Philippe Gohier
A5075813376- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- Ophthalmology and Visual Health Research
- Retinal Imaging and Analysis
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Ocular Infections and Treatments
- Mitochondrial Function and Pathology
- Pharmaceutical Practices and Patient Outcomes
- Metabolomics and Mass Spectrometry Studies
- IgG4-Related and Inflammatory Diseases
- Salivary Gland Disorders and Functions
- Ocular Oncology and Treatments
- Genomics and Rare Diseases
- Intraoperative Neuromonitoring and Anesthetic Effects
- Surgical Simulation and Training
- Optical Imaging and Spectroscopy Techniques
- Corneal surgery and disorders
- ATP Synthase and ATPases Research
- Drug-Induced Ocular Toxicity
- Migraine and Headache Studies
- Anesthesia and Pain Management
Université d'Angers
2008-2025
Centre Hospitalier Universitaire d'Angers
2013-2024
Centre Hospitalier Universitaire de Bordeaux
2023-2024
Hôpital Cardiologique du Haut-Lévêque
2023-2024
Hôpital Pellegrin
2023
Inserm
2021
Centre National de la Recherche Scientifique
2021
Centre Hospitalier Universitaire de Toulouse
2018
Université Nantes Angers Le Mans
2013-2016
Nonophthalmologist physicians do not confidently perform direct ophthalmoscopy. The use of artificial intelligence to detect papilledema and other optic-disk abnormalities from fundus photographs has been well studied.We trained, validated, externally tested a deep-learning system classify optic disks as being normal or having 15,846 retrospectively collected ocular that had obtained with pharmacologic pupillary dilation various digital cameras in persons multiple ethnic populations. Of...
Purpose: To investigate the plasma concentration of nicotinamide in primary open-angle glaucoma (POAG). Methods: Plasma 34 POAG individuals was compared to that 30 age- and sex-matched controls using a semiquantitative method based on liquid chromatography coupled high-resolution mass spectrometry. Subsequently, an independent quantitative method, spectrometry, used assess from same initial cohort replicative 20 15 controls. Results: Using significantly lower further confirmed cohort,...
To determine the plasma metabolomic signature of primary open-angle glaucoma (POAG).We compared profiles from individuals with POAG (n = 36) age- and sex-matched controls cataract 27). A targeted metabolomics study was performed using standardized p180 Biocrates Absolute IDQ kit a QTRAP 5500 mass spectrometer. Multivariate analyses were principal component analysis (PCA) least absolute shrinkage selection operator (LASSO) method.Among 151 metabolites accurately measured, combined univariate...
We compared the metabolomic profile of aqueous humor from patients with primary open-angle glaucoma (POAG; n = 26) that a group age- and sex-matched non-POAG controls (n 26), all participants undergoing cataract surgery. Supervised paired partial least-squares discriminant analysis showed good predictive performance for test sets median area under receiver operating characteristic 0.89 p-value 0.0087. Twenty-three metabolites allowed discrimination between two groups. Univariate after...
Objective To evaluate the performance of a deep learning system (DLS) in classifying severity papilledema associated with increased intracranial pressure on standard retinal fundus photographs. Methods A DLS was trained to automatically classify 965 patients (2,103 mydriatic photographs), representing multiethnic cohort confirmed elevated pressure. Training performed 1,052 photographs mild/moderate (MP) and 1,051 severe (SP) classified by panel experts. The that 3 independent...
Abstract Background The dysfunction of OPA1, a dynamin GTPase involved in mitochondrial fusion, is responsible for large spectrum neurological disorders, each which includes optic neuropathy. database dedicated to OPA1 ( https://www.lovd.nl/OPA1 ), created 2005 , has now evolved towards centralized and more reliable using the Global Variome shared Leiden Open-source Variation Database (LOVD) installation. Results updated database, registers all patients from our center as well those reported...
Hereditary optic neuropathies are caused by the degeneration of retinal ganglion cells whose axons form nerves, with a consistent genetic heterogeneity. As part our diagnostic activity, we retrospectively evaluated combination Leber hereditary neuropathy mutations testing exon sequencing 87 nuclear genes on 2186 patients referred for suspected neuropathies. The positive diagnosis rate in individuals was 18% (199/1126 index cases), 92% (184/199) carrying one three main pathogenic variants...
•The Brain and Optic Nerve Study Artificial Intelligence (BONSAI) deep learning system was able to reliably identify papilledema normal optic discs on photographs obtained in the Fundus photography vs Ophthalmoscopy Trial Outcomes Emergency Department (FOTO-ED) studies.•This previously trained high-quality mydriatic fundus performed very well nonmydriatic ocular photographs.•Our has excellent potential as a diagnostic aid emergency departments nonophthalmology clinics equipped with cameras....
Glaucoma is an age related disease characterized by the progressive loss of retinal ganglion cells, which are neurons that transduce visual information from retina to brain. It leading cause irreversible blindness worldwide. To gain further insights into primary open-angle glaucoma (POAG) pathophysiology, we performed a non-targeted metabolomics analysis on plasma POAG patients (n = 34) and age- sex-matched controls 30). We investigated differential signature compared controls, using liquid...
Biallelic mutations in ACO2, encoding the mitochondrial aconitase 2, have been identified individuals with neurodegenerative syndromes, including infantile cerebellar retinal degeneration and recessive optic neuropathies (locus OPA9). By screening European cohorts of genetically unsolved inherited neuropathies, we 61 cases harbouring variants among whom 50 carried dominant mutations, emphasizing for first time important contribution ACO2 monoallelic pathogenic to atrophy. Analysis...
To report the clinical presentation and follow-up, including optical coherence tomography, angiography electrophysiology of two individuals from same family presenting with an isolated retinal dystrophy optic nerve edema who were diagnosed ROSAH-like syndrome. Observational case a 55-year-old woman her 36-year-old son genetic analysis ROSAH, after long-term follow-up. Both mother displayed severe infiltration pigment atrophy intraocular inflammation, which not improved by immunosuppressive...
To determine the plasma metabolomic profile of exudative age-related macular degeneration (AMD), we performed a targeted metabolomics study on from patients (n = 40, mean age 81.1) compared to an age- and sex-matched control group 81.8). All included had documented AMD, causing significant visual loss (mean logMAR acuity 0.63), group. Patients controls did not differ in terms body mass index co-morbidities. Among 188 metabolites analyzed, 150 (79.8%) were accurately measured. The...
The aim of this study was to describe the outcomes targeted COVID-19 treatments in immunocompromised patients with asymptomatic or mild during period expansion different Omicron subvariants France. A retrospective monocentric observational performed. All aged 18 more, SARS-CoV-2 infection COVID-19, and who had received a treatment sotrovimab, tixagevimab/cilgavimab, nirmatrelvir/ritonavir remdesivir at Bordeaux University Hospital from 1st January 2022 31st December were eligible. primary...
Purpose: To compare the pupil dynamics of an intracameral combination 2 mydriatics and 1 anesthetic (Mydrane) to a standard topical regimen for cataract surgery. Setting: Sixty-two centers in Europe 6 Algeria. Design: Prospective case series. Methods: Pupil size measurements were performed randomized studies (phase phase 3) under masked conditions (recorded videography, reading center). The outcomes study supported evaluation timeframe obtain dilation 3 provided results on mydriasis...
To determine the plasma metabolomic signature of exfoliative syndrome (XFS), most common cause worldwide secondary open-angle glaucoma.We performed a targeted study, using standardized p180 Biocrates Absolute IDQ kit with QTRAP 5500 mass spectrometer, to compare profiles from individuals XFS (n = 16), and an age- sex-matched control group cataract 18).A total 151 metabolites were detected correctly, 16 which allowed for construction OPLS-DA model good predictive capability (Q2cum 0.51)...
Pathogenic variants of the nuclear receptor subfamily 2 group F member 1 gene (NR2F1) are responsible for Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS), an autosomal dominant disorder characterized by associated with developmental delay and intellectual disability, but a clinical presentation which appears to be multifaceted. We created first public locus-specific database dedicated NR2F1. All cases reported in literature, as well new unpublished cases, were integrated into using...
About half of patients with Graves' disease develop an orbitopathy related to inflammatory expansion the periorbital adipose tissue and muscles. We used a targeted metabolomic approach measuring 188 metabolites by mass spectrometry compare metabolic composition tears in active (n = 21) versus inactive 24) thyroid-associated orbitopathy. Among 44 accurately measured, 8 showed significant alteration their concentrations between two groups. Two short-chain acylcarnitines, propionylcarnitine...