A5002485469- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods in Clinical Trials
- Statistical Methods and Bayesian Inference
- Advanced Causal Inference Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vascular Malformations and Hemangiomas
- Statistical Methods and Inference
- Polyomavirus and related diseases
- Breast Implant and Reconstruction
- Breast Cancer Treatment Studies
- Systemic Sclerosis and Related Diseases
- Tumors and Oncological Cases
- Physical Activity and Health
- Cutaneous Melanoma Detection and Management
- Respiratory Support and Mechanisms
- Reconstructive Surgery and Microvascular Techniques
- Cardiovascular and Diving-Related Complications
- Full-Duplex Wireless Communications
- Obesity, Physical Activity, Diet
- Reliability and Agreement in Measurement
- Traumatic Brain Injury Research
- Delphi Technique in Research
- Urticaria and Related Conditions
- Healthcare Systems and Practices
Inserm
2016-2025
Centre Hospitalier Universitaire de Tours
2016-2025
Université de Tours
2016-2025
Nantes Université
2018-2025
Clinical Investigation Center Plurithematic Tours
2016-2025
Sciences, Philosophie, Histoire
2016-2025
Adaptation Biologique et Vieillissement
2016-2024
Sorbonne Université
2022-2023
Institut Pierre Louis d‘Épidémiologie et de Santé Publique
2022-2023
Assistance Publique – Hôpitaux de Paris
2022-2023
The management of prosthetic joint infection usually consists a combination surgery and antimicrobial therapy. appropriate duration therapy for this indication remains unclear.
Background Standard of care for interstitial lung disease (ILD) with a nonspecific pneumonia (NSIP) pattern proposes mycophenolate mofetil (MMF) as one the first-step therapies while rituximab is used rescue therapy. Methods In randomised, double-blind, two-parallel group, placebo-controlled trial ( NCT02990286 ), patients connective tissue disease-associated ILD or idiopathic (with without autoimmune features) and NSIP (defined on pathological integration clinicobiological data NSIP-like...
There is an unmet need to identify markers predictive of response ipilimumab in patients with melanoma because the number responders low and its cost very high. An increase absolute lymphocyte count (ALC) or neutrophil/lymphocyte ratio (NLR) just before third infusion has been reported be associated better overall survival (OS). Our aim was determine whether NLR measured first OS. Data were collected on a consecutive series 58 treated four hospitals, including 51 at stage M1c M1b. The...
We sought to determine the prevalence of and factors associated with acute cor pulmonale (ACP) patent foramen ovale (PFO) at early phase respiratory distress syndrome (ARDS), assess their relation mortality.In this prospective multicenter study, 200 patients submitted protective ventilation for moderate severe ARDS [PaO₂/F(I)O₂: 115 ± 39 F(I)O₂: 1; positive end-expiratory pressure (PEEP): 10.6 3.1 cmH2O] underwent transthoracic (TTE) transesophageal echocardiography (TEE) <48 h after...
Little is known concerning mortality and predictive factors for anorexia nervosa in-patients. This study aimed to establish rates identify predictors in a large sample of adults through 10-year post in-patient treatment follow-up.Vital status was established 601 (DSM-IV) consecutive in-patients with initial evaluation at admission. Standardized ratio (SMR) calculated. Cox analyses hypothesized were performed.Forty deaths recorded. SMR 10.6 [CI 95% (7.6-14.4)]. Six admission associated death:...
Background Physical activity is a major component of healthy lifestyle in youth and adults. To identify determinants this complex behavior an important research objective the process designing interventions to promote physical at population level. In addition individual determinants, there evidence documenting familial influences on activity. However, few studies that have addressed issue with measures did not provide data parent-offspring relationships throughout childhood adolescence. The...
Abstract Background The risk of mortality remains unclear for bulimia nervosa (BN) patients, especially the most severe. aims this study were to improve knowledge on BN and mortality. Methods With initial evaluation at admission, 258 (Diagnostic Statistical Manual Mental Disorders, Fourth Edition) consecutive inpatients included (1988–2004). Vital status was established from French national register. Standardized Mortality Ratio (SMR) calculation bivariate Cox analysis performed hypothesised...
Cluster randomised trials can be at risk of bias when participants are identified and recruited after randomisation Reports cluster often fail to adequately describe the recruitment process whether trial staff blinded allocation status key stages This article presents a graphical tool depicting time sequence blinding different together with examples help researchers storyline such Our should used both protocol report-writing clarify identify StandfirstRobust evidence effectiveness...
The use of cluster randomized trial design to answer research questions is increasing. This and associated variants such as the crossover stepped wedge are useful assess complex interventions in a pragmatic way but when adopting designs, one may face specific implementation challenges. article summarizes common challenges faced conducting trials, provides recommendations.
Background: Increasing physical activity and decreasing sedentary time are cornerstones in the management of type 2 diabetes (T2DM). However, there few instruments available to measure this population. We translated long version International Physical Activity Questionnaire (IPAQ-L) into French studied its reproducibility validity patients with T2DM. Methods: Reproducibility was by telephone administrations, 8 days apart. Concurrent tested against pedometry for 7 during habitual life....
Acute cor pulmonale (ACP) and patent foramen ovale (PFO) remain common in patients under protective ventilation for acute respiratory distress syndrome (ARDS). We sought to describe the hemodynamic profile associated with either ACP or PFO, both, during early course of moderate-to-severe ARDS using echocardiography.In this 32-month prospective multicenter study, 195 were assessed echocardiography first 48 h admission (age: 56 (SD: 15) years; Simplified Physiology Score: 46 (17); PaO2/FiO2:...
<b><i>Background/Aims:</i></b> Merkel cell carcinoma (MCC) is a rare high-grade neuroendocrine tumour of the skin. It has been speculated that MCCs express somatostatin receptors (SSTRs), but this never assessed in large series MCCs. The main aim study was to assess expression SSTR2A and SSTR5 MCC tumours. secondary aims were whether SSTR associated with Ki67 proliferative index, polyomavirus (MCPyV) status, clinical characteristics outcome....
Introduction Postoperative wound seroma is common after mastectomy. This complication associated with significant impact on patient outcomes and healthcare costs. The optimal closure approach for prevention remains unknown but some evidence suggests that quilting suture of the dead space could lower incidence seroma. aim this trial to compare formation using versus conventional drainage in patients undergoing Methods analysis a multicentre, superiority, randomised controlled women mastectomy...
Anaplastic gangliogliomas (GGGs) are rare tumors whose natural history is poorly documented. We aimed to define their clinical and imaging features identify prognostic factors. Consecutive cases of anaplastic GGGs in adults prospectively entered into the French Brain Tumor Database between March 2004 April 2014 were screened. After diagnosis was confirmed by pathological review, clinical, imaging, therapeutic, outcome data collected retrospectively. Forty-three patients with GGG (median age,...
Abstract Background Pragmatic trials aim to generate evidence directly inform patient, caregiver and health-system manager policies decisions. Heterogeneity in patient characteristics contributes heterogeneity their response the intervention. However, there are many other sources of outcomes. Based on expertise judgements authors, we identify different clinical methodological heterogeneity, which translate into responses—some consider as desirable some undesirable. For each them, discuss...
Objective We aimed to investigate whether anakinra, an interleukin-1receptor inhibitor, could improve outcome in moderate COVID-19 patients. Methods In this controlled, open-label trial, we enrolled adults with requiring oxygen. randomly assigned patients receive intravenous anakinra plus optimized standard of care (oSOC) vs. oSOC alone. The primary was treatment success at day 14 defined as patient alive and not mechanical ventilation or extracorporeal membrane oxygenation. Results Between...
Abstract Background Guidance exists to inform the content of statistical analysis plans in clinical trials. Though not explicitly stated, this guidance is generally focused on trials which randomization units are individual patients and groups patients. There critical considerations for cluster randomized trials, such as accounting clustering, risk imbalances between arms due post-randomization recruitment, need use small sample corrections when number clusters small. Methods This paper...
Despite the increasing use of medical photography by dermatologists, no study on patients' perceptions in dermatology has been performed to date.Firstly, evaluate photography. Secondly, assess whether differed between patients our adult department and parents accompanying a child paediatric department.An opinion survey was conducted at Hospital Tours (France) among (adult department) (paediatric completion questionnaire after any had performed.We collected 272 questionnaires regarding 158...
Cluster randomized trials (CRTs) are often prone to selection bias despite randomization. Using a simulation study, we investigated the use of propensity score (PS) based methods in estimating treatment effects CRTs with when outcome is quantitative. Of four PS-based (adjustment on PS, inverse weighting, stratification, and optimal full matching method), three successfully corrected bias, as did an approach using classical multivariable regression. However, they showed poorer statistical...
Abstract Despite randomization, selection bias may occur in cluster randomized trials. Classical multivariable regression usually allows for adjusting treatment effect estimates with unbalanced covariates. However, binary outcomes low incidence, such a method fail because of separation problems. This simulation study focused on the performance propensity score (PS)‐based methods to estimate relative risks from trials incidence. The results suggested that among different approaches used...