A5028207344- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Pleural and Pulmonary Diseases
- Long-Term Effects of COVID-19
- Ultrasound in Clinical Applications
- Zebrafish Biomedical Research Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Intensive Care Unit Cognitive Disorders
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Pneumothorax, Barotrauma, Emphysema
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- Primary Care and Health Outcomes
- Cardiovascular and Diving-Related Complications
- Sarcoidosis and Beryllium Toxicity Research
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Innovations in Medical Education
- Sepsis Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cystic Fibrosis Research Advances
- Systemic Sclerosis and Related Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
University of Exeter
2023-2025
North Bristol NHS Trust
2015-2025
University of Bristol
2015-2025
Royal Devon & Exeter NHS Foundation Trust
2023-2024
Royal United Hospital Bath NHS Trust
2022-2024
University Hospitals Bristol and Weston NHS Foundation Trust
2021-2023
University Hospitals Bristol NHS Foundation Trust
2020-2023
Great Western Hospital
2018-2021
Great Western Hospitals NHS Foundation Trust
2020-2021
Bristol Royal Infirmary
2016
Background There is an emerging understanding that coronavirus disease 2019 (COVID-19) associated with increased incidence of pneumomediastinum (PTM). We aimed to determine its among patients hospitalised COVID-19 in the UK and describe factors outcome. Methods A structured survey PTM was conducted from September 2020 February 2021. UK-wide participation solicited via respiratory research networks. Identified had severe acute syndrome 2 (SARS-CoV-2) infection radiologically proven PTM. The...
Background Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service Scotland June 2021 England, Wales Northern Ireland November 2021. To date, there has been no national evaluation use nintedanib PF-ILD a real-world setting. Methods 26 UK centres were invited to take part service between 17 30 September 2022. Summary data regarding...
Abstract Introduction Growing evidence suggests that biological sex influences the incidence, presentation, diagnosis and outcomes of many lung diseases. Understanding these differences is first step towards precision medicine to improve patient care. Methods IPF patients enrolled in a national, multicentre registry (UK BTS ILD) were categorised by analysed for demographics, pulmonary function tests, HRCT radiological pattern, eligibility/uptake antifibrotics survival. Results Of 7177 cases,...
Following neutralization of infectious threats, neutrophils must be removed from inflammatory sites for normal tissue function to restored. Recently, a new paradigm has emerged, in which viable migrate away by process best described as reverse migration. It generally been assumed that this is the mirror image chemotaxis, where are drawn into areas infection or damage gradients chemotactic cues. Indeed, efforts underway identify cues drive process, fugetaxis. By using photoconvertible...
Neutrophils must be removed from inflammatory sites for inflammation to resolve. Recent work in zebrafish has shown neutrophils can migrate away sites, as well die situ. The signals regulating the process of reverse migration are considerable interest, but remain unknown. We wished study behaviour during migration, see whether they moved inflamed a directed fashion same way recruited or inherent random component their was enough account this behaviour. Using neutrophil-driven...
Bacterial pleural infection requires prompt identification to enable appropriate investigation and treatment. In contrast commonly used biomarkers such as C-reactive protein (CRP) white cell count (WCC), which can be raised due non-infective inflammatory processes, procalcitonin (PCT) has been proposed a specific biomarker of bacterial infection. The utility PCT in this role is yet validated large prospective trial. This study aimed identify whether serum superior CRP WCC establishing the...
Neutrophil function is thought to be regulated, in large part, by limitation of lifespan apoptosis. A number studies suggest that circulating neutrophils have a half-life approximately 6 hours, although contradictory evidence exists. Measuring tissue neutrophil lifespan, however, more problematic. It survive longer, perhaps with the order 3–5 days, but this has never been directly measured. Zebrafish are an emerging model organism, several advantages for study vertebrate immunity. In...
<b><i>Background:</i></b> Haematological malignancy is an important cause of pleural effusion. Pleural effusions secondary to haematological are usually lymphocyte predominant. However, several other conditions such as carcinoma, tuberculosis, and chronic heart failure also lymphocytic effusions. Lymphocyte subset (LS) analysis may be a useful test identify in patients with research into their utility effusion diagnostic algorithms has not yet been published....
Abstract Oxygen is one of the most commonly administered drugs in UK hospitals. Our quality improvement project aimed to increase safety oxygen therapy at University Hospitals Bristol NHS Foundation Trust. We rate prescribing and percentage nurses signing appropriately for titration administration. hypothesised this would result a higher patients achieving their appropriate saturations. ran on several acute medical surgical wards. tested interventions with plan, do, study, act method...
A 46-year-old woman presented with sudden onset of shortness breath and pleuritic chest pain. CT pulmonary angiogram identified a 5 cm cement embolus within the right main artery surrounding thrombus. She had undergone an L4 vertebroplasty 3 years prior to presentation for benign lytic lesion. Cement is known complication incidence rates approximately 0.9%. Management usually conservative associated morbidity mortality are low. It not whether previous could provide nidus thrombus formation.
<h3>Background and Aims</h3> The interstitial lung diseases are a heterogenous group of conditions with varying degrees inflammation fibrosis the lungs. Disruption endothelial glycocalyx (EG) subsequent vascular remodelling has been implicated in pathogenesis organ but its role pulmonary is unknown. We aimed to assess acceptability EG assessment using sublingual video-microscopy compare health between patients fibrotic-ILD healthy controls. <h3>Methods</h3> Patients age sex matched controls...
<h3>Background</h3> Nintedanib and pirfenidone are antifibrotics approved for use in interstitial lung disease (ILD). Given their significant side effect (SE) burden, regular monitoring of patient adherence, tolerability liver function tests (LFTs) throughout treatment is essential. Our implementation the Pharmacy Workforce Development South (PWDS) Clinical Prioritisation accreditation<sup>1</sup> represents an innovative expansion responsibilities pharmacy technicians managing ongoing ILD...
<h3></h3> As per Summary of Product Characteristics (SpC) there is a requirement to regularly monitor liver function tests (LFT) in patients receiving nintedanib or pirfenidone. Providing this service placing unsustainable strain on the NHS both financially and clinical time. This evaluation aimed determine timing LFT abnormalities (Bilirubin ALT/AST ALP) above SpC defined threshold 'three times upper limit normal' (3 x ULN) whether were symptomatic these abnormalities. Thirty-one...
<h3>Background</h3> Nintedanib was approved in the UK for use progressive fibrosing interstitial lung disease (PF-ILD) November 2021. The prescribing criteria were informed by PF-ILD diagnostic established INBUILD study.<sup>1</sup> To date, there has been no national evaluation of nintedanib PF-ILD. <h3>Methods</h3> Specialist ILD centres invited to take part an electronic service questionnaire September 2022. collated site summary data regarding underlying diagnosis, pulmonary function...
The foundation programme aims to provide junior doctors with a supportive and educational workplace ensure the development of safe proficient future practitioners. However, it is well-recognised that many new find first few months their profession be challenging, both clinically emotionally. Nationally, …
Cell migration is a vital process in living organisms. In particular we are interested the way that white blood cells such as neutrophils migrate during episodes of inflammation which important events working innate immune system. Migration populations many kinds can be modelled using drift-diffusion models by drawing analogies between individual agents and molecules fluid. It challenging to arrive at data-driven estimate parameters this kind process, particularly so if have time varying...