A5101826547- Peptidase Inhibition and Analysis
- Digestive system and related health
- Chemical Reactions and Isotopes
- Cancer Research and Treatments
- Hydrogen's biological and therapeutic effects
- Protein Degradation and Inhibitors
Lund University
2024-2025
Abstract Identifying specific inhibitors of the MYC oncogene has been challenging, due to off target effects associated with inhibition. This study investigated how recombinant Escherichia coli Lon protease (rLon), which targets in human cells, inhibits over-activation models infection and cancer. In silico predictions identified peptide domains bacterial that affinity these peptides for was by surface plasmon resonance. The N-terminal domain rLon shown interact C-terminal, leucine zipper...
Though new targeted therapies for colorectal cancer, which progresses from local intestinal tumors to metastatic disease, are being developed, tumor specificity remains an important problem, and side effects a major concern. Here, we show that the protein-fatty acid complex BAMLET (bovine alpha-lactalbumin made lethal cells) can act as peroral treatment cancer. ApcMin/+ mice, carry mutations relevant hereditary sporadic human received in drinking water showed long-term protection against...