A5056272367- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Drug-Induced Adverse Reactions
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Ocular Disorders and Treatments
- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Contact Dermatitis and Allergies
- Ophthalmology and Eye Disorders
- Vascular Malformations Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Angiogenesis and VEGF in Cancer
- Mesenchymal stem cell research
- Legionella and Acanthamoeba research
- Anesthesia and Pain Management
- Herpesvirus Infections and Treatments
- Facial Trauma and Fracture Management
- Traumatic Ocular and Foreign Body Injuries
Hôpital Charles-Nicolle
2016-2025
Université de Rouen Normandie
2016-2025
Centre Hospitalier Universitaire de Rouen
2014-2024
Université de Reims Champagne-Ardenne
2024
Centre Hospitalier Universitaire de Reims
2024
Hôpital Charles-Nicolle
1997-2021
Physiopathologie, autoimmunité, maladies neuromusculaire et thérapie régénératrice
2017-2020
Physiopathologie et Epidémiologie des Maladies Respiratoires
2017-2020
Hôpital Bretonneau
2020
Centre Hospitalier Universitaire de Tours
2020
<h3>Objectives</h3> To describe the acute and late ocular manifestations of toxic epidermal necrosis (TEN), Stevens-Johnson syndrome (SJS), overlap to identify predictors for development complications. <h3>Design</h3> Retrospective cohort study. <h3>Setting</h3> A single referral unit in a university hospital. <h3>Patients</h3> The study included 159 patients (mean [SD] age, 49.9 [19.8] years) with TEN SJS during an 8-year period. Forty-nine were contacted at least 15 months after hospital...
Neurotrophic keratopathy is a degenerative disease of the corneal epithelium resulting from impaired innervation, possibly leading to perforation. We aimed assess efficacy and tolerance new matrix therapy agent (RGTA, Cacicol20), mimicking heparan sulfates, for management neurotrophic keratopathy.We carried out an uncontrolled, prospective, single-center clinical study on 11 patients (11 eyes) with severe ulcers, despite use preservative-free artificial tears, 15 days. Patients were treated...
Objectives. Several paradoxical adverse events (PAEs), e.g. IBDs, acute anterior uveitis (AAU) and psoriasis, have been described in patients taking anti-TNF drugs. This retrospective study aimed to describe the different PAEs that occurred a population of SpA treated with drugs, determine whether they are drug specific. Methods. Since 2000, we followed 296 [198 AS, 21 associated IBD (9 ulcerative colitis, 12 Crohn's disease) 77 psoriatic arthritis] at least one (infliximab, etanercept or...
<h3>Aims</h3> The aim of this study was to assess the efficacy and safety pre-Descemet9s membrane (DM) sutures associated with intracameral air injection for management acute corneal hydrops keratoconus. <h3>Methods</h3> We carried out a retrospective interventional seven consecutive cases. Three pre-DM 10-0 nylon were applied perpendicularly tear as close possible DM, under general anaesthesia. An bubble injected into anterior chamber at end each procedure. <h3>Results</h3> Corneal oedema...
Abstract —Neovascularization of the atherosclerotic plaque is responsible for its weakening and consequently complications vascular disease. Macrophages are a source growth factors that can modulate angiogenesis. In this study, we analyzed effect oncostatin M (OSM) on angiogenesis, as it could be involved in development atherosclerosis. The OSM was compared with those leukemia inhibitory factor (LIF) interleukin-6 (IL-6). On human dermal microvasculature endothelial cells (HMEC-1s), (22.5 to...
In Brief Purpose: To determine whether preoperative optical coherence tomography (OCT) is useful in predicting postoperative visual outcome for patients with primary macula-off rhegmatogenous retinal detachment (RD). Methods: This prospective study included 20 nonconsecutive eyes RD and successful reattachment of the retina. Preoperative 5-mm OCT was performed through center fovea. The relationship among findings, main clinical variables, final acuity statistically analyzed. Results: Final...
PURPOSE: We report a novel technique which enables to cut any kind of foldable lens and extract it using capsulorhexis forceps 1.2 mm single-use slit angled knife. METHODS: The consists in the mantain stabilize IOL anterior chamber, while one hand holds that way, second introduces knife through paracenthesis cuts on 3/4 his diameter. is then extracted or twe pieces. RESULTS: Since march 2021 we performed 82 eyes 79 patients. Learning curve was very fast easily managed by two experimented...
Aims/Purpose: Corneal storage in organ culture (OC) at 31‐34°C is the reference method Europe. In France, eye banks have traditionally used CorneaMax/CorneaJet media (Eurobio, Les Ulis, France) for several decades. Recently, Tissue‐C/Carry‐C (Alchimia‐Moria, Antony, became available. This study aims comparing quality of corneas stored these two media. Methods: Eye Saint Etienne and Rouen participated study. Rouen, experiments were conducted. The first included 18 pairs corneas, with...
Purpose: Cyclosporin A (CsA) is a drug used to prevent immune rejection in corneal transplantation. Most grafts performed today are endothelial which complicated with poor penetration of CsA into the endothelium due its hydrophobicity. To improve new ocular formulation 2% Miglyol was developed and commercially available. The purpose this pharmacokinetic study determine concentrations all layers cornea, particular after topical administration 2%-Miglyol rabbits. Methods: Sixteen rabbits were...
To present an experimental method for determining the viable cell pool of corneal endothelia and its application to assessing predissected endothelial grafts.The density (ECD) five pairs human organ cultured corneas was determined using a standard counting with calibrated image analysis system. A thin posterior graft (30-50 μm) manually from cornea chosen at random. Predissected control were shipped remote center, where ECD determination repeated immediately followed by triple...
To evaluate the characterics and surgical prognosis of macular holes that develop after rhegmatogenous retinal detachment repair.Retrospective, interventional, consecutive case series.The records nine patients who developed a new full-thickness hole prior RD repair were reviewed over 6 years. Optical coherence tomography (OCT) confirmed these holes. They offered with median follow-up 13.3 months (1-63 months). Main outcomes included preoperative vitreo-macular status, OCT evaluation...
Purpose: To describe corneal changes visible on in vivo confocal microscopy, patients with debilitating ocular sequelae because of toxic epidermal necrolysis (TEN) or Stevens-Johnson syndrome (SJS). Patients and Methods: Forty-one eyes 25 consecutive suffering from chronic TEN SJS were studied using microscopy. Results: Severe dry eye no associated limbal stem cell deficiency (25 eyes, 16 patients, 61%) was the most frequent clinical pattern. Limbal noted (12 39%). Three had asymmetric...
The objective of this study was to evaluate the ophthalmological outcome, nonvisual morbidity, and surgical complications after tuberculum sellae meningioma (TSM) removal using a superior interhemispheric approach.In last decade, 20 consecutive patients with TSM underwent operations approach. Visual acuity, visual field, ocular fundus examination were assessed both preoperatively 6-months postoperatively. Nonvisual morbidity determined at an early postoperative period 6 months based on...
Purpose: To compare the pupil dynamics of an intracameral combination 2 mydriatics and 1 anesthetic (Mydrane) to a standard topical regimen for cataract surgery. Setting: Sixty-two centers in Europe 6 Algeria. Design: Prospective case series. Methods: Pupil size measurements were performed randomized studies (phase phase 3) under masked conditions (recorded videography, reading center). The outcomes study supported evaluation timeframe obtain dilation 3 provided results on mydriasis...