A5100413837- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Ophthalmology and Eye Disorders
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Retinal Diseases and Treatments
- Pituitary Gland Disorders and Treatments
- Retinal Imaging and Analysis
- Spine and Intervertebral Disc Pathology
- Xenotransplantation and immune response
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Visual Health Research
- Spinal Fractures and Fixation Techniques
- Gastric Cancer Management and Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Ocular Oncology and Treatments
- Advanced MRI Techniques and Applications
- Metastasis and carcinoma case studies
- Consumer Perception and Purchasing Behavior
- Esophageal and GI Pathology
- Otitis Media and Relapsing Polychondritis
Seoul National University Bundang Hospital
2020-2025
Seoul National University Hospital
2008-2024
Gachon University
2018-2023
Gachon University Gil Medical Center
2016-2023
Korea University
2023
Seoul National University
2008-2015
Dongguk University
2010
Memorial Hospital of South Bend
2009
The cornea is a transparent tissue devoid of blood and lymphatic vessels. However, various inflammatory conditions can cause hemangiogenesis lymphangiogenesis in the cornea, compromising transparency visual acuity. Mesenchymal stem/stromal cells (MSCs) have therapeutic potentials variety diseases because anti-inflammatory properties. Herein, we investigated effects MSCs on corneal angiogenesis using model suture-induced neovascularization. Data demonstrated that an intravenous administration...
To determine whether fat-signal-fraction (FF) map using a modified Dixon sequence could help differentiate benign from malignant bone lesions.Spine magnetic resonance images (MRIs) of 120 consecutive patients were studied by 3T MRI with standard T1 -weighted image (T1 WI) and modified-Dixon for FF measurement. There three groups: control group (n = 51) normal vertebrae; 40) focal red marrow deposition, Schmorl's nodes, compression fracture, or Modic type 1 endplate degeneration; 29) spinal...
Objective To compare the diagnostic performance of an artificial intelligence deep learning system with that expert neuro‐ophthalmologists in classifying optic disc appearance. Methods The was previously trained and validated on 14,341 ocular fundus photographs from 19 international centers. evaluated 800 new (400 normal discs, 201 papilledema [disc edema elevated intracranial pressure], 199 other abnormalities) compared 2 who independently reviewed same randomly presented images without...
Objective To evaluate the performance of a deep learning system (DLS) in classifying severity papilledema associated with increased intracranial pressure on standard retinal fundus photographs. Methods A DLS was trained to automatically classify 965 patients (2,103 mydriatic photographs), representing multiethnic cohort confirmed elevated pressure. Training performed 1,052 photographs mild/moderate (MP) and 1,051 severe (SP) classified by panel experts. The that 3 independent...
Abstract Vertebral compression fracture is a deformity of vertebral bodies found on lateral spine images. To diagnose fracture, accurate measurement ratio required. Therefore, rapid and segmentation vertebra important for measuring the ratio. In this study, we used 339 data thoracic lumbar images training testing deep learning model segmentation. The result by was compared with manual measurement, which performed specialist. As result, average sensitivity dataset 0.937, specificity 0.995,...
Background/Objectives: We wished to develop an automated method for quantifying fusion control in patients with intermittent exotropia (IXT) using eye tracking device. Methods: Fifty subjects fixated on visual targets LCD monitor at a distance of 45 cm, consisting dots moving horizontally and vertically randomly appearing fixed positions. The group consisted participants less than 5 prism diopters (PD), the IXT 10 PD or more, excluding divergence excess types. Fixation disparity (FD) was...
Background/Objectives: This study aimed to investigate the efficacy of topical dopamine administration in inhibiting form deprivation (FD) myopia a rabbit model. Methods: A total 16 neonatal New Zealand white rabbits were randomly assigned two groups: control group and treatment group. FD was induced both groups by applying light diffuser one eye. The received daily instillations 4% eye with myopia, while normal saline over four-week period. Axial length measurements taken assess degree...
Purpose: To investigate the therapeutic potential of TNF-α stimulated gene/protein (TSG)-6 in two mouse models inflammation-mediated dry eye syndrome (DES). Methods: We created DES mice by injecting concanavalin A (ConA; 10 mg/mL) into intraorbital and extraorbital lacrimal glands. Recombinant TSG-6 (1 μg phosphate-buffered solution [PBS]) or same volume PBS was administered topically to eyes four times a day (QID) for 1 week. In parallel experiments, we applied μg) QID 12-week-old...
Abstract Background Xenocorneal transplantation is one of the solutions for shortage donor cornea, and remarkable advances have been made in pig‐to‐rhesus studies from immunological perspective. Most successful preclinical trials carried out with corneas Seoul National University ( SNU ) miniature pig pig, genetically unmodified) as tissues; however, there has no biophysico‐functional evaluation cornea a substitute human cornea. The purpose this study was to investigate biophysical...
Several transscleral suturing techniques require intricate surgical maneuvers and are associated with an increased risk for trauma. We describe a new scleral fixation method that combines the advantages of temporary haptic externalization injector implantation intraocular lens (IOL). After IOL insertion injector, each is externalized through 2 adjacent corneal incisions. A 10-0 polypropylene suture loop made at exposed performed. This modified technique safe effective way to fixate in eyes...
Abstract The long-term results of surgical treatment intermittent exotropia (X(T)) according to the type surgery are controversial. We conducted a retrospective cohort study compare between unilateral recession-resection (RR) and bilateral lateral rectus recession (BLR) with an average follow-up 9.5 years in children basic-type X(T). Patients X(T), who underwent RR (RR group) or BLR (BLR were followed-up for more than 5 postoperatively, analyzed. Of 560 patients, 363 patients received 197...
Extracellular high mobility group box 1 (HMGB1) acts as a damage associated molecular pattern molecule through the Toll-like receptor to promote autoreactive B cell activation, which may be involved in pathogenesis of Sjӧgren's syndrome. The aim this study was investigate effect subconjunctival administration anti-HMGB1 on dry eye mouse model syndrome.Ten weeks-old NOD.B10.H2b mice were subconjunctivally injected with 0.02 2 μg antibodies or PBS twice week for two consecutive weeks. Tear...
Abstract Shortage of donor cornea is a significant problem in Asia, and xenocorneal transplantation being actively studied to alleviate this problem. However, the attitudes subjects who await corneal transplants toward are not known at all. Thus, study aimed investigate on waiting lists for transplants, xenotransplantation. A telephone questionnaire survey comprising six items was conducted 132 among wait‐listed individuals (n = 590) were awaiting or had undergone Seoul National University...
Purpose: To investigate the feasibility of estimating effective lens position (ELP) and calculating intraocular power using corneal height (CH), as measured anterior segment optical coherence tomography (AS-OCT), in patients who have undergone refractive surgery.Methods: This study included 23 (30 eyes) myopic surgery subsequent successful cataract surgery.The CH was with AS-OCT, ELP (ELP m ) calculated.Intraocular power, which could achieve actual emmetropia (P real ), determined medical...
Purpose: To compare the effects of performing a single limbal relaxing incision (LRI) combined with clear corneal on astigmatism that paired LRIs in cataract surgery.Methods: Medical records for 25 eyes 20 patients who had undergone during operations with-the-rule 1.5 diopters (D) or more topography were retrospectively reviewed.Single assigned randomly and performed steepest axis; degrees arc determined using modified Gills nomogram.A wound was made vertical axis.Uncorrected visual acuity...
To evaluate the therapeutic effects of topical 8-oxo-2'-deoxyguanosine (8-oxo-dG) on experimental ocular chemical injury models.We created models with 8-week-old BALB/c mice (n = 70) by applying 100% ethanol; were then treated 8-oxo-dG eye drops 10 and 5 mg/mL phosphate-buffered saline (PBS) twice daily. After 7 days, clinical findings such as corneal integrity, clarity, neovascularization assessed. Histology, immunohistochemistry findings, inflammatory cytokine levels using real-time...
To investigate the clinical characteristics of patients with Mooren's ulcer in Korean population, and to identify risk factors that affect therapeutic outcome.We reviewed medical records 33 eyes 24 who were referred a cornea clinic clinically diagnosed ulcer.Despite intensive immunosuppression, corneal perforation occurred 16 (66.7%) patients, which required tectonic graft. Age was significantly correlated development: age 52.5 ± 21.8 years 70.2 6.1 those without (p = 0.036). Also, all 8 55...
To investigate the efficacy of botulinum toxin injection without electromyographic guidance for treatment consecutive esotropia.A retrospective study was performed on 49 subjects with esotropia who received in medial rectus muscles use guidance. Treatment considered successful if final ocular alignment orthotropic or esodeviation ≤10 prism diopters (PD) during distant fixation.The mean age 15.2 ± 8.3 years. The before 21.8 9.1 PD at distance and 21.3 near. number injections per patient 1.3...
To report a case of primary conjunctival epithelial inclusion cyst with atypical manifestation.A 66-year-old woman presented yellowish, subconjunctival mass extending from the corneal limbus to medial canthus in left eye. Clinical, radiological and histological assays were performed.The was well-delineated, overlying conjunctiva normal. An enhanced axial orbit computed tomography scan showed 7.7 × 3.6 mm, well-demarcated, convex-shaped mass. Neither connection orbital area nor extrusion...
서울대학교 의과대학 안과학교실, 서울대학교병원 의생명연구원 인공안구센터 안면역각막재생연구실, 순천향대학교 구미병원 안과학교실 Department of Ophthalmology, Seoul National University College Medicine, Seoul, Korea Laboratory Ocular Regenerative Medicine and Immunology, Artificial Eye Center, Hospital Biomedical Research Institute, Soonchunhyang Gumi Hospital, Gumi,
Abstract We conducted a prospective study to evaluate the efficacy of simulation-based education using three-dimensional (3D)-printed schematic eye model in improving retinoscopy refraction skills medical students. A was printed fused deposition modeling-based 3D printer. Twenty students randomized into (n = 10) and control groups received 1-h lecture on principles methods manifest were shown how use retinoscope sciascope bars. The group additionally attended tutorial eye. Both performed...