Ohmyungsamycins A and B (1 2), which are new cyclic peptides, were isolated from a marine bacterial strain belonging to the Streptomyces genus collected sand beach on Jeju, volcanic island in Republic of Korea. Based interpretation NMR, UV, IR spectroscopic MS data, planar structures 1 2 elucidated as depsipeptides bearing unusual amino acid units, including N-methyl-4-methoxytrytophan, β-hydroxyphenylalanine, N,N-dimethylvaline. The absolute configurations α-carbons residues determined...

Sungsanpin (1), a new 15-amino-acid peptide, was discovered from Streptomyces species isolated deep-sea sediment collected off Jeju Island, Korea. The planar structure of 1 determined by 1D and 2D NMR spectroscopy, mass spectrometry, UV spectroscopy. absolute configurations the stereocenters in this compound were assigned derivatizations hydrolysate with Marfey's reagents 2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl isothiocyanate, followed LC-MS analysis. Careful analysis ROESY spectrum...

There is an increasing need for objective grading system to evaluate the severity of dry eye disease (DED). In this study, a fully automated deep learning-based assessment DED was developed. Corneal fluorescein staining (CFS) images patients from one hospital development (n = 1400) and another external validation 94) were collected. Three experts graded CFS using NEI scale, median value used as ground truth. The developed in three steps: (1) corneal segmentation, (2) candidate region...

Bahamaolides A and B (1 2), two new 36-membered macrocyclic lactones, were isolated from the culture of marine actinomycete Streptomyces sp. derived a sediment sample collected at North Cat Cay in Bahamas. The planar structures 1 2, bearing hexaenone nine consecutive skipped hydroxy groups, determined by 1D 2D NMR, mass, IR, UV spectra. absolute configurations bahamaolides established combined multistep chemical reactions spectroscopic analysis. Bahamaolide displayed significant inhibitory...

Purpose: To evaluate the accuracy of toric intraocular lens (IOL) axis prediction between two preoperative measurement devices: optical biometry (IOLMaster 500 or 700) and dual Scheimpflug topography (Galilei G4)Methods: Medical records 64 eyes from 44 patients who underwent phacoemulsification posterior chamber IOL (Zeiss AT TORBI 709M) implantation July 2017 January 2022 were reviewed.All evaluation by IOLMaster Galilei G4.The gold-standard that minimizes astigmatism was calculated online...

To evaluate the long-term efficacy, safety, and prognostic factors of pulsed-light accelerated corneal collagen cross-linking (A-CXL) with continuous riboflavin application to halt keratoconus progression. A-CXL retention ring-assisted for either 10- or 5-min was performed in 37 eyes 33 patients progressive between 2016 2020. Successful halting rates time-dependent changes keratometric values, visual acuity, refractive errors, topographic indices, central thickness (CCT), thinnest (TCT),...

Coprisidins A and B (1 2) were isolated from a gut-associated Streptomyces sp. in the dung beetle Copris tripartitus. Using combination of spectroscopic techniques, structures compounds determined to be first examples natural naphthoquinone–oxindole alkaloids. Coprisidin was found inhibit action Na+/K+-ATPase, coprisidin showed activity for induction NAD(P)H:quinone oxidoreductase 1.

Six new meroterpenoids (1-6), along with arenarol (7), a known rearranged drimane sesquiterpene hydroquinone, were isolated from Dysidea sp. sponge collected the Federated States of Micronesia. On basis results combined spectroscopic analysis, compound 1 was determined to be cyclic ether derivative 7, whereas 2 and 3 assigned as corresponding quinones containing taurine-derived substituents. Compounds 4-6 possess novel tetracyclic skeleton formed by direct linkage between quinone moieties....

Salternamides A–D (1–4), the first secondary metabolites discovered from saltern-derived actinomycetes, were isolated a halophilic Streptomyces strain saltern on Shinui Island in Republic of Korea. The planar structures salternamides, which are new members manumycin family, elucidated by combination spectroscopic analyses. absolute configurations salternamides determined chemical and methods, including modified Mosher's method, J-based configuration analysis, circular dichroism spectroscopy....

Chemical investigation of a halophilic actinomycete strain belonging to the genus Nocardiopsis inhabiting hypersaline saltern led discovery new 18-membered macrolides with nitrile functionality, borrelidins C–E (1–3), along previously reported borrelidin (4). The planar structures C–E, which are members rare class antibiotics, were elucidated by NMR, mass, IR, and UV spectroscopic analyses. configurations borrelidines determined interpretation ROESY NMR spectra, J-based configuration...

Nine new compounds, tris-aromatic furanones (1, 2, 3a, 3b, and 4) related bis-aromatic diesters (5a, 5b, 6a, 6b), are described from the ascidian Synoicum sp. collected off coast of Chuja-do, Korea. The structures these designated as cadiolides E G–I (1–4) synoilides A B (5 6), were determined by extensive spectroscopic analyses. absolute configuration at asymmetric center cadiolide G (2) was assigned ECD analysis. Of I possess unprecedented carbon skeletons. Several compounds exhibited...

Tripartilactam, a structurally unprecedented cyclobutane-bearing tricyclic lactam metabolite, was discovered from Streptomyces sp. isolated brood ball of the dung beetle, Copris tripartitus. The structure this compound elucidated by combination NMR, MS, UV, and IR spectroscopy multistep chemical derivatization. Tripartilactam evaluated as Na+/K+ ATPase inhibitor (IC50 = 16.6 μg/mL).

Three new secondary metabolites, amycofuran (1), amycocyclopiazonic acid (2), and amycolactam (3), were isolated from the sponge-associated rare actinomycete Amycolatopsis sp. Based on combined spectroscopic analyses, structures of 1–3 determined to be a benzofuran glycoside indole alkaloids related cyclopiazonic acids, class that has previously only been reported in fungi. The absolute configurations 1 3 deduced by ECD calculations, whereas 2 was using modified Mosher method. Amycolactam...

Hypoxia inducible factor-1α (HIF-1α) is an essential regulator of the cellular response to low oxygen concentrations, activating a broad range genes that provide adaptive responses deprivation. HIF-1α overexpressed in various cancers and therefore represents considerable chemotherapeutic target. Salternamide A (SA), novel small molecule isolated from halophilic Streptomyces sp., potent cytotoxic agent against variety human cancer cell lines. However, mechanisms by which SA inhibits tumor...

Laparoscopic cholecystectomy (LC) is the standard management for acute cholecystitis. Percutaneous transhepatic gallbladder drainage (PTGBD) may be an alternative interim strategy before surgery in elderly patients with comorbidities. This study was designed to evaluate safety and efficacy of PTGBD (>60 years) cholecystitis.We reviewed consecutive diagnosed cholecystitis between January 2009 December 2013. Group I included who underwent PTGBD, group II did not undergo LC.All 116 (72.7 ± 7.1...

Lajollamycins (1–4), each of which bears a spiro-β-lactone-γ-lactam ring and nitro-tetraene moiety, were obtained from marine-derived Streptomyces strain isolated the southern area Jeju Island, Republic Korea. The planar structures lajollamycins elucidated on basis spectroscopic analyses by NMR, UV, IR, MS. absolute configuration lajollamycin (1), structure has been previously reported, was determined using J-based analysis based 1H–1H 1H–13C coupling constants, as well ROESY correlations,...

Gombaspiroketals A–C (1–3), tetracyclic sesterterpenes of a novel skeletal class, were isolated from the Korean marine sponge Clathria gombawuiensis. On basis combined spectroscopic analyses, structures these compounds determined to be highly rearranged sesterterpene spiroketal methoxyacetals (1 and 2) corresponding hemiacetal (3). The relative absolute configurations assigned by NOESY analysis ECD calculations, respectively. These exhibited moderate cytotoxicities antibacterial activities.

Asperphenins A (1) and B (2), novel diastereomeric lipopeptidyl benzophenone metabolites, were isolated from a marine-derived Aspergillus sp. fungus. On the basis of results combined spectroscopic analyses, structures these compounds determined to be linear assemblies three motifs: hydroxy fatty acid, tripeptide, trihydroxybenzophenone. The absolute configurations assigned using chemical modifications electronic circular dichroism (ECD) calculations. exhibited significant cytotoxicity on...

Purpose: To evaluate the characteristics of ocular biometric parameters in adult Korean patients with cataract. Setting: Department Ophthalmology, Seoul National University Hospital, Seoul, South Korea. Design: Retrospective case series. Methods: Ocular values 5273 eyes undergoing cataract surgery measured IOLMaster 700 at Hospital between November 2019 and December 2021 were reviewed. Results: A total analyzed. The mean ± SD age was 66.1 12.8 years, 62% female. Overall, correlated each...

Six seongsanamides were isolated from the culture broth of Bacillus safensis KCTC 12796BP, and their structures elucidated by spectroscopic data analysis combined with Marfey's method, electronic circular dichroism calculations, biosynthetic gene cluster analysis. Compounds 1–4 bicyclic peptides isodityrosine residues; 5 6 monocyclic peptides. Only inhibited degranulation LTC4/PGD2 generation in IgE/Ag-stimulated bone marrow-derived mast cells. Oral administration 1 suppressed cell-dependent...