A5101845110- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Peptidase Inhibition and Analysis
- Photoacoustic and Ultrasonic Imaging
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Protease and Inhibitor Mechanisms
Korea University
2020-2024
Ewha Womans University
2024
Korea Institute of Science and Technology
2020-2022
Immune checkpoint blockade is a promising approach for cancer immunotherapy, but many patients do not respond due to the immunosuppressive tumor microenvironment (ITM). Herein, we propose visible-light-triggered prodrug nanoparticles (LT-NPs) reversing ITM into high immunogenic tumors potentiate immunotherapy. The photosensitizer (verteporfin; VPF), cathepin B-specific cleavable peptide (FRRG), and doxorubicin (DOX) conjugates are self-assembled LT-NPs without any additional carrier...
Direct local delivery of immunogenic cell death (ICD) inducers to a tumor site is an attractive approach for leading ICD effectively, due enabling the concentrated site. Herein, we prepared doxorubicin (DOX)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) using different molecular weight PLGA (7000 g/mol and 12,000 g/mol), showing drug release kinetics. The kinetics DOX might differently stimulate cell-specific immune response by releasing damage-associated patterns (DAMPs),...
Immunogenic cell death (ICD) is a crucial approach to turn immunosuppressive tumor microenvironment (ITM) into immune-responsive milieu and improve the response rate of immune checkpoint blockade (ICB) therapy. However, cancer cells show resistance ICD-inducing chemotherapeutic drugs, non-specific toxicity those drugs against reduce immunotherapy efficiency.
Immunogenic cell death (ICD) is a powerful trigger eliciting strong immune responses against tumors. However, traditional chemoimmunotherapy (CIT) does not last long enough to induce sufficient ICD, and also guarantee the safety of chemotherapeutics. To overcome disadvantages conventional approach, we used doxorubicin (DOX) as an ICD inducer, poly(lactic-co-glycolic acid) (PLGA)-based nanomedicine platform for controlled release DOX. The diameter 138.7 nm DOX-loaded PLGA nanoparticles...
Photodynamic therapy (PDT) is a promising strategy to promote antitumor immunity by inducing immunogenic cell death (ICD) in tumor cells. However, practical PDT uses an intense visible light owing the shallow penetration depth of light, resulting immunosuppression at tissues.Herein, we propose implantable micro-scale light-emitting diode device (micro-LED) guided that enables on-demand activation photosensitizers deep body potentiate with mild light.The micro-LED prepared stacking one four...
Abstract Photodynamic therapy shows promise for glioma treatment with powerful efficacy and low resistance, however, its effectiveness is significantly lowered by inadequate light delivery through the skull. Herein, a needle‐type implantable microLED device cathepsin B‐responsive prodrug nanoparticles (PNPs) are newly exploited glioma's chemo‐photodynamic combination therapy. The containing four small LEDs on tip of guide needle can be implanted into center tissues without large area opening...
Glioma is a highly lethal tumor with poor prognosis, in which the presence of blood-brain barrier (BBB) and skull significantly limits treatment options. To address this, tumor-implantable optofluidic system (LED-SC), consisting microsized LED (microLED) microsyringe chip (SC), proposed to deliver both light prodrug nanoparticles (PNPs) directly brain glioma. The LED-SC combines microLED SC enable intratumoral administration PNPs for chemophotodynamic therapy. PNPs, self-assembled...
Photothermal therapy (PTT) at mild temperatures ranging from 44 to 45 °C holds tremendous promise as a strategy for inducing potent immunogenic cell death (ICD) within tumor tissues, which can reverse the immunosuppressive microenvironment (ITM) into an immune-responsive milieu. However, accurately and precisely controlling temperature remains formidable challenge. Here, we report precision photothermal immunotherapy by using silica-coated gold nanorods (AuNR@SiO 2 ), investigating optimal...
A prodrug is bioreversible medication that specifically converted to the active drugs by enzymes overexpressed in tumor microenvironment, which can considerably reduce chemotherapy-induced side effects. However, strategies usually have low antitumor efficacy compared free delayed drug release. This because they need time be activated enzymatic cleavage and also cannot fully recovered drugs. Therefore, highly potent anticancer should considered expect a sufficient efficacy. Herein, we propose...