A5021234055- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Cystic Fibrosis Research Advances
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Delphi Technique in Research
- Occupational and environmental lung diseases
- Inhalation and Respiratory Drug Delivery
- Cancer survivorship and care
- Chronic Disease Management Strategies
- Cardiovascular and exercise physiology
- Healthcare Systems and Practices
- Obstructive Sleep Apnea Research
- Cardiac Health and Mental Health
- Antifungal resistance and susceptibility
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Tracheal and airway disorders
- Hip and Femur Fractures
- Tryptophan and brain disorders
- Lung Cancer Diagnosis and Treatment
- Health, psychology, and well-being
Center for Infection and Immunity of Lille
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Université de Lille
2016-2025
Centre Hospitalier Universitaire de Lille
2016-2025
Inserm
2016-2025
Institut Pasteur de Lille
2016-2025
Hôpital Cardiologique du Haut-Lévêque
2024
Centre Hospitalier Universitaire de Bordeaux
2024
Hôpital Albert Calmette
2010-2022
Fondation de France
2022
Rationale: Elexacaftor-tezacaftor-ivacaftor is a CFTR (cystic fibrosis [CF] transmembrane conductance regulator) modulator combination, developed for patients with CF at least one Phe508del mutation. Objectives: To evaluate the effects of elexacaftor-tezacaftor- ivacaftor in and advanced respiratory disease. Methods: A prospective observational study, including all aged ⩾12 years percent-predicted FEV1 (ppFEV1) <40 who initiated elexacaftor-tezacaftor-ivacaftor from December 2019 to August...
Rationale: Limited data exist on safety and effectiveness of elexacaftor-tezacaftor-ivacaftor (ETI) in people with cystic fibrosis (pwCF) advanced lung disease. Objective: To evaluate the effects ETI an unselected population pwCF Methods: A prospective observational study, including all adults, aged 18 years older, a percent predicted FEV1 (ppFEV1)≤ 40 who initiated from December 2019 to June 2021 France was conducted. PwCF were followed until August 8th, 2022. Results: 434 median...
Introduction: Personalized, global pulmonary rehabilitation (PR) management of patients with COPD is effective, regardless the place in which this provided. The objective retrospective observational study was to long-term outcome exercise capacity and quality life during treated by home-based PR. Methods: Home-based PR administered 211 (mean age, 62.3±11.1 years; mean forced expiratory volume 1 second, 41.5%±17.7%). chosen because distance patient's home from center preference. Each patient...
Chronic obstructive pulmonary disease (COPD) is a major clinical challenge mostly due to cigarette smoke (CS) exposure. Invariant natural killer T (iNKT) cells are potent immunoregulatory that have crucial role in inflammation. In the current study, we investigate of iNKT COPD pathogenesis. The frequency activated NKT was found be increased peripheral blood patients relative controls. mice chronically exposed CS, accumulated lungs and strongly contributed detrimental confirmed an acute model...
Breathlessness is the prominent symptom of chronic obstructive pulmonary disease (COPD). Despite optimal therapeutic management including pharmacological and non-pharmacological interventions, many COPD patients exhibit significant breathlessness. Chronic breathlessness defined as that persists despite treatment underlying disease. Because major disability related to breathlessness, symptomatic treatments opioids have been recommended by several authors. The prevalence in its routine...
Azole-resistant Aspergillus fumigatus (ARAF) has been reported in patients with chronic obstructive pulmonary disease (COPD) but not specifically assessed so far. Here, we evaluated ARAF prevalence azole-naïve COPD and their homes, whether CYP51A mutations were similar clinical environmental reservoirs. Sixty respiratory samples from 41 acute exacerbation 36 of these patient's homes prospectively collected. A. was detected 11 (27%) 15 domiciles (42%). Cyp51A sequencing selection on...
Patients with advanced lung cancer (LC) or malignant pleural mesothelioma (MPM) exhibit limitation of exercise capacities and alteration quality life (QoL) induced by its treatment. Few studies assessed pulmonary rehabilitation (PR) in these chemotherapy-treated patients, none evaluated a home-based PR program. In this prospective uncontrolled observational pilot study, patients treated chemotherapy for LC MPM were screened program combining training global cares including therapeutic...
Objectives To evaluate the short-term and long-term benefits of adding a weekly educational session to traditional 8-week home-based pulmonary rehabilitation (PR) programme in people with chronic obstructive disease (COPD). Primary hypothesis was that 8 supervised sessions will be equivalent 16 at both short- after PR. Design Retrospective cohort study conducted on prospectively collected real-life data, from January 2010 December 2021. Setting FormAction Santé, Pérenchies France....
Background Chronic obstructive pulmonary disease (COPD) is a common treatable often diagnosed in patients with risk factors after prolonged period suggestive symptoms. Our qualitative study aimed to identify barriers establishing diagnosis the natural history of this condition. Methods An inductive thematic analysis was performed on structured interviews patients, general practitioners (GPs) and pulmonologists France. Inclusion depended criteria generate two purposive samples (patients...
Abstract Summary A retrospective study was conducted to calculate the cumulative incidence of hospital-initiated bone densitometry, in year following hospitalization for fragility fracture patients with chronic obstructive pulmonary disease. This cohort demonstrated low rates densitometry a 1-year 22.6%. Background Osteoporosis is one most frequent comorbidities disease (COPD) patients. assess management osteoporosis COPD using INCLUDE health data warehouse. Objectives The primary objective...
Progression of chronic obstructive pulmonary disease (COPD) is linked to episodes exacerbations caused by bacterial infections due Streptococcus pneumoniae. Our objective was identify during COPD, factors susceptibility among cytokine network and their role in COPD exacerbations. S. pneumoniae used sub-lethally challenge mice chronically exposed air or cigarette smoke (CS) stimulate peripheral blood mononuclear cells (PBMC) from non-smokers, smokers patients. The immune response the...
Background: Pulmonary rehabilitation (PR) is a key treatment of chronic obstructive pulmonary disease (COPD) but studies are still needed to identify the most pertinent criteria personalize this intervention and improve its efficacy. Objective: This real-life retrospective study compared effects home-based PR on exercise tolerance, anxiety, depression, health-related quality life (HRQoL) in COPD patients, according their medical equipment. Methods: Exercise HRQoL were evaluated 109 patients...
Background The prevalence of Achromobacter xylosoxidans lung isolation in cystic fibrosis (CF) patients has increased, but the impact on function is controversial. aim this study was to evaluate long-term effects A. respiratory adult with CF first 3 years after identification isolation. Methods This a case–control retrospective performed at single centre Lille, France. Data for 36 who had least one sputum culture positive ( Ax+ ) were evaluated and compared control uninfected by Ax− )....
Our objective was to evaluate the short-, medium- and long-term benefits of home-based pulmonary rehabilitation (PR) on physical affective components dyspnoea in people with fibrotic idiopathic interstitial pneumonias (f-IIPs). Anxiety depressive symptoms, fatigue, health-related quality life exercise tolerance were also assessed.
Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation and impaired immune response to pathogens leading bacteria-induced exacerbation of the disease. A defect in Th17 cytokines Streptococcus pneumoniae, a bacteria COPD exacerbations, has been recently reported. Dendritic cells (DC) are professional antigen presenting that drive T-cells differentiation activation. In this study, we hypothesized exposure cigarette smoke, main risk factor COPD, might altered...