Sanna Toppila‐Salmi
A5106314015- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- Nasal Surgery and Airway Studies
- Respiratory and Cough-Related Research
- Head and Neck Surgical Oncology
- Dermatology and Skin Diseases
- Health and Medical Studies
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cell Adhesion Molecules Research
- Food Allergy and Anaphylaxis Research
- IL-33, ST2, and ILC Pathways
- Research in Social Sciences
- Inhalation and Respiratory Drug Delivery
- Tryptophan and brain disorders
- Air Quality and Health Impacts
- Contact Dermatitis and Allergies
- Immune Response and Inflammation
- Olfactory and Sensory Function Studies
- Tracheal and airway disorders
- Cancer Immunotherapy and Biomarkers
- Occupational exposure and asthma
- Glycosylation and Glycoproteins Research
- Drug-Induced Adverse Reactions
University of Helsinki
2016-2025
Helsinki University Hospital
2016-2025
University of Eastern Finland
2023-2025
Kuopio University Hospital
2023-2025
Taipei City Government
2024
Temple University
2024
American Academy of Otolaryngology — Head and Neck Surgery
2024
Harvard University
2024
Hospital District of Helsinki and Uusimaa
2012-2024
Institute for Molecular Medicine Finland
2023
The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 2007 2012(1-3). core objective EPOS2020 guideline to provide revised, up-to-date clear evidence-based recommendations integrated care pathways ARS CRS. provides an literature studies undertaken eight years since EPOS2012 paper was addresses areas not extensively covered such as paediatric CRS sinus surgery. also involves new stakeholders, including...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry starts with membrane attachment and ends spike (S) protein–catalyzed fusion depending on two cleavage steps, namely, one usually by furin in producing cells the second TMPRSS2 target cells. Endosomal cathepsins can carry out both. Using real-time three-dimensional single-virion tracking, we show that genome penetration require virion exposure to an acidic milieu of pH 6.2 6.8, even when cleavages have occurred. We detect...
Nasal endoscopy is not only used for the diagnosis of chronic rhinosinusitis with nasal polyps (CRSwNP), but also monitoring response to therapy playing an important role in both daily practice and research. In contrast patient-reported outcomes, endoscopic polyp scoring by independent blinded readers objective measurement, influenced placebo effect. It safer cheaper compared computed tomography imaging therefore, better suited regular assessments extent disease. Since early 90s, a variety...
Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is debilitating disease significant impact on quality life (QoL). With novel knowledge and treatment options becoming available, there growing need to update or revise key definitions enable communication across different specialties dealing agree goals care in CRSwNP. The European Forum for Research Education Allergy Airway diseases (EUFOREA) EPOS expert members discussed how measure...
To cite this article: Videler WJ, Badia L, Harvey RJ, Gane S, Georgalas C, van der Meulen FW, Menger DJ, Lehtonen MT, Toppila‐Salmi SK, Vento SI, Hytönen M, Hellings PW, Kalogjera Lund VJ, Scadding G, Mullol J, Fokkens WJ. Lack of Efficacy long‐term, low‐dose azithromycin in chronic rhinosinusitis: a randomized controlled trial. Allergy 2011; 66 : 1457–1468. Abstract Background: In persistent rhinosinusitis (CRS), conventional treatment is often insufficient. Long‐term, administration...
The coronavirus disease 2019 (COVID-19) has evolved into a pandemic infectious transmitted by the severe acute respiratory syndrome (SARS-CoV-2). Allergists and other healthcare providers (HCPs) in field of allergies associated airway diseases are on front line, taking care patients potentially infected with SARS-CoV-2. Hence, strategies practices to minimize risks infection for both HCPs treated have be developed followed allergy clinics.The scientific information COVID-19 was analysed...
The number of patients affected by allergies is increasing worldwide. resulting allergic diseases are leading to significant costs for health care and social systems. Integrated pathways needed enable comprehensive within the national ARIA (Allergic Rhinitis its Impact on Asthma) initiative develops internationally applicable guidelines respiratory diseases. serves improve with chronic In collaboration other international initiatives, associations patient organizations in field diseases,...
Summary Background Mobile technology may help to better understand the adherence treatment. MASK ‐rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient‐centred ICT system. A mobile phone app (the Allergy Diary) central available in 22 countries. Objectives To assess treatment rhinitis patients using Diary App. Methods An observational cross‐sectional study was carried out on all users who filled from 1 January 2016 August 2017. Secondary assessed by modified...
Validated combined symptom-medication scores (CSMSs) are needed to investigate the effects of allergic rhinitis treatments. This study aimed use real-life data from MASK-air® app generate and validate hypothesis- data-driven CSMSs.We used assess concurrent validity, test-retest reliability responsiveness one hypothesis-driven CSMS (modified CSMS: mCSMS), mixed score (mixed score), several CSMSs. The latter were generated with following cluster analysis regression models or factor analysis....
Chronic rhinosinusitis (CRS) is known to affect around 5 % of the total population, with major impact on quality life those severely affected (1). Despite a substantial burden individuals, society and health economies, CRS often remains underdiagnosed, under-estimated under-treated (2). International guidelines like European Position Paper Rhinosinusitis Nasal Polyps (EPOS) (3) Consensus statement Allergy Rhinology: 2021 (ICAR) (4) offer physicians insight into recommended treatment options...
Co-medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This particularly relevant since AR understood differently across European countries, as reflected by rhinitis-related search in Google Trends. study aims to assess co-medication regional Europe, using real-world data. We analysed 2015-2020 MASK-air® compared days under no medication, monotherapy the visual analogue scale (VAS) levels for overall symptoms ('VAS Global Symptoms')...
MASK-air
Adherence to rhinitis treatment has been insufficiently assessed. We aimed use data from the MASK-air mHealth app assess adherence oral antihistamines (OAH), intra-nasal corticosteroids (INCS) or azelastine-fluticasone in patients with allergic rhinitis. included regular European users self-reported and reporting at least 1 day of OAH, INCS azelastine-fluticasone. assessed weeks during which answered questionnaire on all days. restricted our analyses provided between January June, encompass...