A5056745588- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Smoking Behavior and Cessation
- Colorectal Cancer Treatments and Studies
- Occupational and environmental lung diseases
- Obstructive Sleep Apnea Research
- Cancer therapeutics and mechanisms
- Cancer survivorship and care
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Neuroscience of respiration and sleep
- Cystic Fibrosis Research Advances
- Tuberous Sclerosis Complex Research
- Cannabis and Cannabinoid Research
- Multiple and Secondary Primary Cancers
- Pleural and Pulmonary Diseases
- Patient-Provider Communication in Healthcare
- Palliative Care and End-of-Life Issues
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
Centre Hospitalier Universitaire d'Angers
2014-2024
Sutter Health
2024
Dolby (United States)
2024
Université d'Angers
2013-2023
Inserm
2008-2020
Université Bretagne Loire
2017-2020
Centre National de la Recherche Scientifique
2020
Service de la Santé Publique
2018-2019
Université Nantes Angers Le Mans
2012-2016
Micro et Nanomédecines translationnelles
2012-2016
HER2 mutations are identified in approximately 2%of non-small-cell lung cancers (NSCLC). There few data available that describe the clinical course of patients with HER2-mutated NSCLC. We retrospectively 65 NSCLC, diagnosed a in-frame insertion exon 20. collected clinicopathologic characteristics, patients' outcomes, and treatments. mutation was (1.7%) 3,800 tested almost an exclusive driver, except for one single case concomitant KRAS mutation. Our population presented median age 60 years...
This study reports 2-year survival outcomes among patients with advanced nonprogressive stage IIA to IV lung cancer randomized symptom monitoring during chemotherapy via web-based patient-reported vs standard scheduled imaging after treatment detect symptomatic recurrence.
The use of web-based monitoring for lung cancer patients is growing in interest because promising recent results suggesting improvement and resource utilization outcomes. It remains an open question whether the overall survival (OS) these could be improved by using a web-mediated follow-up rather than classical scheduled imaging.Advanced-stage without evidence disease progression after or during initial treatment were randomly assigned multicenter phase III trial to compare algorithm...
Rationale: Elexacaftor-tezacaftor-ivacaftor is a CFTR (cystic fibrosis [CF] transmembrane conductance regulator) modulator combination, developed for patients with CF at least one Phe508del mutation. Objectives: To evaluate the effects of elexacaftor-tezacaftor- ivacaftor in and advanced respiratory disease. Methods: A prospective observational study, including all aged ⩾12 years percent-predicted FEV1 (ppFEV1) <40 who initiated elexacaftor-tezacaftor-ivacaftor from December 2019 to August...
Abbreviations used in this article: CT, computed tomography; FEV1, forced expiratory volume 1 second; FVC, vital capacity; KCO, carbon monoxide transfer coefficient; LAM, lymphangioleiomyomatosis; RV, residual volume; SD, standard deviation; TLC, total lung TLCO, factor, TSC, tuberous sclerosis.
The aim of this cross-sectional study was to evaluate the frequency type-2 diabetes and impaired glucose tolerance (IGT) in a large clinic-based male population presenting various degrees obstructive sleep apnoea syndrome (OSAS) analyse relationship between OSAS glucose-insulin metabolism. Male patients (n=595) with suspected underwent both nocturnal polysomnography 2-h oral glucose-tolerance test measurements fasting postload blood plasma insulin. Insulin sensitivity evaluated by ratio...
Rationale: Lumacaftor-ivacaftor is a CFTR (cystic fibrosis transmembrane conductance regulator) modulator combination recently approved for patients with cystic (CF) homozygous the Phe508del mutation.Objectives: To evaluate safety and effectiveness of lumacaftor-ivacaftor in adolescents (≥12 yr) adults (≥18 real-life postapproval setting.Methods: The study was conducted 47 CF reference centers France. All who initiated from January 1 to December 31, 2016, were eligible. Patients evaluated...
The aim of this study was to analyze the features superior vena cava syndrome (SVCS) as initial characteristics in small-cell lung cancer: incidence, dissemination disease, diagnostic procedures, efficacy and toxic effects chemotherapy, median survival patients with SVCS.In a prospective series 724 biopsy-proved cancer seen during 6-year period, we reviewed data from who also had SVCS.The incidence SVCS 87 at time diagnosis. Initial emergency radiation therapy not used these patients....
The c-Ki-ras oncogene (also known as KRAS2) is activated by point mutations involving codon 12 in 72%-100% of primary pancreatic adenocarcinomas, but the gene not nonneoplastic tissues. Therefore, detection can facilitate diagnosis which are always identified with current tests. Detection usually performed oligonucleotide hybridization combined polymerase chain reaction (PCR), RNAse mismatch cleavage assay, or non-isotopic mismatched PCR, methods that feasible for routine screening large...
LBA8507 Background: To date, no treatment is recommended in MPM pts progressing after 1 st -line pemetrexed-platinum doublet. Disease control rate (DCR) <30% with all drugs tested 2 nd setting. Preliminary results suggested possible activity of anti-PD-1 mAb /3 rd- line, opposed to single agent anti-CTLA-4 mAb. Therefore anti-PD1 efficacy deserves confirmation, and + combination value currently unknown MPM. Methods: In this multicenter randomized non comparative phase trial, eligible had...
MDR1 P-glycoprotein (Pgp 170), a member of the adenosine triphosphate (ATP) binding cassette transporters, acts as an efflux pump for various hydrophobic agents, particularly xenobiotics such benzo(a)pyrene. It has also been shown to regulate cell-volume activated chloride channels. Pgp 170 could, therefore, be particular importance in cellular mechanisms defence airways and control mucus layer composition. For these reasons, we evaluated precise localization human adult airways. Fresh...