A5028371225- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Health and Wellbeing Research
- Diverse Approaches in Healthcare and Education Studies
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Advanced biosensing and bioanalysis techniques
- Advanced Proteomics Techniques and Applications
- Angiogenesis and VEGF in Cancer
- 3D Printing in Biomedical Research
- Erythrocyte Function and Pathophysiology
- Pluripotent Stem Cells Research
- Virus-based gene therapy research
- Ovarian cancer diagnosis and treatment
- Burn Injury Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Protease and Inhibitor Mechanisms
- Network Security and Intrusion Detection
- Pituitary Gland Disorders and Treatments
- Telecommunications and Broadcasting Technologies
- IPv6, Mobility, Handover, Networks, Security
Ewha Womans University
2023-2024
Korea Institute of Science and Technology
2019-2022
Korea University
2020-2022
Abstract Macrophages (Mφs) are characterized by remarkable plasticity, an essential component of chronic inflammation. Thus, appropriate and timely transition from proinflammatory (M1) to anti‐inflammatory (M2) Mφs during wound healing is vital promoting resolution acute inflammation enhancing tissue repair. Herein, exosomes derived M2‐Mφs (M2‐Exos), which contain putative key regulators driving Mφ polarization, used as local microenvironmental cues induce reprogramming M1‐Mφs toward for...
Exosomes are cellular components with promising uses in cancer diagnostics and therapeutics, their imaging tracking essential to study biological properties. Herein, we report on an situ one-step fluorescence labeling strategy for exosomes via bioorthogonal click chemistry. First, exosome donor cells were treated tetraacetylated N-azidoacetyl-d-mannosamine (Ac4ManNAz) generate unnatural azide groups (−N3) surface metabolic glycoengineering. Then, the labeled near-infrared fluorescent...
Synergistic immunotherapy of immune checkpoint blockade (ICB) and immunogenic cell death (ICD) has shown remarkable therapeutic efficacy in various cancers. However, patients show low response rates undesirable outcomes to these combination therapies owing the recycling mechanism programmed death-ligand 1 (PD-L1) systemic toxicity ICD-inducing chemotherapeutic drugs. Herein, we propose all-in-one glycol chitosan nanoparticles (CNPs) that can deliver anti-PD-L1 peptide (PP) doxorubicin (DOX)...
Noninvasive and precise stem cell tracking after transplantation in living subject is very important to monitor both destinations their vivo fate, which closely related therapeutic efficacy. Herein, we developed bicyclo[6.1.0]nonyne (BCN)-conjugated glycol chitosan nanoparticles (BCN-NPs) as a delivery system of dual-modal imaging probes. Near-infrared fluorescent (NIRF) dye Cy5.5 was chemically conjugated the BCN-NPs, then oleic acid-coated superparamagnetic iron oxide (OA-Fe3O4 NPs) were...
Prodrugs are bioreversible medications that should undergo an enzymatic or chemical transformation in the tumor microenvironment to release active drugs, which improve cancer selectivity reduce toxicities of anticancer drugs. However, such approaches have been challenged by poor therapeutic efficacy attributed a short half-life and low targeting. Herein, we propose cathepsin B-overexpressed cell activatable albumin-binding doxorubicin prodrug, Al-ProD, consists maleimide group, B-cleavable...
Immune checkpoint blockade (ICB) therapy targeting PD-L1 via monoclonal antibody (mAb) has shown extensive clinical benefits in the diverse types of advanced malignancies. However, most patients are completely refractory to ICB owing recycling mechanism. Herein, we propose photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes (immune liposomes; ICB-LPs) promote multivalent binding for inducing lysosomal degradation tumor cells. The ICB-LPs prepared by formulation DC8,9PC...
Photothermal therapy (PTT) at mild temperatures ranging from 44 to 45 °C holds tremendous promise as a strategy for inducing potent immunogenic cell death (ICD) within tumor tissues, which can reverse the immunosuppressive microenvironment (ITM) into an immune-responsive milieu. However, accurately and precisely controlling temperature remains formidable challenge. Here, we report precision photothermal immunotherapy by using silica-coated gold nanorods (AuNR@SiO 2 ), investigating optimal...
A prodrug is bioreversible medication that specifically converted to the active drugs by enzymes overexpressed in tumor microenvironment, which can considerably reduce chemotherapy-induced side effects. However, strategies usually have low antitumor efficacy compared free delayed drug release. This because they need time be activated enzymatic cleavage and also cannot fully recovered drugs. Therefore, highly potent anticancer should considered expect a sufficient efficacy. Herein, we propose...
Nanoparticles have been used for effectively delivering imaging agents and therapeutic drugs into stem cells. However, nanoparticles are not sufficiently internalized cells; thus, new delivery method of cells is urgently needed. Herein, we develop bicyclo[6.1.0]nonyne (BCN)-conjugated gold (BCN-AuNPs), which can be bioorthogonally conjugated to azide (−N3) groups on the surface metabolically engineered via bioorthogonal click chemistry. For incorporating cell surface, first, human...
A series of successes in RNA interference (RNAi) therapies for liver diseases using lipid nanoparticles and N-acetylgalactosamine have heralded a current era therapeutics. However, alternative delivery strategies are required to take RNAi out the comfort zone hepatocytes. Here we report SIRPα IgV/anti-CD47 siRNA (vS-siCD47) conjugates that selectively persistently disrupt antiphagocytic CD47/SIRPα axis solid tumors. Conjugation IgV domain protein siRNAs enables tumor dash through...
Proteolysis‐targeting chimeras (PROTACs) are a promising technique for the specific and durable degradation of cancer‐related proteins via ubiquitin‐proteasome system in cancer treatment. However, therapeutic efficacy PROTACs is restricted due to their hydrophobicity, poor cell permeability insufficient tumor‐targeting ability. Herein, we develop self‐assembled peptide‐derived PROTAC nanoparticles (PT‐NPs) precise programmed death‐ligand 1 (PD‐L1) targeted tumors. The PT‐NPs with an average...
Proteolysis-targeting chimeras (PROTACs) are a promising technique for the specific and durable degradation of cancer-related proteins via ubiquitin-proteasome system in cancer treatment. However, therapeutic efficacy PROTACs is restricted due to their hydrophobicity, poor cell permeability insufficient tumor-targeting ability. Herein, we develop self-assembled peptide-derived PROTAC nanoparticles (PT-NPs) precise programmed death-ligand 1 (PD-L1) targeted tumors. The PT-NPs with an average...
Gold nanoparticles (AuNPs) with various sizes and morphologies have been extensively investigated for effective photothermal therapy (PTT) against multiple cancer types. However, a highly dynamic complex tumor microenvironment (TME) considerably reduces the efficacy of PTT by limiting deep penetration AuNPs. Herein, we propose mesenchymal stem cell (MSC)-mediated delivery gold nanorod (AuNR) potent PTT. First, MSCs are treated tetraacylated N-azidomannosamine (Ac4ManNAz) to introduce...
<b><i>Objective:</i></b> We performed this prospective study to identify both the incidence of adrenal insufficiency (AI) and health-related quality life (HRQOL) in advanced gastric cancer (AGC) patients who were treated with S-1 plus cisplatin (SP) regimen as a first-line palliative chemotherapy. <b><i>Methods:</i></b> assessed adverse events (AEs) observed 52 received SP for AGC between January 2009 June 2010 using Common Toxicity Criteria...
The purpose of this study is to investigate factors affecting cancer mortality inequality in Busan according demographic characteristics identified based on the region`s data including incidence and rates, ultimately helping region improve its existing health policies establish a more effective prevention policy. To achieve purpose, researcher surveyed about all persons who died from 2006 2009. Data were analyzed with an SPSS 18.0 program using descriptive statistics, Chi-Square(), Logistic...
공공와이파이를 이용한 메일확인과 인터넷뱅킹 등의 네트워크 통신량이 증가함에 따라 공공공유기 해킹의 위험성이 지속적으로 높아지고 있다. 국가적으로 공공공유기를 확대하는데 비해 사용자의 보안인식은 부족하여 개인정보 노출 커지고 무선공유기는 접근성이 뛰어나지만 상대적으로 해킹이 용이하므로 대응차원의 해킹에 대한 분석이 중요하다. 본 논문에서는 와이파이에 사용되는 암호화 방식 및 무선공유기의 보안 공격에 무료와이파이 해킹 사례분석 해결방안을 제안한다. As network communication increases by using public WiFi to check e-mail and handling Internet banking, the danger of hacking routers continues rise. While national policy is further propagate routers, users are not eager keep their information...
Objectives : The aim of this study is to suggest a direction for sexual education suitable the aged by analyzing senior citizens' perception level and demand among elderly, such as their feelings on necessity patterns sex education. Methods population survey targeted elderly residents over 60 who are taking lectures at 4 university lifelong centers that located in Busan. period data collection was from May 10, 2013 30, 2013. methods were frequency analysis, t-test, correlation analysis....