A5045827347- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Synthetic Organic Chemistry Methods
- Synthesis and Biological Activity
- Biochemical and Structural Characterization
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Coral and Marine Ecosystems Studies
- Seaweed-derived Bioactive Compounds
- Chemical synthesis and alkaloids
- Fungal Biology and Applications
- Crustacean biology and ecology
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Analysis
- Antifungal resistance and susceptibility
- Genomics and Phylogenetic Studies
- Carbohydrate Chemistry and Synthesis
- Plant biochemistry and biosynthesis
- Phytochemical compounds biological activities
- Advanced Synthetic Organic Chemistry
- Botanical Research and Chemistry
- Cholinesterase and Neurodegenerative Diseases
- Insect symbiosis and bacterial influences
- Angiogenesis and VEGF in Cancer
- Marine Biology and Environmental Chemistry
Seoul National University
2015-2024
Kolon Life Science (South Korea)
2016-2022
Hanyang University
2019
National Academy of Agricultural Science
2012
Hannam University
2001-2010
Yeungnam University
2010
Korea Institute of Ocean Science and Technology
1997-2009
Hanbat National University
2005-2008
Korea Maritime and Ocean University
2004-2008
Daegu Fatima Hospital
2008
Abstract Sanshools are major active ingredients of Zanthoxylum piperitum and used as food additives in East Asia. cause irritant, tingling sometimes paresthetic sensations on the tongue. However, molecular mechanism underlying pungent or sensation induced by sanshools is not known. Because many transient receptor potential (TRP) channels responsible for various spices additives, we expressed 17 TRP human embryonic kidney (HEK) cells investigated their activation hydroxy‐α‐sanshool (HαSS)...
Ohmyungsamycins A and B (1 2), which are new cyclic peptides, were isolated from a marine bacterial strain belonging to the Streptomyces genus collected sand beach on Jeju, volcanic island in Republic of Korea. Based interpretation NMR, UV, IR spectroscopic MS data, planar structures 1 2 elucidated as depsipeptides bearing unusual amino acid units, including N-methyl-4-methoxytrytophan, β-hydroxyphenylalanine, N,N-dimethylvaline. The absolute configurations α-carbons residues determined...
Sungsanpin (1), a new 15-amino-acid peptide, was discovered from Streptomyces species isolated deep-sea sediment collected off Jeju Island, Korea. The planar structure of 1 determined by 1D and 2D NMR spectroscopy, mass spectrometry, UV spectroscopy. absolute configurations the stereocenters in this compound were assigned derivatizations hydrolysate with Marfey's reagents 2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl isothiocyanate, followed LC-MS analysis. Careful analysis ROESY spectrum...
Mohangamides A and B (1–2) were discovered from a marine Streptomyces sp. collected in an intertidal mud flat. The structures of the compounds elucidated as novel dilactone-tethered pseudodimeric peptides bearing two unusual acyl chains 14 amino acid residues based on comprehensive spectroscopic analysis. absolute configurations mohangamides determined by chemical derivatizations, followed chromatographic analyses. Mohangamide displayed strong inhibitory activity against Candida albicans...
Sargachromanols A−P (1−16), sixteen new meroterpenoids of the chromene class, were isolated from brown alga Sargassum siliquastrum collected Jaeju Island, Korea. On basis combined results spectral and chemical analyses, structures polyprenyl portions these chromanol-containing compounds determined to be linear triprenyls (1 2) tetraprenyls (3−11), while others corresponding rearranged (12−15) cyclized (16) tetraprenyls, respectively. The exhibited significant antioxidant activity in DPPH...
Bis(indole) alkaloids, of the topsentin class (1—4) and hamacanthin (5—9), isolated from marine sponge Spongosorites sp. were investigated using several biological assays. In evaluation antimicrobial activity against various strains bacteria fungi, compounds exhibited more potent antibacterial than those class. Deoxytopsentin (1) A (5) also significant methicillin-resistant Staphylococcus aureus, with MIC values less 12.5 μg/ml. antifungal test, hamacanthins, especially (5), showed...
Abstract During the search for anticholinesterase compounds from marine organisms, two known plastoquinones, sargaquinoic acid (1) and sargachromenol (2), were isolated Sargassum sagamianum . Both showed moderate acetylcholinesterase (AChE) inhibitory activity in a micromole range (IC 50 23.2 32.7 µ m , respectively). However, butyrylcholinesterase (BuChE), new target treatment of Alzheimer's disease (AD), compound 1 particularly potent 26 n ), which is 1000‐fold greater than AChE. Hence,...
Twenty-four metabolites, including seven new compounds (1–7), were isolated from the dried fruits of Psoralea corylifolia. On basis combined spectroscopic and chemical analysis, determined to be six flavonoids (1–6) a meroterpenoid (7). The absolute configurations natural products obtained, previously undetermined 16 17, assigned by several methods, such as NOE spectroscopy, optical rotation, CD spectroscopy. Several these exhibited moderate inhibitory activity toward Staphylococcus...
New metabolites, xiamycins C–E (1–3), were isolated from a Streptomyces. sp (#HK18) culture inhabiting the topsoil in Korean solar saltern. The planar structures of elucidated as carbazole-bearing indolosesquiterpenoids using combined analysis NMR, MS, UV, and IR spectroscopic data. absolute configurations these new compounds determined by analyses NOESY ECD When tested for inhibitory activity on porcine epidemic diarrhea virus (PEDV), xiamycin D (2) showed strongest effect PEDV replication...
Bahamaolides A and B (1 2), two new 36-membered macrocyclic lactones, were isolated from the culture of marine actinomycete Streptomyces sp. derived a sediment sample collected at North Cat Cay in Bahamas. The planar structures 1 2, bearing hexaenone nine consecutive skipped hydroxy groups, determined by 1D 2D NMR, mass, IR, UV spectra. absolute configurations bahamaolides established combined multistep chemical reactions spectroscopic analysis. Bahamaolide displayed significant inhibitory...
Two new cyclic peptides (2 and 3) along with the previously reported nocardamine (1) were isolated from culture broth of an actinomycete genus Streptomyces unidentified marine sponge. On basis results combined spectral analyses, structures compounds defined to be dehydroxy desmethylenyl derivatives nocardamine, respectively. The exhibited weak inhibition against enzyme sortase B.
Histone deacetylase (HDAC) has been highlighted as one of key players in tumorigenesis and angiogenesis. Recently, several derivatives psammaplin (Psams) from a marine sponge have known to inhibit the HDAC activity, but molecular mechanism for inhibition not fully understood. Here, we explored mode action Psams activity cellular level. Among derivatives, A (Psam A) showed potent inhibitory enzyme assay anti-proliferation with IC50 value 0.003 1 µM, respectively. Psam selectively induced...
Magnaporthe grisea is a fungal pathogen of rice that forms appressoria penetrate the outer cuticle plant. Data from recent studies indicate M. isocitrate lyase (ICL), key enzyme in glyoxylate cycle, highly expressed during appressorium-mediated plant infection. Bromophenols isolated red alga Odonthalia corymbifera exhibited potent ICL inhibitory activity and blocked formation by concentration-dependent manner. In addition, these compounds protected plants infection grisea. Rice infected with...
Two new pyrroloiminoquinone alkaloids of the discorhabdin class, along with 12 compounds including one previously described synthetic derivative same and related skeletal classes, were isolated from sponge Sceptrella sp., collected Gageodo, Korea. The structures these compounds, designated as (-)-3-dihydrodiscorhabdin D (11) (-)-discorhabdin Z (12), determined by combined spectroscopic analyses. Compound possesses an unusual hemiaminal group among alkaloids. These exhibited moderate to...