A5010453820- Otitis Media and Relapsing Polychondritis
- Metabolomics and Mass Spectrometry Studies
- Vascular Anomalies and Treatments
- Salivary Gland Disorders and Functions
- Folate and B Vitamins Research
- Hemoglobinopathies and Related Disorders
- Birth, Development, and Health
- Cell Image Analysis Techniques
- Growth Hormone and Insulin-like Growth Factors
- Multiple Myeloma Research and Treatments
- Cardiac Imaging and Diagnostics
- Machine Learning in Bioinformatics
- Digital Imaging for Blood Diseases
- Cardiovascular Function and Risk Factors
- Streptococcal Infections and Treatments
- Iron Metabolism and Disorders
- Pregnancy and preeclampsia studies
- Metabolism and Genetic Disorders
- Infective Endocarditis Diagnosis and Management
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Thyroid Disorders and Treatments
- Ocular Surface and Contact Lens
- Immunotherapy and Immune Responses
- Neuroendocrine regulation and behavior
Dana-Farber Cancer Institute
2024-2025
Harvard University
2024
Broad Institute
2024
Inserm
2018-2023
Université d'Angers
2018-2023
Centre National de la Recherche Scientifique
2018-2023
Centre Hospitalier Universitaire d'Angers
2018-2023
Hôpital Laennec
2021
Institut des Sciences et Technologies Moléculaires d'Angers
2021
Abstract Background The dysfunction of OPA1, a dynamin GTPase involved in mitochondrial fusion, is responsible for large spectrum neurological disorders, each which includes optic neuropathy. database dedicated to OPA1 ( https://www.lovd.nl/OPA1 ), created 2005 , has now evolved towards centralized and more reliable using the Global Variome shared Leiden Open-source Variation Database (LOVD) installation. Results updated database, registers all patients from our center as well those reported...
Abstract Elevated plasma vitamin B12 has been associated with solid cancers, based on a single measurement. We evaluated the incidence of cancers following measurement in patients persistent elevated B12, compared to without and non-persistent . The study population included at least two measurements already known elevated-B12-related causes. Patients (≥ 1000 ng/L) first (n = 344) were matched for age sex having 2 normal (< (NN group, n 344). split into groups, according presence (EE 144)...
VEXAS syndrome is a newly described autoinflammatory disease associated with
(1) Background: Intrauterine growth restriction (IUGR) involves metabolic changes that may be responsible for an increased risk of and cardiovascular diseases in adulthood. Several metabolomic profiles have been reported maternal blood urine, amniotic fluid, cord newborn but the placenta has poorly studied so far. (2) Methods: To decipher origin this reprogramming, we conducted a targeted metabolomics study replicated two cohorts one cohort by measuring 188 metabolites mass spectrometry. (3)...
Serum protein electrophoresis (SPE) is a common clinical laboratory test, mainly indicated for the diagnosis and follow-up of monoclonal gammopathies. A time-consuming potentially subjective human expertise required SPE analysis to detect possible pitfalls provide clinically relevant interpretation.An expert-annotated dataset 159 969 entries was used develop SPECTR (serum computer-assisted recognition), deep learning-based artificial intelligence, which analyzes interprets raw curves...
Abstract Metabolomic studies have demonstrated the existence of biological signatures in blood patients with arterial hypertension, but no study has hitherto reported sexual dimorphism these signatures. We compared plasma metabolomic profiles 28 individuals (13 women and 15 men) essential hypertension those a healthy control group (18 18 men), using targeted metabolomics. Among 188 metabolites explored, 152 were accurately measured. Supervised OPLS-DA (orthogonal partial least...
Sole measurement of plasma vitamin B12 is no longer enough to identify (B12) deficiency. When in the low-normal range, especially between 201 and 350 ng/L, deficiency should be assessed by measurements homocysteine and/or methylmalonic acid (MMA). However, these biomarkers also accumulate during renal impairment, leading a decreased specificity for In such cases, urinary acid/creatinine ratio (uMMA/C) could interest, due stable excretion MMA. The objectives were evaluate influence impairment...
Intrauterine Growth Restriction (IUGR) affects 8% of newborns and increases morbidity mortality for the offspring even during later stages life. Single omics studies have evidenced epigenetic, genetic, metabolic alterations in IUGR, but pathogenic mechanisms as a whole are not being fully understood. An in-depth strategy combining methylomics transcriptomics analyses was performed on 36 placenta samples case-control study. Data-mining algorithms were used to combine analysis more than 1,200...
Few data-driven metabolomic approaches have been reported in sickle cell disease (SCD) to date. We performed a metabo-lipidomic study on the plasma and red blood cells of steady-state mouse model carrying homozygous human hemoglobin SS, compared with AS AA genotypes. Among 188 metabolites analyzed by targeted quantitative approach, 153 129 were accurately measured cells, respectively. Unsupervised PCAs (principal component analyses) gave good spontaneous discrimination between HbSS controls,...
The postmortem diagnosis of hypothermia fatalities is often complex due to the absence pathognomonic lesions and biomarkers. In this study, potential novel biomarkers were searched in vitreous humor known cases (n = 20) compared control 16), using a targeted metabolomics approach allowing quantitative detection 188 metabolites. A robust discriminant model with good predictivity was obtained supervised OPLS-DA multivariate analysis, showing distinct separation between groups. This signature...
Descriptive and retrospective studies without control groups have suggested a possible association between primary Sjögren’s syndrome (pSS) vitamin B12 (B12) deficiency. This is of importance because several mucosal neurological features are common to these two conditions could be prevented or reversed in case We aimed evaluate the pSS prospectively assessed status 490 patients hospitalized an internal medicine department over 15-week period. Patients with pernicious anemia were excluded....
Abstract Background For the detection of cardiac surgery-associated acute kidney injury (CS-AKI), performance urine tissue inhibitor metalloproteinase 2 insulin-like growth factor-binding protein 7 (TIMP2 IGFBP7) has never been compared with that very early changes in plasma creatinine (∆pCr). We hypothesized that, context perioperative haemodilution, lack postoperative decrease pCr would be honourable for CS-AKI. therefore aimed at comparing these biomarkers and their kinetics (primary...
Introduction Assessing labial salivary gland exocrinopathy is a cornerstone in primary Sjögren’s syndrome. Currently this relies on the histopathologic diagnosis of focal lymphocytic sialadenitis and computing focus score by counting lym=phocyte foci. However, those lesions represent advanced stages syndrome, although earlier recognition syndrome its effective treatment could prevent irreversible damage to gland. This study aimed at finding early biomarkers combining metabolomics...
Summary Background Diagnosing iron deficiency is challenging in the presence of systemic inflammation. Aim To investigate relationship between plasma C-reactive protein (CRP), serum ferritin (SF) and transferrin saturation (TS), with objective establishing a straightforward ratio applicable inflammatory syndrome. Design Test prospective cohort validation retrospective cohort. Methods A inpatients (n = 140) assessed correlation CRP SF/TS levels. The diagnostic performance determined was...
Abstract Introduction Several studies have provided evidence of the key role neutrophils in pathophysiology Alzheimer's disease (AD). Yet, no study to date has investigated potential link between AD and morphologically abnormal on blood smears. Methods Due complexity subjectivity task by human analysis, deep learning models were trained predict from neutrophil images. Control for a known feasible (leukocyte subtype classification) detecting biases overfitting (patient prediction). Results...