A5025900636- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Ocular Infections and Treatments
- Allergic Rhinitis and Sensitization
- Autoimmune Bullous Skin Diseases
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Ocular Diseases and Behçet’s Syndrome
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Contact Dermatitis and Allergies
- Acne and Rosacea Treatments and Effects
- Retinal and Optic Conditions
- Vasculitis and related conditions
- Herpesvirus Infections and Treatments
- Dermatology and Skin Diseases
- Drug-Induced Adverse Reactions
- Intraocular Surgery and Lenses
- Cerebral Venous Sinus Thrombosis
- Cytomegalovirus and herpesvirus research
- Olfactory and Sensory Function Studies
- Skin and Cellular Biology Research
- Traumatic Ocular and Foreign Body Injuries
- Skin Protection and Aging
- Facial Rejuvenation and Surgery Techniques
Hôpital Bichat-Claude-Bernard
2015-2024
Fondation de Rothschild
2015-2024
Assistance Publique – Hôpitaux de Paris
2009-2024
Université Paris Cité
2008-2024
ENT and Allergy
2024
Université Claude Bernard Lyon 1
1999-2024
Fondation Ophtalmologique Adolphe de Rothschild
2012-2023
Sorbonne Université
2023
Centre d'Immunologie et des Maladies Infectieuses
2023
Inserm
2023
Mucous membrane pemphigoid (MMP) still represents a potentially life- and sight-threatening disease. In subset of patients with severe MMP, conventional immunosuppressants are ineffective or contraindicated.Twenty-five refractory including 5 mucous membrane-dominant epidermolysis bullosa acquisita, received 1 2 cycles rituximab (375 mg/m(2) weekly for 4 weeks). Twenty-one the were receiving concomitant therapy dapsone and/or sulfasalazine therapy, which was maintained during cycles. Complete...
Susac syndrome is characterized by the clinical triad of encephalopathy, hearing loss, and retinal artery branch occlusions, mostly in young women. To our knowledge, long-term outcome impact pregnancy have not been specifically addressed. We report a series 9 patients (7 female, 2 male) followed at same institution, with special emphasis on including sequelae. Clinical, brain magnetic resonance imaging (MRI), funduscopy, angiography, audiogram data were recorded every 3-12 months. also...
<h3>Objective:</h3> To determine the prevalence of vernal keratoconjuntivitis (VKC) in Europe. <h3>Methods:</h3> A cross-sectional survey was mailed to 3003 ophthalmologists from six countries (Finland, France, Italy, The Netherlands, Norway and Sweden) representing 151.9 million inhabitants. Results were analysed per country, VKC for 15 European member states 2002 extrapolated. Six hypotheses used: disease duration (4 or 8 years) combined with three non-responding ophthalmologists....
To identify differences in corneal hysteresis (CH) and central thickness (CCT) between healthy glaucomatous patients.Retrospective observational study. One hundred thirty-three eyes of 75 58 patients were included. CH was measured each patient using Ocular Response Analyzer. CCT determined by ultrasonic pachymetry. For patient, one eye randomly selected. We used a Student t-test to search for significant the different groups (p<0.05).In eyes, mean values 10.46 +/- 1.6 8.77 1.4 mm Hg,...
<h3>Purpose</h3> Vernal keratoconjunctivitis (VKC) is a chronic, allergic, and potentially severe ocular disease affecting children adolescents that can lead to impaired quality of life (QoL) loss vision. This study evaluated the efficacy safety an investigational therapy for VKC, cyclosporine A (CsA) cationic emulsion (CE), oil-in-water with increased bioavailability versus conventional CsA formulations. <h3>Design</h3> The VErnal KeratoconjunctiviTIs Study (VEKTIS) phase 3, multicenter,...
Although ocular adverse events are frequent in AD patients treated with dupilumab, their characterization remains limited due to a lack of prospective studies systematic ophthalmological examination. To examine the incidence, characteristics and risk factors dupilumab-induced events. A prospective, multicenter, real-life study adult dupilumab. At baseline, 27 out 181 (14.9%) had conjunctivitis. week 16 (W16), 25 improved conjunctivitis 2 remained stable 34 (18.7%) blepharoconjunctivitis:...
Abstract Background Nonreversible hearing loss (HL) is the main sequelae of Susac syndrome (SuS). We aimed to identify risk factors for HL in SuS. Methods The CARESS study a prospective national cohort that started December 2011, including all consecutive patients with SuS referred French reference center. was designed follow‐up fundoscopy, audiometry, and brain magnetic resonance imaging at 1, 3, 6, 12 months after diagnosis then annually 5 years. primary outcome occurrence last severe...
Vernal keratoconjunctivis (VKC) is a severe form of pediatric ocular allergy, characterized by acute and chronic corneoconjunctival inflammation that may lead to visual sequelae. Although topical immunosuppressive drugs such as cyclosporine are usually effective, some forms be refractory require prolonged steroid therapy. Very few papers report the use omalizumab in VKC literature. In present study, we describe our clinical experience with children.We retrospectively reviewed files four boys...
This study compared the efficacy and safety of hyaluronic acid (HA)-trehalose, a new eyedrop containing trehalose (a natural bioprotectant) HA, to an established formulation only HA.This was phase III, randomized, active-controlled, investigator-masked, multicenter in France Tunisia. In all, 105 adult patients (≥18 years) with moderate severe dry eye disease (DED) received either HA-trehalose (n = 52) or HA 53) 3-6 times per day for 84 days. The primary variable Oxford grading score at 35. A...
We conducted a prospective study between 1995 and 2002 to investigate nose throat (NT) manifestations of mucous membrane pemphigoid (MMP). One hundred ten consecutive patients with clinical, histologic, immunologic criteria MMP were seen in 2 referral centers for bullous diseases. They systematically asked about the existence persistent NT symptoms. Patients who had any examined flexible nasopharyngolaryngoscope by same otorhinolaryngologist. When possible, (MM) biopsies taken direct...
The purpose of this study is to report the efficacy azithromycin 1.5% eye drops in children with ocular rosacea and phlyctenular blepharokeratoconjunctivitis. This retrospective from January 2009 March 2010 included 16 treated lid hygiene plus (Azyter®): 3-day treatments (1 drop twice a day) every 10 days, reduced based on one treatment 15 days then per month.Nineteen eyes six boys ten girls, aged 4 years (mean, 9.3 ± 4.0) were included. disease was previously resistant (all patients), oral...
Mucous membrane pemphigoid (MMP) still represents a potentially life- and sight-threatening disease. Immunosuppressants, such as cyclophosphamide (CYC), are indicated for patients with severe and/or refractory MMP.To evaluate the efficacy safety of daily oral CYC without corticosteroids therapy MMP.Thirteen MMP, who received at an initial dose 2 mg kg(-1) corticosteroids, were retained. Previous treatments, example dapsone, sulfasalazine or topical agents, maintained during treatment....
To assess the safety and efficacy of cyclosporine A cationic emulsion (CsA CE) 0.1% eye drops in pediatric patients with severe active vernal keratoconjunctivitis (VKC).Multicenter, double-masked, randomized controlled trial 8-month analysis.Of 169 (age range, 4-17 years) initially 4-month VErnal KeratoconjunctiviTIs Study (VEKTIS), 142 entered follow-up period during which CsA CE remained on their original regimen 4 times daily [QID, high-dose] or twice [BID, low-dose] + vehicle BID) were...
Abstract Allergic asthma (AA) is a common phenotype, and its diagnosis requires both the demonstration of IgE‐sensitization to aeroallergens causative role this sensitization as major driver symptoms. Therefore, bronchial allergen challenge (BAC) would be occasionally required identify AA patients among atopic asthmatics. Nevertheless, BAC usually considered research tool only, with existing protocols being tailored mild asthmatics needs (eg long washout period for inhaled corticosteroids)....