolide, analyzed microarrays. Several transcripts upregulated including both previously unknown genes....
Background Diarrheagenic Escherichia coli (DEC) is a group of bacterial pathogens that causes life-threatening diarrhea in children developing countries. However, there limited information on the characteristics DEC isolated from patients these A detailed genomic analysis 61 DEC-like isolates infants with was performed to clarify and share prevalent Vietnam. Principal findings classified into 57 strains, including 33 enteroaggregative E . (EAEC) (54.1%), 20 enteropathogenic (EPEC) (32.8%),...
The H’Mong people in Si Ma Cai and Bac Ha districts, located Lao Province, Vietnam, possess a rich cultural heritage profound humanistic values. This serves as distinctive tourism resource that draws numerous visitors. Through SWOT analysis an evaluation of achievements, challenges, their underlying causes, this article presents ten solutions to strengthen preservation while promoting sustainable development. These proposed aim assist local communities authorities advancing economic,...
In order to improve the quality of mathematics education, optimise level textbook writing and promote cultural exchange between China Vietnam, this paper selects junior high school textbooks Zhejiang Education Edition in Kite Vietnam as research objects, uses comprehensive exercise difficulty model compare exercises "triangle" section from both countries. The results show that there is no significant difference overall two versions textbooks, exhibit a distribution characteristic relatively...
Abstract Identifying specific inhibitors of the MYC oncogene has been challenging, due to off target effects associated with inhibition. This study investigated how recombinant Escherichia coli Lon protease (rLon), which targets in human cells, inhibits over-activation models infection and cancer. In silico predictions identified peptide domains bacterial that affinity these peptides for was by surface plasmon resonance. The N-terminal domain rLon shown interact C-terminal, leucine zipper...
Đặt vấn đề: Trong giáo dục y khoa, việc nhận biết phong cách học tập (PCHT) giúp thiết kế chương trình, phương pháp giảng dạy hiệu quả. Mô hình VARK (Visual, Auditory, Read/Write, Kinesthetic) là công cụ phổ biến để xác định đặc điểm PCHT của sinh viên. Mục tiêu: Khảo sát viên khoa Y, Đại Y Dược Thành phố Hồ Chí Minh (2020–2021) theo mô và các yếu tố liên quan. Đối tượng nghiên cứu: Nghiên cứu cắt ngang, tả trên 709 từ năm 1 đến 6. Dữ liệu được thu thập qua bảng câu hỏi phiên bản 8.01 số...
With the aim of isolating immunomodulatory compounds from n -butanol extract Boehmeria nivea leaves, nine megastigmane were identified.