A5002044752- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- COVID-19 and healthcare impacts
- Sinusitis and nasal conditions
- School Health and Nursing Education
- Ethics and Legal Issues in Pediatric Healthcare
- Telemedicine and Telehealth Implementation
- Delphi Technique in Research
- Pharmaceutical studies and practices
- Microscopic Colitis
- Receptor Mechanisms and Signaling
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Disorders and Syndromes
- Immune responses and vaccinations
- Neuroscience of respiration and sleep
- Pediatric health and respiratory diseases
Università Cattolica del Sacro Cuore
2017-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2025
Agostino Gemelli University Polyclinic
2018-2024
Imperial College London
2023
Guy's and St Thomas' NHS Foundation Trust
2021-2022
University of the Sacred Heart
2020
Royal Brompton Hospital
2018
Sapienza University of Rome
2014
Objective: The upcoming introduction of mepolizumab represents a promising treatment for chronic rhinosinusitis with nasal polyps (CRSwNP). present study aimed to evaluate the effectiveness on sinonasal outcomes comorbid CRSwNP and severe asthma in real-life setting. primary endpoint was changes SinoNasal Outcome Test (SNOT)-22 score, Nasal Polyp (NP) blood eosinophil count during 12-month mepolizumab. Secondary endpoints were quantify mepolizumab’s effects mentioned parameters, identify...
Abstract Allergic asthma (AA) is a common phenotype, and its diagnosis requires both the demonstration of IgE‐sensitization to aeroallergens causative role this sensitization as major driver symptoms. Therefore, bronchial allergen challenge (BAC) would be occasionally required identify AA patients among atopic asthmatics. Nevertheless, BAC usually considered research tool only, with existing protocols being tailored mild asthmatics needs (eg long washout period for inhaled corticosteroids)....
Background/Objectives: Benralizumab is a monoclonal antibody that targets the interleukin-5 receptor (IL-5Rα), leading to rapid depletion of blood eosinophils. RCTs have demonstrated efficacy in patients with severe eosinophilic asthma (SEA). The aim this study was assess benralizumab on sinonasal outcomes real-life setting SEA and concomitant chronic rhinosinusitis nasal polyps (CRSwNP). Methods: We included 25 (mean age: 57.47 years, range: 35–77, F/M = 12:13) who were prescribed 30 mg...
Mepolizumab represents an effective strategy for severe eosinophilic asthma. Small airways disease (SAD) defines a peculiar asthma phenotype related to worse control. Limited and indirect findings are currently available on the effect of mepolizumab SAD. Objectives: We investigated impact SAD assessed through impulse oscillometry (IOS) spirometry. As secondary outcomes, we tested correlation between clinical, functional inflammatory parameters. Methods: This is prospective cohort study...
Celiac disease (CD) is an autoimmune disorder triggered by the ingestion of gluten. Serology and organ culture system can support CD diagnosis, despite histology being gold standard.We wanted to test uniformity application Marsh-Oberhuber criteria five different histologists. We also compared histological serological data with cultural results consider new possible strategies in diagnosis.We studied 114 patients, who were divided two groups. Group A was composed 66 patients on a...
Abstract Efficacious, effective and efficient communication between healthcare professionals (HCP) patients is essential to achieve a successful therapeutic alliance. Telemedicine (TM) has been used for decades but during the COVID‐19 pandemic its use become widespread. This position paper aims describe terminology most important forms of TM among HCP review existing studies on uses asthma allergy. Besides, advantages risks are discussed, concluding that application reduces costs time both,...
The restrictions imposed by the COVID-19 pandemic impact heavily management of chronic diseases like asthma. This study aimed to evaluate adults and children with asthma during COVID-19-related lockdown.A survey was launched European Academy Allergy Clinical Immunology (EAACI) via e-mail, website, social media EAACI members peer societies.The completed 339 healthcare professionals from 52 countries. 79% follow-up consultations were replaced phone calls, whereas 49% newly referred patients...
Abstract Background and objective A proportion of patients with fibrotic hypersensitivity pneumonitis (fHP) follow a progressive disease course despite immunosuppressive treatment. Little is known about predictors mortality in fHP. We aimed to investigate the impact short‐term lung function changes fHP on mortality. Methods Baseline demographics for 145 consecutive multi‐disciplinary team diagnosis fHP, as well baseline 1‐year follow‐up function, echocardiographic findings, bronchoalveolar...
Microbiota composition and associated metabolic activities are essential for the education development of a healthy immune system. Microbial dysbiosis, caused by risk factors such as diet, birth mode, or early infant antimicrobial therapy, is with inception allergic diseases. In turn, diseases increase irrational use therapy. therapies, probiotics, have been studied in prevention treatment diseases, but evidence remains limited due to studies high heterogeneity, strain-dependent...
Abstract Introduction Guidelines recommend treating asthma exacerbations (AAEs) with bronchodilators combined inhaled and/or systemic corticosteroids. Indications for antibiotic prescriptions AAEs are usually not incorporated although the literature shows antibiotics frequently prescribed. Aim To investigate prescription rates in and explore possible determining factors of those practices. Methods A digital survey was created to determine influencing The distributed among European academy...
<b>Background:</b> Hypersensitivity pneumonitis (HP) varies in widely behaviour, from self-limiting disease to inexorably progressive lung scarring. Given its unpredictability, we set out assess whether short term changes function could identify patients at risk. <b>Methods:</b> Consecutive adult with hypersensitivity attending the RBH ILD clinic and performing PFTs according ATS guidelines, seen between 2011 2014 least one follow up test were considered eligible. <b>Results:</b> 205...
In December 2019, China reported the first cases of coronavirus disease 2019 (COVID-19). This disease, caused by severe acute respiratory syndrome-related 2 (SARS-CoV-2), has developed into a pandemic. To date it resulted in ~5.6 million confirmed and 353,334 related deaths worldwide. Unequivocally, COVID-19 pandemic is gravest health socio-economic crisis our time. this context, numerous questions have emerged demand basic scientific information evidence-based medical advice on SARS-CoV-2...
<b>Aim and objectives:</b> Small Airway Disease (SAD) has gained relevance being this related to an asthma phenotype characterized by a higher degree of severity, worse symptom control increased risk exacerbations. Impulse Oscillometry (IOS) is the Gold Standard directly assess periphery lungs, with R5-R20 >0.07 supportive SAD. Mepolizumab represents effective strategy for severe eosinophilic asthma, however, limited evidence available about its benefits on First, we aimed whether SAD may...
Introduction Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences mechanisms and response to treatments. The Paediatric Asthma Real Life (PeARL) Think Tank aspires develop the best available evidence children. An overview of systematic reviews (SRs) paediatric maintenance management an SR treatments acute attacks children, requiring emergency presentation with/without hospital admission will be...