A5020765041- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Influenza Virus Research Studies
- Toxin Mechanisms and Immunotoxins
- Phytochemical compounds biological activities
- Plant chemical constituents analysis
- Animal Virus Infections Studies
- Natural Antidiabetic Agents Studies
- Sirtuins and Resveratrol in Medicine
- Phytochemistry and Bioactive Compounds
- Bioactive natural compounds
- Herpesvirus Infections and Treatments
- Biochemical and Structural Characterization
- Medicinal Plants and Neuroprotection
- Carbohydrate Chemistry and Synthesis
- RNA and protein synthesis mechanisms
- Metabolism, Diabetes, and Cancer
- Genomics, phytochemicals, and oxidative stress
- Herbal Medicine Research Studies
- Synthesis of Organic Compounds
- Liver Disease Diagnosis and Treatment
- Bioactive Compounds and Antitumor Agents
Can Tho University
2020-2024
National Institute of Nutrition
2024
Seoul National University
1997-2020
Duksung Women's University
1997
New metabolites, xiamycins C–E (1–3), were isolated from a Streptomyces. sp (#HK18) culture inhabiting the topsoil in Korean solar saltern. The planar structures of elucidated as carbazole-bearing indolosesquiterpenoids using combined analysis NMR, MS, UV, and IR spectroscopic data. absolute configurations these new compounds determined by analyses NOESY ECD When tested for inhibitory activity on porcine epidemic diarrhea virus (PEDV), xiamycin D (2) showed strongest effect PEDV replication...
Porcine epidemic diarrhea virus (PEDV) infections have resulted in a severe economic loss the swine industry many countries due to no effective treatment approach. Fifteen oleanane triterpenes (1-15), including nine new ones (1-4 and 10-14), were isolated from flowers of Camellia japonica, their molecular structures determined by extensive spectroscopic methods. These compounds evaluated for antiviral activity against PEDV replication, structure-activity relationships (SARs) discussed....
Ecklonia cava is edible seaweed that found in Asian countries, such as Japan and Korea; and, its major components include fucoidan phlorotannins. Phlorotannins are isolated from E. well-known to have an antioxidant effect strong antiviral activity against porcine epidemic diarrhea virus (PEDV), which has a high mortality rate piglets. In this study, the bioactive were determined based on two different approaches: (i) bio-guided isolation using H1N1 viral strain, representative influenza...
Abstract Chitosan (CS), which is extracted from insects, especially black soldier fly (BSF) ( Hermetia illucens ), currently considered a latent source. The present work chitin and CS using chemical method the two life stages of BSF, including dead cocoon. initial materials were deproteinized with 5% NaOH, demineralized 4% HCl, decolorized 1% KMNO 4 to obtain chitin. obtained was deacetylated 70% NaOH gain CS. yield (%) 9.72 - 37.03%, BSF cocoons having highest yield. isolated then...
To determine the compounds responsible for its anti-influenza activities, we isolated three flavonoids, 6-hydroxyluteolin 7-O-β-d-glucoside (1), nepitrin (2), homoplantaginin (3) from MeOH extract of Salvia plebeia R.Br. and identified them by comparing spectroscopic data with that reported in literature. The contents flavonoids whole were 108.74 ± 0.95, 46.26 2.19, 69.35 1.22 mg/g 7-O-β-d-glucoside, nepitrin, homoplantaginin, respectively, which demonstrates they are major constituents this...
Pinus densiflora was screened in an ongoing project to discover anti-influenza candidates from natural products. An extensive phytochemical investigation provided 26 compounds, including two new megastigmane glycosides (1 and 2), 21 diterpenoids (3-23), three flavonoids (24-26). The chemical structures were elucidated by a series of reactions, modified Mosher's analysis various spectroscopic measurements such as LC/MS 1D- 2D-NMR. A activities all isolates cytopathic effect (CPE) inhibition...
PTP1B deficiency in mouse mammary tumor virus (MMTV)-NeuNT transgenic mice inhibited the onset of MMTV-NeuNT-evoked breast cancer, while its overexpression was observed cancer. Thus, inhibitors are considered chemopreventative agents for As part our program to find inhibitors, one new diterpene glycoside (1) and 13 known compounds (2-14) were isolated from methanol extract stems Akebia quinata. All isolates identified based on extensive spectroscopic data analysis, including UV, IR, NMR MS....
A phytochemical investigation of the flowers Chrysanthemum indicum yielded sesquiterpenoids 1–25 with various carbocyclic skeletons, including 10 new (1–10) and 15 known (11–25) analogues. The structures were elucidated via their physical data, while absolute configuration compounds 6, 8, was assessed electronic circular dichroism analysis. evaluation effect on porcine epidemic diarrhea virus (PEDV) replication showed that 1–5, 12, 14, 16, 17, 19, 21 increased cell viability against death in...
During a search for SIRT1 activators originating in nature, three new dammarane triterpenes, 6α,20(S)-dihydroxydammar-3,12-dione-24-ene (1), 6α,20(S),24(S)-trihydroxydammar-3,12-dione-25-ene (2), and 6α,20(S),25-trihydroxydammar-3,12-dione-23-ene (3), as well two known dammar-20(22),24-diene-3β,6α,12β-triol (4) 20(S)-ginsenoside Rg3 (5), were isolated from Panax ginseng leaves. Compounds 1 3–5 showed potential activators, analyzed by vitro enzyme-based SIRT1-NAD/NADH SIRT1-p53 luciferase...
Thirteen C-methylated flavonoid glycosides (1–13), along with 15 previously known flavonoids (14–28), were isolated from rhizomes of Pentarhizidium orientale. Among these compounds, matteuorienates D–K (1–8) obtained as analogues A–C (14–16), which contain a characteristic 3-hydroxy-3-methylglutaryl (HMG) moiety. The structures 1–13 characterized by spectroscopic analysis and chemical derivatization. isolates evaluated for their antiviral activities against influenza virus (H1N1), compounds...