A5078149854- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Transplantation: Methods and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Systemic Sclerosis and Related Diseases
- Inhalation and Respiratory Drug Delivery
- Occupational exposure and asthma
- Occupational and environmental lung diseases
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Atomic and Subatomic Physics Research
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Drug-Induced Adverse Reactions
- IL-33, ST2, and ILC Pathways
- Bone and Joint Diseases
- Neonatal Respiratory Health Research
- Obstructive Sleep Apnea Research
- Neuroendocrine Tumor Research Advances
- Respiratory and Cough-Related Research
- Pleural and Pulmonary Diseases
- Pneumothorax, Barotrauma, Emphysema
- Polyomavirus and related diseases
Kyoto University
2016-2025
Kyoto University Hospital
2014-2025
University of British Columbia
2019-2023
St. Paul's Hospital
2019-2023
St. Paul's Hospital
2020-2021
Austin Health
2021
University of British Columbia Hospital
2019
Respiratory Clinical Trials
2017
Tenri Hospital
2010-2012
Nara City Hospital
1999
Objective Our objective was to evaluate the effectiveness of combination therapy consisting low-dose corticosteroids with weekly methotrexate in patients cardiac sarcoidosis whom long-term is required. Combination selected because standard corticosteroid tends result various adverse effects and steroid-sparing have been reported. Methods This study a small open-label comparing functional changes between who received (5-15 mg/day prednisolone 6 mg/week methotrexate) alone. The comparative...
<b><i>Background:</i></b> The significance of the nutritional status in idiopathic pulmonary fibrosis (IPF) is largely unknown. Temporal body weight (BW) change, a dynamic index nutrition status, can detect malnutrition more accurately than conventional single-point mass evaluation. <b><i>Objective:</i></b> To investigate how temporal BW change influences clinical courses IPF. <b><i>Methods:</i></b> This multicenter...
Rationale: To improve disease outcomes in idiopathic pulmonary fibrosis (IPF), it is essential to understand its early pathophysiology so that can be targeted therapeutically. Objectives: Perform three-dimensional assessment of the IPF lung microstructure using stereology and multiresolution computed tomography (CT) imaging. Methods: Explanted lungs from patients with (n = 8) donor control subjects were inflated air frozen. CT scans used assess large airways. Unbiased, systematic uniform...
Matrix metalloproteinases (MMPs) are believed to be involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF), and MMP-7 has been described as a useful biomarker for IPF. However, little is known regarding significance MMP-10 This observational cohort study included 57 patients with Serum MMPs were comprehensively measured all patients, relationships between these markers both disease severity prognosis evaluated. Bronchoalveolar lavage fluid (BALF) -10 levels 19 investigate...
RationaleAnti-aminoacyl transfer RNA synthetase antibodies (anti-ARS) are a group of myositis-specific autoantibodies that detected in the sera patients with polymyositis and dermatomyositis (PM/DM) also those idiopathic interstitial pneumonias without any connective tissue disease (CTD), including PM/DM. Although we reported clinical characteristics lung anti-ARS (ARS-ILD) PM/DM, long-term prognosis ARS-ILD remains undetermined. As our previous studies revealed PM/DM was similar to...
The clinical significance of serial changes in serum biomarkers patients with idiopathic pulmonary fibrosis (IPF) remains to be established. This retrospective study was conducted clarify the associations Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) physiological indices overall mortality IPF. subjects were 75 6 month change KL-6 significantly correlated percentage predicted forced vital capacity (FVC % pred) diffusing lung for carbon monoxide (% DLCO), while SP-D only DLCO....
Radiological pleuroparenchymal fibroelastosis (PPFE) lesion is characterized by pleural thickening with associated signs of subpleural fibrosis on high-resolution computed tomography (HRCT). This study evaluated the clinical significance radiological PPFE as an isolated finding or other interstitial lung diseases (ILDs) in patients having fibrotic ILDs and registered for cadaveric transplantation (LT).This retrospective included 118 ILD LT. HRCT was assessed. The impact features...
BackgroundThe transition from normal lung anatomy to minimal and established fibrosis is an important feature of the pathology idiopathic pulmonary (IPF). The purpose this report examine molecular cellular mechanisms associated with transition.MethodsPre-operative thoracic Multidetector Computed Tomography (MDCT) scans patients severe IPF (n = 9) were used identify regions minimal(n 27) fibrosis(n 27). MDCT, Micro-CT, quantitative histology, next-generation sequencing compare 24 samples...
Abstract Background Interstitial lung abnormalities (ILAs) on CT may affect the clinical outcomes in patients with chronic obstructive pulmonary disease (COPD), but their quantification remains unestablished. This study examined whether artificial intelligence (AI)-based segmentation could be applied to identify ILAs using two COPD cohorts. Methods were diagnosed visually based Fleischner Society definition. Using an AI-based method, ground-glass opacities, reticulations, and honeycombing...
Objective The respiratory rate (RR) can be monitored continuously using a HiSanso®i, stationary oxygen concentrator with built-in sensor. To examine the efficacy of this device, we compared its performance that polysomnography in inpatient settings and home sleep apnea test (HSAT) residential for patients interstitial lung disease (ILD) chronic obstructive pulmonary (COPD). Methods flow was set at 1, 3, 5 L/min 1-3 (conditions similar to surroundings) settings. Intraclass correlation...
Abstract Oxidative stress plays a pivotal role in the pathogenesis of asthma. Aquaporin-3 (AQP3) is small transmembrane water/glycerol channel that may facilitate membrane uptake hydrogen peroxide (H 2 O ). Here we report AQP3 potentiates ovalbumin (OVA)-induced murine asthma by mediating both chemokine production from alveolar macrophages and T cell trafficking. deficient (AQP3 −/− ) mice exhibited significantly reduced airway inflammation compared to wild-type mice. Adoptive transfer...
Rationale: Although centrilobular emphysema (CLE) and paraseptal (PSE) are commonly identified on multidetector computed tomography (MDCT), little is known about the pathology associated with PSE compared that of CLE.Objectives: To assess pathological differences between CLE in chronic obstructive pulmonary disease (COPD).Methods: Air-inflated frozen lung specimens (n = 6) obtained from patients severe COPD treated by transplantation were scanned MDCT. Frozen tissue cores taken central 8)...
Quantitative computed tomography (CT) analysis has been proposed as a means of objectively assessing fibrotic interstitial pneumonia (IP) including idiopathic pulmonary fibrosis (IPF). We investigated whether percentages high-attenuation areas (HAA%) and cystic (CA%) quantified from CT images were useful indices IP.CT 74 patients with pneumonias (IPF, 36; non-specific pneumonia, 9; unclassifiable 29) analyzed via in-house computer software, which automatically calculated HAA%, CA%, mean lung...
Objectives. 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (FDG-PET/CT) was reported to be useful for monitoring immunoglobulin G4-related disease (IgG4-RD); however, a quantitative FDG-PET/CT analysis such as total lesion glycolysis (TLG) has not yet been conducted. This study aimed investigate whether TLG would correlate with serum markers in IgG4-RD, and the utility of monitoring. Methods. retrospective included 17 patients (12 men; median age, 62 years)...
Background Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology with few current treatment options. Recently, we determined an important role prostaglandin F2α (PGF2α) in by using bleomycin-induced model and found abundance PGF2α bronchoalveolar lavage fluid IPF patients. We investigated the human assessing plasma concentrations 15-keto-dihydro PGF2α, stable metabolite PGF2α. Methods measured 91 patients compared these values those controls (n = 25). further...
Objective Young patients with advanced interstitial lung disease (ILD) are potential candidates for cadaveric transplantation. This study aimed to examine clinical features, outcomes, and prognostic factors in Japanese ILD awaiting Methods We investigated the features outcomes of 77 consecutive who were referred Kyoto University Hospital subsequently actively listed transplant Japan Organ Transplant Network between 2010 2014. Results Of candidates, 33 had idiopathic pulmonary fibrosis (IPF)...
Clinical studies have investigated whether obstructive sleep apnea (OSA) can modulate bone metabolism but data are conflicting. Bone mineral density (BMD) measured by dual-energy x-ray absorptiometry is the standard technique for quantifying strength has limitations in overweight patients (body mass index [BMI] ≥ 25 kg/m(2)). The aim of this study was to examine association between OSA and BMD examining CT images that allow true volumetric measurements regardless BMI.Lumbar vertebrae...
We aimed to clarify the clinical significance of serum levels MMPs in interstitial lung disease (ILD) complicated with PM/DM (PM/DM-ILD).