A5083291051- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- SARS-CoV-2 and COVID-19 Research
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- COVID-19 Impact on Reproduction
- Trauma Management and Diagnosis
- Emergency and Acute Care Studies
- Cell Image Analysis Techniques
- Pneumothorax, Barotrauma, Emphysema
- Phagocytosis and Immune Regulation
- SARS-CoV-2 detection and testing
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
University of Oxford
2022-2025
John Radcliffe Hospital
2022-2025
University College London
2021
Background There is an emerging understanding that coronavirus disease 2019 (COVID-19) associated with increased incidence of pneumomediastinum (PTM). We aimed to determine its among patients hospitalised COVID-19 in the UK and describe factors outcome. Methods A structured survey PTM was conducted from September 2020 February 2021. UK-wide participation solicited via respiratory research networks. Identified had severe acute syndrome 2 (SARS-CoV-2) infection radiologically proven PTM. The...
Abstract Single-cell multiomic analysis of the epigenome, transcriptome, and proteome allows for comprehensive characterization molecular circuitry that underpins cell identity state. However, holistic interpretation such datasets presents a challenge given paucity approaches systematic, joint evaluation different modalities. Here, we present Panpipes, set computational workflows designed to automate multimodal single-cell spatial transcriptomic analyses by incorporating widely-used...
Highlights•MAIT cells are recruited and activated in sterile lung injury by IFN-α IL-18•MAIT cell activity is protective against injury•MAIT promote early accumulation of CD103+ cDC1s to limit damage via DNGR-1•Human IPF data suggest a potential role for MAIT fibrosisSummaryMucosal-associated invariant T (MAIT) cells, the most abundant unconventional lung, can exhibit wide range functional responses different triggers their receptor (TCR) and/or cytokines. Their role, especially injury,...
Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional cells in lung, have been recently linked to tissue protection and repair. Their role, especially sterile lung injury, is unknown. Using single cell RNA sequencing (scRNA-seq), spectral analysis adoptive transfer a bleomycin-induced we found that bleomycin activates murine pulmonary MAIT induces an accompanying repair programme, associated with protective role against injury. drive accumulation of type 1...
Tumor mass dormancy is the key intermediate step between immune surveillance and cancer progression, yet due to its transitory nature it has been difficult capture characterize. Little understood of prevalence across types mutational background that may favor such a state. While this balance finely tuned internally by equilibrium cell proliferation death, main external factors contributing tumor are immunological angiogenic. To understand genomic cellular context in which develop, we...
Mucosal-associated invariant T (MAIT) cells are the most abundant unconventional in lung and have a recently-described function maintaining tissue homeostasis, indicating their potential role promoting pulmonary repair. It is not known what MAIT play during sterile damage, or functional consequences of repair capabilities lung. Using bleomycin-induced murine injury model, we show vivo that bleomycin challenge strongly activated induced program. cell-deficient Mr1-/- mice exhibited more...
Abstract Tumour mass dormancy is the key intermediate step between immune surveillance and cancer progression, yet due to its transitory nature it has been difficult capture characterise. Little understood of prevalence across types mutational background that may favour such a state. While this balance finely tuned internally by equilibrium cell proliferation death, main external factors contributing tumour are immunological angiogenic. To understand genomic cellular context in which...