A5046054350- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Inflammatory mediators and NSAID effects
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- Estrogen and related hormone effects
- Metabolism, Diabetes, and Cancer
- Dermatology and Skin Diseases
- Bioactive Compounds and Antitumor Agents
- Cancer-related Molecular Pathways
- Carcinogens and Genotoxicity Assessment
- RNA Interference and Gene Delivery
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Allergic Rhinitis and Sensitization
- Phytochemicals and Antioxidant Activities
- Eicosanoids and Hypertension Pharmacology
- Mast cells and histamine
- Toxic Organic Pollutants Impact
- PI3K/AKT/mTOR signaling in cancer
Korea Basic Science Institute
2016-2025
Korea University of Science and Technology
2015-2025
Catholic University of Korea
2017-2024
Daejeon St. Mary's Hospital
2024
Chungnam National University
2008-2020
Cheongju University
2019-2020
Government of the Republic of Korea
2019-2020
University of Minnesota
2012-2019
Ajou University
2019
Ajou University Hospital
2019
BACKGROUND AND PURPOSE The expression of P‐glycoprotein (P‐gp), encoded by the multidrug resistance 1 (MDR1) gene, is associated with emergence MDR phenotype in cancer cells. We investigated whether metformin (1,1‐dimethylbiguanide hydrochloride) down‐regulates MDR1 MCF‐7/adriamycin (MCF‐7/adr) EXPERIMENTAL APPROACH MCF‐7 and MCF‐7/adr cells were incubated changes P‐gp determined at mRNA, protein functional level. Transient transfection assays performed to assess its gene promoter...
Synergistic immunotherapy of immune checkpoint blockade (ICB) and immunogenic cell death (ICD) has shown remarkable therapeutic efficacy in various cancers. However, patients show low response rates undesirable outcomes to these combination therapies owing the recycling mechanism programmed death-ligand 1 (PD-L1) systemic toxicity ICD-inducing chemotherapeutic drugs. Herein, we propose all-in-one glycol chitosan nanoparticles (CNPs) that can deliver anti-PD-L1 peptide (PP) doxorubicin (DOX)...
Abstract Scope: Capsaicin is a cancer‐suppressing agent. The aim of our study was to determine the effect capsaicin on tumor invasion and migration; possible mechanisms involved in this inhibition were investigated human fibrosarcoma cells. Methods results: We employed invasion, migration gelatin zymography assays characterize HT‐1080 Transient transfection immunoblot analysis performed its molecular action. inhibited epidermal growth factor (EGF)‐induced activation matrix metalloproteinase...
Background: Glioblastoma (GBM) is one of the most aggressive types brain cancer. GBM progression closely associated with microglia activation; therefore, understanding regulation crosstalk between human and may help develop effective therapeutic strategies. Elucidation efficient delivery microRNA (miRNA) via extracellular vesicles (EVs) their intracellular communications required for applications in treatment. Methods: We used cells (U373MG) microglia. MiRNA-124 was loaded into...
The overexpression of metallothionein-2A (MT-2A) is frequently observed in invasive human breast tumors and has been linked with more aggressive cancers. MT-2A led to the induction MDA-MB-231 cancer cell migratory abilities. reduction expression through small interfering RNA (siRNA) targeting cells completely inhibited both invasion migration. In addition, matrix metalloproteinase-9 (MMP-9) transcriptional activity AP-1 NF-κB were upregulated by overexpression. Collectively, our results...
Multidrug resistance (MDR) is a major obstacle in cancer chemotherapy and its inhibition an effective way to reverse drug resistance. In the present study, we investigated that puerarin, natural isoflavonoid from Pueraria lobata, down-regulated MDR1 expression MCF-7/adriamycin (MCF-7/adr), human breast MDR cell line. Puerarin treatment significantly inhibited expression, mRNA promoter activity MCF-7/adr cells. The suppression of was accompanied by partial recovery intracellular accumulation,...
Glycyl-l-histidyl-l-lysine (GHK) tripeptides are known for their remarkable therapeutic potential, including wound-healing, anti-inflammatory activity, and cellular regeneration. However, clinical application has been significantly hindered by poor biological stability limited efficacy in a physiological medium. In this study, we introduce sophisticated approach to overcome these limitations developing supramolecular peptide nanofiber-gold (Au) nanoparticle (NP) hybrids functionalized with...
Previous studies have reported that the saponins isolated from roots of Platycodon grandiflorum A. DC (Campanulaceae), Changkil (CKS), inhibited cyclooxygenase-2 (COX-2) expression in cultured lipopolysaccharide-activated macrophages. The aim this presented study was to confirm anti-inflammatory effects CKS by examining their effect on inflammatory response induced carrageenan a rat using an acute air pouch inflammation model. significantly reduced levels process markers pouch, such as...
Typically, chemopreventive agents either inhibit the cytochrome P450s (CYPs) that are essential for metabolism of carcinogens or induce phase II detoxifying enzymes. This study examined effect eugenol on 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced DNA damage in MCF‐7 cells. Eugenol inhibited formation DMBA–DNA adduct a dose dependent manner. CYP1A1 and CYP1B1 activity, which catalyze biotransformation DMBA, were strongly by eugenol. also suppressed CYP1A induction DMBA through decreased...
We report a simple and facile strategy for the preparation of multifunctional nanoparticles with programmable properties using self-assembly precisely designed block amphiphiles in an aqueous solution-state. Versatile, supramolecular nanoplatform personalized needs, particularly-theranostics, was fabricated by coassembly peptide (PAs) solution, replacing time-consuming inaccessible chemical synthesis. Fibrils, driven assembly hydrophobic β-sheet-forming block, were utilized as nanotemplate...
A self-assembled amphiphilic fluorescent probe allows pH-fluctuations within cancer cells and tumour tissues to be readily detected.