A5024562027- Pleural and Pulmonary Diseases
- Occupational and environmental lung diseases
- Frailty in Older Adults
- Lung Cancer Diagnosis and Treatment
- Trauma Management and Diagnosis
- Pneumothorax, Barotrauma, Emphysema
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Eicosanoids and Hypertension Pharmacology
- Medical Imaging Techniques and Applications
- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- Medical Imaging and Pathology Studies
- Emergency and Acute Care Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vascular Anomalies and Treatments
- Coaching Methods and Impact
- Reconstructive Surgery and Microvascular Techniques
- Global Cancer Incidence and Screening
- COVID-19 and healthcare impacts
- Osteomyelitis and Bone Disorders Research
- Tuberous Sclerosis Complex Research
- Reflective Practices in Education
- Estrogen and related hormone effects
Pharmaron (United Kingdom)
2020-2025
North Bristol NHS Trust
2019-2024
University of Bristol
2023-2024
Aston University
2024
King's College London
2024
Azienda Ospedaliero-Universitaria di Modena
2024
University of Modena and Reggio Emilia
2024
Cardiff University
2024
National Health Service
2023
Aneurin Bevan University Health Board
2021-2022
Many neuroprotective agents have been effective in experimental stroke, yet few translated into clinical application. One reason for this may be failure to consider comorbidities/risk factors models. We shown that a naturally occurring interleukin-1 receptor antagonist (IL-1Ra) is protective against ischemic brain damage healthy animals. However, effects of IL-1Ra not determined comorbid Thus, we tested whether protects injury induced by ischemia aged JCR-LA (corpulent) rats, which...
Background There is an emerging understanding that coronavirus disease 2019 (COVID-19) associated with increased incidence of pneumomediastinum (PTM). We aimed to determine its among patients hospitalised COVID-19 in the UK and describe factors outcome. Methods A structured survey PTM was conducted from September 2020 February 2021. UK-wide participation solicited via respiratory research networks. Identified had severe acute syndrome 2 (SARS-CoV-2) infection radiologically proven PTM. The...
Lymphangioleiomyomatosis is a rare pulmonary disease affecting women of childbearing age. Whilst chylothorax well-recognized complication the condition, management strategies aren't well-defined, have low success rates and are often only available at tertiary or specialist centres. We describe case young woman referred to pleural clinic with chylous effusion found be secondary lymphangioleiomyomatosis. Initial medical was unsuccessful recurrent drainages caused significant complications....
Abstract Background There are currently no data on the relationship between frailty and mortality in pleural disease. Understanding outcomes is increasingly important for clinicians to guide decisions regarding investigation management. This study aims explore all-cause status patients with Methods In this retrospective analysis of a prospectively collected observational cohort study, outpatients presenting service at tertiary centre Bristol, UK radiologically confirmed, undiagnosed effusion...
Abstract Background Rifaquizinone (RFQ, TNP-2092) is a novel multitargeting drug conjugate in development for the treatment of serious or life-threatening bacterial infections including those caused by gram-positive pathogens that have developed acquired resistance to commonly used antibiotics and associated with medical devices. RFQ exerts its antibacterial activity inhibiting RNA polymerase, DNA gyrase, topoisomerase IV. This study evaluated absorption, metabolism, excretion following an...
Aim Secondary spontaneous pneumothorax (SSP) most commonly occurs in older patients with known underlying lung disease. Many are frail, but the effect of frailty on outcomes has not previous been explored. This study arms to evaluate association between and healthcare SSP. Methods Patients SSP were identified from national Secure Anonymised Information Linkage (SAIL) databank. Frailty status was assessed using electronic index (eFI). The primary outcome time diagnosis all-cause mortality....
Pleural disease is common, representing 5% of the acute medical workload, and its incidence rising, partly due to ageing population. Frailty an important feature little known about progression in patients with frailty pleural disease. We aimed examine effect on mortality other relevant outcomes diagnosed
Spontaneous pneumothorax is a common presentation, and there has been recent surge of research into the condition. With publication new British Thoracic Society guidelines upcoming European Respiratory guidelines, we provide concise up-to-date summary clinical learning points. In particular focus on role conservative or ambulatory management, as well treatment options for persistent air leak guidance when to refer thoracic surgeons prevention recurrence pneumothorax. Educational aims To give...
<h3>Introduction</h3> To confirm resolution of air leak after intercostal chest drain (ICD) insertion for pneumothorax, physicians may clamp the ICD to mimic removal and/or use digital suction devices quantify leak. The CLAMP project aims assess whether these strategies impact rates recurrent repeat pleural procedures, or length stay. <h3>Methods</h3> Sites were recruited via INSPIRE, UK's respiratory trainee-led research network. Patients included admitted with primary secondary spontaneous...
Abstract Introduction As the population ages, frailty is becoming more common and understanding how impacts on patient outcomes has become an integral part of clinical care. To date, there no evidence available relationship between in pleural disease. In this study we explore both malignant non-malignant disease using modified index (mFI). Methods Analysis Outpatients with will be identified from a prospectively collected single-centre UK database their data notes retrospectively analysed....
Abstract Background Frailty can impact on patient care and its assessment may improve management clinical outcomes. Pleural disease is common associated with increased mortality symptoms, but prediction of outcomes limited there currently no evidence available the relationship between frailty in these patients. This protocol describes an observational study which sets out to assess whether correlates survival morbidity patients malignant or non-malignant pleural disease. Methods Participants...
<b>Introduction:</b> Indwelling pleural catheters (IPCs) are used to manage recurrent effusions. Current IPCs usually drained by vacuum bottles that can cause pain and discomfort in some patients, especially those with non-expandable lung (NEL). A new system, Geyser (Tintron Labs), has been developed drain of all brands using an electronic pump a drainage profile designed reduce discomfort. <b>Aims:</b> To explore patient experience the system compared current IPC technique....
<title>Abstract</title> <bold>Background</bold> The prevalence of frailty is increasing as the global population ages. relationship between and poor outcomes utility indices to assess well documented. Although secondary spontaneous pneumothorax (SSP) common, there are no data evaluating in this condition. This protocol describes an observational study assessing correlation mortality, amongst other clinical outcomes, patients with SSP.<bold>Methods</bold> We will use ICD-10 NHS read codes...
The carotid artery bifurcation is a region susceptible to atherosclerosis and cardiovascular diseases. geometry of the individually unique significant differences have been correlated both age gender. Identifying geometric features that produce adverse flow patterns could enable clinicians make early assessment an individual’s risk developing disease enabling proactive management. Consequently, this study aims evaluate influence angle on arterial haemodynamics using stereoscopic particle...