A5035754619- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Otitis Media and Relapsing Polychondritis
- Folate and B Vitamins Research
- Urticaria and Related Conditions
- Immunodeficiency and Autoimmune Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Platelet Disorders and Treatments
- Autoimmune and Inflammatory Disorders Research
- Autoimmune Bullous Skin Diseases
- Systemic Sclerosis and Related Diseases
- Vascular Anomalies and Treatments
- Parvovirus B19 Infection Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- Blood disorders and treatments
- Ocular Surface and Contact Lens
- Iron Metabolism and Disorders
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Growth Hormone and Insulin-like Growth Factors
- Pancreatitis Pathology and Treatment
Hôpital Beau-Séjour
2025
Centre Hospitalier Universitaire d'Angers
2015-2024
University Hospital of Geneva
2024
Université d'Angers
2015-2024
Centre National de la Recherche Scientifique
2018-2024
Inserm
2012-2024
University of California, San Francisco
2023-2024
Clinique Saint-Joseph
2023
Université Paris Cité
2022
Centre de Recherche Épidémiologie et Statistique
2022
Objective Data on adult IgA vasculitis (Henoch‐Schönlein) (IgAV) are scarce. This survey was designed to better define the clinical spectrum of IgAV and efficacy treatments in a French patient population. Methods characteristics, histologic features, treatment response from 260 patients with included multicenter retrospective were analyzed. Efficacy data compared using different statistical models. Results The mean ± SD age at diagnosis 50.1 18 years, 63% male. Baseline manifestations...
Post-COVID-19 syndrome (PCS) shares many features with myalgic encephalomyelitis/chronic fatigue (ME/CFS). PCS represents a major health issue worldwide because it severely impacts patients' work activities and their quality of life. In the absence treatment for both conditions given beneficial effect pacing strategies in ME/CFS, we conducted this study to assess effectiveness patients.We retrospectively included patients meeting World Health Organization definition who attended Internal...
Introduction The long-term risk of first thrombosis and benefit prophylaxis in antiphospholipid antibody (aPL) carriers without history or obstetrical morbidity is poorly known. This study aimed to evaluate the rate factors associated with a those patients. Patients methods After prior ended December 2005 was already published, we extended follow-up period our cohort aPL carriers. Results Ninety-eight 103 patients previous were included. annual 2.3% per patient-year during median 13 years...
To determine whether hydroxychloroquine decreases the risk of adverse outcome in patients with mild to moderate coronavirus disease 2019 (COVID-19) at high worsening.We conducted a multicentre randomized double-blind placebo-controlled trial evaluating COVID-19 least one following factors for worsening: need supplemental oxygen, age ≥75 years, between 60 and 74 years presence co-morbidity. Severely ill requiring oxygen therapy >3 L/min or intensive care were excluded. Eligible 1:1 ratio...
Abstract Elevated plasma vitamin B12 has been associated with solid cancers, based on a single measurement. We evaluated the incidence of cancers following measurement in patients persistent elevated B12, compared to without and non-persistent . The study population included at least two measurements already known elevated-B12-related causes. Patients (≥ 1000 ng/L) first (n = 344) were matched for age sex having 2 normal (< (NN group, n 344). split into groups, according presence (EE 144)...
Abstract Background Giant cell arteritis (GCA) is frequently associated with aortic involvement that likely to cause life-threatening structural complications (aneurysm, dissection). Few studies have investigated the occurrence of these complications, and no predictive factor has been identified so far. The aim this study was investigate factors risk in a cohort GCA aortitis. Methods Data all patients managed aortitis (CT or 18 FDG PET) at diagnosis five hospitals from May 1998 April 2019...
To describe the clinical presentation, treatments and prognosis of gastrointestinal (GI) involvement in adult IgA vasculitis (IgAV).Data from 260 adults with IgAV included a French multicentre retrospective survey were analysed. Presentation outcomes patients (GI+) without (GI-) GI compared.One hundred thirty-seven (53%) had involvement. Initial manifestations abdominal pain 99%, intestinal bleeding 31%, diarrhoea 26% acute surgical abdomen only 4%. Abdominal imaging revealed thickening wall...
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Introduction Antiphospholipid syndrome (APS) is an autoimmune disease characterised by thrombosis (arterial, venous or small vessel) obstetrical events and persistent antiphospholipid antibodies (aPL), according to the Sydney classification criteria. Many studies have performed cluster analyses among patients with primary APS associated disease, but none has focused solely on APS. We aimed perform a analysis asymptomatic aPL carriers without any assess prognostic value. Methods In this...
VEXAS syndrome is a newly described autoinflammatory disease associated with
The contribution of genetic factors to the severity adult haemophagocytic lymphohistiocytosis (HLHa) remains unclear. To assess a potential link between HLHa outcomes and HLH-related gene variants. Clinical characteristics 130 patients with (age≥18 years old “HScore”≥169) genotype eight genes (LYST, PRF1, UNC13-D, STX11, STXBP2, RAB27A, XIAP SAP) were collected. A total 34 variants found in only six selected based on their frequency criteria predicted impair protein function. Severity was...
Objective To compare characteristics, pregnancies and treatments during of seronegative seropositive antiphospholipid syndrome (APS), to analyse factors associated with obstetrical outcome. Patients methods Inclusion criteria were: (1) thrombotic and/or APS (Sydney criteria); (2) absence conventional antibodies (APL); (3) at least one persistent non-conventional APL among IgA anticardiolipin antibodies, anti-B2GPI, anti-vimentin G/M, anti-annexin V anti-phosphatidylethanolamine G/M...
Objective We aimed to investigate whether anakinra, an interleukin-1receptor inhibitor, could improve outcome in moderate COVID-19 patients. Methods In this controlled, open-label trial, we enrolled adults with requiring oxygen. randomly assigned patients receive intravenous anakinra plus optimized standard of care (oSOC) vs. oSOC alone. The primary was treatment success at day 14 defined as patient alive and not mechanical ventilation or extracorporeal membrane oxygenation. Results Between...
Abstract Sjögren’s disease (SjD) is a heterogeneous autoimmune disorder with significant clinical and molecular diversity. While anti-SSA antibodies serve as hallmark serological biomarker, nearly half of patients lack them, raising fundamental questions about distinct pathogenic mechanisms. To address this, we performed single-cell RNA sequencing surface protein profiling on 1.5 million PBMCs from 333 participants in the International Collaborative Clinical Alliance cohort, comparing those...
The association between elevated plasma vitamin B12 (B12) level and solid cancers has been documented by two national registries. However, their design did not allow for the adjustment other conditions associated with B12. objectives of this study were to confirm after all causes B12, variations according increasing level, type cancers, presence metastases. We compared 785 patients ≥ 1000 ng/L controls matched sex age < ng/L. Analyses adjusted B12: myeloid blood malignancies, acute or...
Abstract Background Unstimulated whole saliva (UWS) flow rate is one of the ACR/EULAR 2016 criteria for primary Sjögren’s syndrome (pSS). With a single threshold ≤ 0.1 mL/min, UWS does not take into account age- and sex-related physiological variations. Furthermore, it has low sensitivity diagnosis pSS (about 50%), contrary to screening test xerophthalmia, Schirmer’s (sensitivity about 70%). We aimed identify thresholds allowing better performances comparable test, considering Methods A...