A5074593036- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Xenotransplantation and immune response
- Ophthalmology and Visual Impairment Studies
- Ocular Infections and Treatments
- Intraocular Surgery and Lenses
- Sperm and Testicular Function
- Animal Genetics and Reproduction
- Salivary Gland Disorders and Functions
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- melanin and skin pigmentation
- Allergic Rhinitis and Sensitization
- Gut microbiota and health
- Eosinophilic Disorders and Syndromes
- Traumatic Brain Injury and Neurovascular Disturbances
- Parallel Computing and Optimization Techniques
- Genetic and rare skin diseases.
- Mesenchymal stem cell research
- Ocular Oncology and Treatments
- Nutrition, Health and Food Behavior
- Virus-based gene therapy research
- Cancer and Skin Lesions
Seoul National University Hospital
2016-2025
Seoul National University
2014-2025
New Generation University College
2013-2025
Biomedical Research Institute
2025
Chonnam National University Hospital
2024
Catholic University of Korea
2024
Chonnam National University
2024
Korea University
2024
Yonsei University
2023-2024
Samsung Medical Center
2022
To investigate gut dysbiosis in patients with Sjögren's syndrome (SS) or dry eye (DES) compared to normal subjects and evaluate the association of severity.10 SS, 14 DES 12 controls were enrolled. Corneal staining, tear break up time (TBUT) secretion evaluated. Bacterial genomic 16s rRNA from stool samples analyzed. Main outcomes microbiome compositional differences among groups their correlation signs.Gut analysis revealed significant SS DES. In phylum, Bacteriodetes increased, while...
The cornea is a transparent tissue devoid of blood and lymphatic vessels. However, various inflammatory conditions can cause hemangiogenesis lymphangiogenesis in the cornea, compromising transparency visual acuity. Mesenchymal stem/stromal cells (MSCs) have therapeutic potentials variety diseases because anti-inflammatory properties. Herein, we investigated effects MSCs on corneal angiogenesis using model suture-induced neovascularization. Data demonstrated that an intravenous administration...
We evaluated the accuracy of augmented reality (AR)-based navigation assistance through simulation bone tumours in a pig femur model.We developed an AR-based system for tumour resection, which could be used on tablet PC. To simulate femur, cortical window was made diaphysis and cement inserted. A total 133 femurs were resection simulated with AR-assisted (164 82 femurs, half by orthropaedic oncology expert orthopaedic resident) conventional method (82 41 femurs). In group, performed after...
Background In various studies in adults, caffeine may increase wakefulness and relieve pain, but overdose can cause many adverse serious effects on health. Caffeine intake has recently been increasing adolescents. spite of importance Korean adolescents, there are lack scientific systematic studies. The purpose our study was to identify the relationship between consumption Methods We performed 234 middle school students at one Daegu using a self-report questionnaire. divided quartiles...
Abstract Background Precise measurement of ocular biometry is critical for determining intraocular lens power. Newly developed swept-source optical coherence tomography (SS-OCT) - based biometric devices, ANTERION and CASIA2 provide measurements as IOLMaster 700. This study aimed to assess agreement between three devices. Methods retrospective comparative includes patients with cataract who underwent ANTERION, CASIA2, 700, at Seoul National University Hospital, in April 2020. Anterior...
There is an increasing need for objective grading system to evaluate the severity of dry eye disease (DED). In this study, a fully automated deep learning-based assessment DED was developed. Corneal fluorescein staining (CFS) images patients from one hospital development (n = 1400) and another external validation 94) were collected. Three experts graded CFS using NEI scale, median value used as ground truth. The developed in three steps: (1) corneal segmentation, (2) candidate region...
The effect of hydroxychloroquine (HCQ) on dry eye has not been fully determined.This study aimed to compare the 12-week efficacy HCQ medication with that a placebo in management primary Sjögren's syndrome (pSS).A double-blind, randomized control was conducted 39 pSS subjects from May 2011 through August 2013.pSS diagnosed based classification criteria American-European Consensus Group.Subjects received 300 mg or once daily for 12 weeks and were evaluated at baseline, 6 weeks, re-visit 16...
It is not known how biological changes in the lacrimal (LGs) and meibomian (MGs) glands contribute to dry eye disease (DED) a time-dependent manner. In this study, we investigated time-sequenced inflammation, oxidative stress, senescence of stem cells both an aging-related DED mouse model. Eight-week (8W)-, one-year (1Y)-, two-year (2Y)-old C57BL/6 male mice were used. MG areas upper lower eyelids analyzed by transillumination meibography imaging. The number CD45+, 8-OHdG+, Ki-67+, BrdU+ was...
Abstract Background This study aimed to investigate the self-reported dissatisfaction rates and associated risk factors among patients who underwent cataract surgery using different types of presbyopia-correcting intraocular lenses (IOLs). Methods retrospective case–control analyzed medical records in 340 eyes from 211 with IOLs. The IOL included bifocal (ReSTOR®), trifocal (PanOptix®), extended depth-of-focus (EDOF; Symfony®) related vision or photic disturbances were compared between these...
To investigate the long-term efficacy and safety of posterior chamber implantable collamer lens (ICL) implantation in high myopia, risk factors associated with endothelial cell loss (ECL) or cataract development. Medical records 66 eyes 37 patients who underwent ICL for myopia were retrospectively analyzed a mean follow-up 12 years. Changes LogMAR best corrected visual acuity (BCVA), intraocular pressure (IOP), refractive power, density (ECD) over time incidence IOP elevation. Risk their...
To evaluate the long-term efficacy, safety, and prognostic factors of pulsed-light accelerated corneal collagen cross-linking (A-CXL) with continuous riboflavin application to halt keratoconus progression. A-CXL retention ring-assisted for either 10- or 5-min was performed in 37 eyes 33 patients progressive between 2016 2020. Successful halting rates time-dependent changes keratometric values, visual acuity, refractive errors, topographic indices, central thickness (CCT), thinnest (TCT),...
Abstract Purpose To investigate the changes in ocular biometry over time and their impact on intraocular lens (IOL) calculation adult Korean patients with cataracts. Methods Inclusion criteria were who underwent two consecutive biometric measurements spaced more than one year apart using IOLMaster 700 between November 2019 February 2024 at a tertiary hospital Seoul, Korea. Longitudinal evaluated. Predictive errors compared among cataract surgery SRK/T, Kane, Barrett Universal II, Cook K6,...
Abstract Background While aging is a potent risk factor of dry eye disease, age-related gut dysbiosis associated with inflammation and chronic geriatric diseases. Emerging evidence have demonstrated that contributes to the pathophysiology or exacerbation ocular diseases including disease. However, relationship between aging-related changes in microbiota disease has not been elucidated. In this pilot study, we investigated association aging-dependent microbiome severity C57BL/6 male mice....
Recently, REpresentational State Transfer (REST) has been proposed as an alternative architecture for Web services.In the era of Cloud and 2.0, many complex service-based systems such e-Business de-Government applications have adopted REST. Unfortunately, REST approach applied to few cases in management systems, especially a system cloud computing infrastructures.In this paper, we design implement RESTful Management System (CMS).Managed elements can be modeled resources operations existing...
Pterygium is an abnormal growth of fibrous conjunctival tissue that invades the cornea, resulting in corneal distortion, astigmatism, and increased higher-order aberrations (HOAs). However, few studies have compared eyes with pterygium to normal fellow when interpreting HOAs there no study revealed effect thickness or grading on change HOAs. Therefore, we evaluated effects nasal by comparing eye 59 patients. The significantly with-the-rule astigmatism irregularity. Trefoils, horizontal coma,...
Purpose: To evaluate the characteristics of ocular biometric parameters in adult Korean patients with cataract. Setting: Department Ophthalmology, Seoul National University Hospital, Seoul, South Korea. Design: Retrospective case series. Methods: Ocular values 5273 eyes undergoing cataract surgery measured IOLMaster 700 at Hospital between November 2019 and December 2021 were reviewed. Results: A total analyzed. The mean ± SD age was 66.1 12.8 years, 62% female. Overall, correlated each...
Abstract Background Safety concerns exist for corneal recipients under immunosuppression. We report long‐term safety results of porcine xenotransplantation immunosuppression in nonhuman primates. Methods Systemic monitoring data from 49 Chinese rhesus macaques that received pig transplant between 2009 and 2018 were retrospectively reviewed. The divided into 4 groups depending on the systemic immunosuppressants used: (a) conventional steroid group; costimulation blockade ([b] anti‐ CD 154...
ABSTRACT Cowden syndrome, also known as multiple hamartoma syndrome is a rare autosomal dominant disorder characterized by hamartomatous tumors of ectodermal, mesodermal and endodermal origin. A 47‐year‐old woman had skin‐colored plaque on the left foot. She total abdominal hysterectomy due to uterine leiomyoma at age 35, modified radical mastectomy right breast cancer 38. Thyroid adenoma was diagnosed 46. Physical examinations revealed macrocephaly, papules buccal mucosa, skin tags neck...