A5089845069- Bone health and treatments
- Bone Metabolism and Diseases
- Advanced Breast Cancer Therapies
- Chronic Lymphocytic Leukemia Research
- Cancer-related Molecular Pathways
- Thyroid Cancer Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Management of metastatic bone disease
- Lung Cancer Treatments and Mutations
- Stroke Rehabilitation and Recovery
- Genetic factors in colorectal cancer
- Neurobiology and Insect Physiology Research
- Silk-based biomaterials and applications
- Cancer Research and Treatments
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Musculoskeletal pain and rehabilitation
- Protein Degradation and Inhibitors
- Pancreatic and Hepatic Oncology Research
- Nutrition, Genetics, and Disease
- Estrogen and related hormone effects
- Liver physiology and pathology
- Developmental Biology and Gene Regulation
- Botulinum Toxin and Related Neurological Disorders
Leiden University
2025
Lund University
2025
Institute for Molecular Medicine
2024
University of Lisbon
2019-2023
Instituto de Medicina Molecular João Lobo Antunes
2022
Regeneration is the replacement of lost or damaged tissue with a functional copy. In axolotls and zebrafish, regeneration involves stem cells produced by de-differentiation. These form growth zone which expresses developmental patterning genes at its apex. This system resembles an embryonic field where undergo pattern formation. Some lizards, including geckos, can regenerate their tails, but it unclear whether they show "development-like" pathway. Using tokay gecko (Gekko gecko) model...
Abstract Identifying specific inhibitors of the MYC oncogene has been challenging, due to off target effects associated with inhibition. This study investigated how recombinant Escherichia coli Lon protease (rLon), which targets in human cells, inhibits over-activation models infection and cancer. In silico predictions identified peptide domains bacterial that affinity these peptides for was by surface plasmon resonance. The N-terminal domain rLon shown interact C-terminal, leucine zipper...
The combination of endocrine therapy (ET) and cyclin-dependent kinase 4/6 (CDK4/6) inhibitors (CDK4/6i) was a hallmark in metastatic luminal breast cancer (BC). However, intrinsic acquired resistance affects long-term efficacy. Here, we study the role receptor activator nuclear factor-κB (RANK) pathway CDK4/6i resistance. We find that RANK overexpression BC is associated with to CDK4/6i, both vitro mouse xenografts, decreased proliferation rate chronic interferon (IFN) γ response are...
// Inês Gomes 1 , Bernardo P. de Almeida 2 4 Sara Dâmaso 3 André Mansinho Correia Henriques Raquel Cruz-Duarte Guilherme Vilhais Pedro Félix Patrícia Alves Corredeira Nuno L. Barbosa-Morais Luis Costa and Sandra Casimiro Laboratory, Instituto Medicina Molecular, Faculdade da Universidade Lisboa, Portugal Morais Serviço Oncologia, Hospital Santa Maria-CHULN, Current affiliation: Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria Correspondence to:...
Background: The molecular basis of familial nonmedullary thyroid cancer (FNMTC) is still poorly understood, representing a limitation for diagnosis and clinical management. In this study, we aimed to identify new susceptibility genes FNMTC through whole-exome sequencing (WES) analysis leukocyte DNA patients from highly informative family. Methods: We selected six affected family members conduct WES analysis. Bioinformatic analyses were undertaken filter select the genetic variants shared by...
<title>Abstract</title> Despite chemotherapy's limitations and toxic effects, it remains the primary treatment for most triple-negative breast cancer (TNBC) patients. While cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy have revolutionized luminal treatment, CDK4/6i alone are largely ineffective in TNBC, even functional retinoblastoma protein (pRB). The receptor activator of nuclear factor-κB (RANK) pathway has been linked to poor prognosis TNBC. Previous...
Virtual Reality (VR) has finally found its way to be used in the healthcare industry, covering many different areas such as medical training, marketing, patient education, psychotherapy and physiotherapy, others. The need develop increasingly personalized technology during rehabilitation process is extremely important. Therefore, VR4NeuroPain solution aims cover unique influence that it obtains from VR applied area, creating virtual spaces where patients with neuropathic pain can submitted...
Background: The receptor activator of NFkB (RANK)-RANK ligand (RANKL) pathway, pivotal regulator bone remodeling, has emerged as a major mediator progesterone-driven breast cancer (BC) carcinogenesis. RANK expression is particularly elevated in triple negative BC and been associated with aggressiveness poor prognosis. This study addressed the impact estrogen (ER)-positive BC. Methods: In silico analysis (TNFRSF11A) was performed TCGA cohort. ER+HER2- cell lines overexpressing were obtained...