A5035038702- Redox biology and oxidative stress
- Bone Metabolism and Diseases
- Bone health and treatments
- Oral microbiology and periodontitis research
- Heat shock proteins research
- Advanced Data Storage Technologies
- Glutathione Transferases and Polymorphisms
- Animal Genetics and Reproduction
- Diverse Approaches in Healthcare and Education Studies
- interferon and immune responses
- Pluripotent Stem Cells Research
- Caching and Content Delivery
- Education, Safety, and Science Studies
- Genomics, phytochemicals, and oxidative stress
- Education and Learning Interventions
- Cytokine Signaling Pathways and Interactions
- Sulfur Compounds in Biology
- Advanced Memory and Neural Computing
- Aquaculture Nutrition and Growth
- Phase-change materials and chalcogenides
- Retinoids in leukemia and cellular processes
- RNA Interference and Gene Delivery
- Microbial Natural Products and Biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Aquaculture disease management and microbiota
Kyungpook National University
2010-2025
Yonsei University
2009-2025
Seoul National University Hospital
2023-2025
Chonnam National University
2015-2024
Gyeongsang National University
2022-2024
University of Cambridge
2014-2024
Pukyong National University
2024
Chonnam National University Hospital
2024
Kyung Hee University
2011-2023
Health Insurance Review and Assessment Service
2021-2023
Smart textiles consist of discrete devices fabricated from-or incorporated onto-fibres. Despite the tremendous progress in smart for lighting/display applications, a large scale approach display system with integrated multifunctional traditional textile platforms has yet to be demonstrated. Here we report realisation fully operational 46-inch consisting RGB fibrous LEDs coupled fibre that are capable wireless power transmission, touch sensing, photodetection, environmental/biosignal...
Peroxiredoxins (Prxs) play an important role in regulating cellular differentiation and proliferation several types of mammalian cells. One mechanism for this action involves modulation hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-mediated responses. This report examines the expression Prx I II thyroid cells their roles eliminating H<sub>2</sub>O<sub>2</sub> produced response to thyrotropin (TSH). are constitutively expressed FRTL-5 expression, but not is stimulated by exposure TSH...
Abstract Purpose Hippocampal injury from WBRT contributes to neurocognitive decline in brain malignancy patients. HA-WBRT may mitigate this by reducing hippocampal radiation exposure, but its feasibility PCNSL remains unassessed regarding involvement and failure rates. This study evaluates at diagnosis after treatment Materials methods We conducted a retrospective analysis of 278 immunocompetent patients diagnosed between 2000 2021. Following high-dose methotrexate-based induction...
Mammalian 2-Cys peroxiredoxin II (Prx II) is a cellular peroxidase that eliminates endogenous H(2)O(2). The involvement of Prx in the regulation lipopolysaccharide (LPS) signaling poorly understood. In this report, we show LPS induces substantially enhanced inflammatory events, which include molecules nuclear factor kappaB and mitogen-activated protein kinase (MAPK), II-deficient macrophages. This effect was mediated by robust up-regulation reactive oxygen species (ROS)-generating...
This study evaluated the chemical composition, antioxidant, anti-inflammatory and anticancer activities of a Euphorbia hirta L. extract. The antioxidant whole E. ethanol extract were determined by electron spin resonance spectrophotometric analysis 1,1-diphenyl-2-picryl-hydrazyl (DPPH), hydroxyl, alkyl radical levels using an online high-performance liquid chromatography (HPLC)-2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assay. (0.5 mg/mL) exhibited DPPH-scavenging activity 61.19%...
Abstract Macrophages release iron into the bloodstream via a membrane-bound export protein, ferroportin (FPN). The hepatic iron-regulatory hormone hepcidin controls FPN internalization and degradation in response to bacterial infection. Salmonella typhimurium can invade macrophages proliferate -containing vacuole (SCV). Hepcidin is reported increase mortality of -infected animals by increasing load macrophages. Here we assess levels find that increases content cytosol but decreases it SCV...
Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. In Staphylococcus aureus, deletion sortase isoforms results in marked reduction and infection potential, making it an important antivirulence target. We examined effects naturally occurring flavonols on recombinant A (SrtA) B (SrtB) prepared from S. aureus ATCC6538p found that these compounds inhibited activity sortases, without exhibiting...
Bis(indole) alkaloids, of the topsentin class (1—4) and hamacanthin (5—9), isolated from marine sponge Spongosorites sp. were investigated using several biological assays. In evaluation antimicrobial activity against various strains bacteria fungi, compounds exhibited more potent antibacterial than those class. Deoxytopsentin (1) A (5) also significant methicillin-resistant Staphylococcus aureus, with MIC values less 12.5 μg/ml. antifungal test, hamacanthins, especially (5), showed...
Significance The ever-increasing demand for faster computers is tackled by reducing the size of devices, but this becoming almost impossible to continue. To improve speed computers, a solution increase number operations performed per device. Numerous in phase-change–based “in-memory” logic devices have previously been achieved using crystallization, they show slow speeds, mostly due trade-off between crystallization and stability initialized-glassy states. Here, we instead control melting...
Tumor necrosis factor-α (TNF-α) induces the activation of all three types mitogen-activated protein kinase (MAPK): c-Jun NH2-terminal (JNK), p38, and extracellular signal-regulated (ERK). This cytokine also production several reactive oxygen species, including H2O2. With use both HeLa cells expressing wild-type or dominant negative forms cytosolic peroxidase peroxiredoxin II mouse embryonic fibroblasts deficient in this protein, we evaluated roles H2O2 MAPKs by TNF-α. In vitro assays as well...
Carbonic anhydrase III is a cytosolic protein which particularly abundant in skeletal muscle, adipocytes, and liver. The specific activity of this isozyme quite low, suggesting that its physiological function not hydrating carbon dioxide. To understand the cellular roles carbonic III, we inactivated Car3 gene. Mice lacking were viable fertile had normal life spans. has also been implicated response to oxidative stress. We found mice same hyperoxic challenge as did their wild-type siblings....
Magnaporthe grisea is a fungal pathogen of rice that forms appressoria penetrate the outer cuticle plant. Data from recent studies indicate M. isocitrate lyase (ICL), key enzyme in glyoxylate cycle, highly expressed during appressorium-mediated plant infection. Bromophenols isolated red alga Odonthalia corymbifera exhibited potent ICL inhibitory activity and blocked formation by concentration-dependent manner. In addition, these compounds protected plants infection grisea. Rice infected with...
Objectives The in vivo efficacy of a cefotaxime-ciprofloxacin combination against Vibrio vulnificus and the effects on rtxA1 expression commonly used antibiotics are unknown. Methods In vitro time-kill studies were performed to evaluate synergism. Female BALB/c mice injected subcutaneously with 1×107 or 1×108 cfu V. vulnificus. Antibiotic therapy was initiated at 2 h after inoculation following four groups: cefotaxime; ciprofloxacin; cefotaxime-plus-ciprofloxacin;...
Redox balance has been suggested as an important determinant of "stemness" in embryonic stem cells (ESCs). In this study, we demonstrate that peroxiredoxin (Prx) plays a pivotal role maintenance ESC stemness during neurogenesis through suppression reactive oxygen species (ROS)-sensitive signaling. During neurogenesis, Prx I and Oct4 are expressed mutually dependent manner their expression is abruptly downregulated by excess ROS. Thus, I(-/-) or II(-/-) ESCs, rapid loss can occur due to...