Maria Kokosi
A5030074871- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Pulmonary Hypertension Research and Treatments
- Systemic Sclerosis and Related Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Inflammatory Myopathies and Dermatomyositis
- Pleural and Pulmonary Diseases
- Occupational exposure and asthma
- Eosinophilic Disorders and Syndromes
- Pneumocystis jirovecii pneumonia detection and treatment
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Vasculitis and related conditions
- Vascular Anomalies and Treatments
- Infrared Thermography in Medicine
- Mechanical Circulatory Support Devices
- Medical and Health Sciences Research
- Cardiac Arrhythmias and Treatments
- Venous Thromboembolism Diagnosis and Management
- Tuberous Sclerosis Complex Research
- Sinusitis and nasal conditions
Royal Brompton Hospital
2015-2024
Imperial College London
2018-2024
Royal Brompton & Harefield NHS Foundation Trust
2015-2024
Harefield Hospital
2021-2024
Guy's and St Thomas' NHS Foundation Trust
2019-2024
St Thomas' Hospital
2019-2024
IQVIA (United Kingdom)
2024
Galapagos (Belgium)
2024
Bristol-Myers Squibb (Germany)
2024
Roche (Switzerland)
2024
Introduction Pneumothorax and pneumomediastinum have both been noted to complicate cases of coronavirus disease 2019 (COVID-19) requiring hospital admission. We report the largest case series yet described patients with these pathologies (including nonventilated patients). Methods Cases were collected retrospectively from UK hospitals inclusion criteria limited a diagnosis COVID-19 presence either pneumothorax or pneumomediastinum. Patients included in study presented between March June...
Computer-based computed tomography (CT) analysis can provide objective quantitation of disease in idiopathic pulmonary fibrosis (IPF). A computer algorithm, CALIPER, was compared with conventional CT and function measures severity for mortality prediction.CT variables (forced expiratory volume 1 s, forced vital capacity, diffusion capacity the lung carbon monoxide, transfer coefficient monoxide composite physiologic index (CPI)) 283 consecutive patients a multidisciplinary diagnosis IPF were...
The impact of coronavirus disease (COVID-19) on patients with interstitial lung (ILD) has not been established.
Purpose: The aim of the study was to determine whether a novel computed tomography (CT) postprocessing software technique (CALIPER) is superior visual CT scoring as judged by functional correlations in idiopathic pulmonary fibrosis (IPF). Materials and Methods: A total 283 consecutive patients with IPF had parenchymal patterns evaluated quantitatively CALIPER scoring. These 2 techniques were against: forced expiratory volume 1 second (FEV1), vital capacity (FVC), diffusing for carbon...
Rationale: Quantitative computed tomographic (CT) measures of baseline disease severity might identify patients with idiopathic pulmonary fibrosis (IPF) an increased mortality risk. We evaluated whether quantitative CT variables could act as a cohort enrichment tool in future IPF drug trials.Objectives: To determine computer-derived measures, specifically vessel–related structures (VRSs), can better predict functional decline and survival reduce requisite sample sizes trial...
Rituximab is often used as rescue therapy in interstitial lung disease (ILD) associated with connective tissue (CTD), but has not been studied clinical trials. This study aimed to assess whether rituximab superior cyclophosphamide a treatment for severe or progressive CTD ILD.
We sought to determine the type of pulmonary involvement in microscopic polyangiitis (MPA), primarily focusing on fibrosis (PF), its prevalence, temporal relationship with other disease manifestations and outcome. 33 patients (16 males) biopsy proven perinuclear anti-neutrophilic cytoplasmic antibody-positive MPA (age 63.5 yrs) participated study. Pulmonary was assessed using standard methods, including radiographic imaging (chest radiographs high-resolution computed tomography), function...
The aim of this study was to compare radiology-based prediction models in rheumatoid arthritis-related interstitial lung disease (RAILD) identify patients with a progressive fibrosis phenotype.RAILD had computed tomography (CT) scans scored visually and using CALIPER forced vital capacity (FVC) measurements. Outcomes were evaluated three techniques, as follows. 1) Scleroderma system evaluating visual extent FVC values; 2) Fleischner Society idiopathic pulmonary (IPF) diagnostic guidelines...
This study aimed to investigate whether the combination of fibrosis and emphysema has a greater effect than sum its parts on functional indices outcome in idiopathic pulmonary (IPF), using visual computer-based (CALIPER) computed tomography (CT) analysis. Consecutive patients (n=272) with multidisciplinary IPF diagnosis had extent interstitial lung disease (ILD) scored visually by CALIPER. Visually was subcategorised as isolated or mixed fibrotic lung. The CT scores were evaluated against...
We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group physicians and compared their diagnostic performance to panel IPF experts. A total 1141 respiratory 34 experts participated. Participants evaluated 60 cases interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (κ w ). Prognostic discrimination between other ILDs used validate accuracy for...
<b><i>Background:</i></b> The significance of the nutritional status in idiopathic pulmonary fibrosis (IPF) is largely unknown. Temporal body weight (BW) change, a dynamic index nutrition status, can detect malnutrition more accurately than conventional single-point mass evaluation. <b><i>Objective:</i></b> To investigate how temporal BW change influences clinical courses IPF. <b><i>Methods:</i></b> This multicenter...
To evaluate computer-based computer tomography (CT) analysis (CALIPER) against visual CT scoring and pulmonary function tests (PFTs) when predicting mortality in patients with connective tissue disease-related interstitial lung disease (CTD-ILD). identify outcome differences between distinct CTD-ILD groups derived following automated stratification of CALIPER variables.A total 203 consecutive assorted CTD-ILDs had parenchymal patterns evaluated by scoring: honeycombing, reticular pattern,...
Purpose To investigate the prevalence of diffuse pulmonary ossification (DPO) in patients with fibrosing interstitial lung disease (ILD) and determine whether there are differences among types ILDs. Materials Methods Institutional review board approval was given patient consent not required for this study. The study population comprised 892 consecutive ILD, including 456 idiopathic fibrosis (IPF) (men, 366; women, 90; median age, 72 years [range, 38–93 years]), 244 nonspecific pneumonia 79;...
BACKGROUNDPleuroparenchymal fibroelastosis (PPFE) has been described in hypersensitivity pneumonitis (HP) yet its functional implications are unclear. Combined pulmonary fibrosis and emphysema (CPFE) occasionally never-smokers with HP, but epidemiological data regarding prevalence is sparse. CTs a large HP cohort were therefore examined to identify the effects of PPFE emphysema.Methods233 patients had CT extents interstitial lung disease (ILD) quantified nearest 5%. Lobar percentage pleural...
AimsAutoimmune conditions such as rheumatoid arthritis-related interstitial lung disease (RA-ILD) have been linked to the existence of emphysema in never-smokers. We aimed quantify prevalence RA-ILD never-smokers and investigate whether combined pulmonary fibrosis (CPFE) results a worsened prognosis independent baseline extent.MethodsRA-ILD patients presenting Royal Brompton Hospital (n = 90) Asan Medical Center 155) had CT's evaluated for definite usual pneumonia (UIP) pattern, visual...
Background Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service Scotland June 2021 England, Wales Northern Ireland November 2021. To date, there has been no national evaluation use nintedanib PF-ILD a real-world setting. Methods 26 UK centres were invited to take part service between 17 30 September 2022. Summary data regarding...
Pleuroparenchymal fibroelastosis (PPFE) is now a defined clinicopathologic entity in the updated 2013 ATS/ERS classification of idiopathic interstitial pneumonias (IIPs), which has led to significant increase cases being diagnosed at our institution. We have therefore reviewed 43 PPFE (58 biopsies total) assess whether any clinical or histopathologic features provide prognostic information. A semiquantatitive grading system was used extent fibroblastic foci, intra-alveolar fibroelastosis,...
Chronic hypersensitivity pneumonitis (CHP) has a variable disease course. Computer analysis of CT features was used to identify subset CHP patients with an outcome similar idiopathic pulmonary fibrosis (IPF). Consecutive multi-disciplinary team diagnosis (n = 116) had function tests (FEV1, FVC, DLco, Kco, and composite physiologic index [CPI]) variables predictive mortality evaluated by analysing visual computer-based (CALIPER) parenchymal features: total interstitial lung (ILD) extent,...
ABSTRACT Background and objective This study evaluated whether patients with combined pulmonary fibrosis emphysema (CPFE) have an increased likelihood of hypertension (PHT) when compared idiopathic (IPF) without emphysema. Methods Two consecutive IPF populations having undergone transthoracic echocardiography were examined ( n = 223 162). Emphysema interstitial lung disease (ILD) extent quantified visually; ILD was also by a software tool, CALIPER. Echocardiographic criteria categorized PHT...