A5031321349- Mycobacterium research and diagnosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberculosis Research and Epidemiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer therapeutics and mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Pneumonia and Respiratory Infections
- Phenothiazines and Benzothiazines Synthesis and Activities
- Lung Cancer Treatments and Mutations
- Asthma and respiratory diseases
- Lung Cancer Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory and Cough-Related Research
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Mycology
- Systemic Sclerosis and Related Diseases
- Medical Imaging and Pathology Studies
- Pharmacological Effects of Natural Compounds
- Quinazolinone synthesis and applications
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory Support and Mechanisms
- Leprosy Research and Treatment
- Diagnosis and treatment of tuberculosis
- Occupational exposure and asthma
- Cancer Immunotherapy and Biomarkers
Kobe City Medical Center West Hospital
2016-2025
Kobe City Medical Center General Hospital
1989-2022
Royal Prince Alfred Hospital
2021
Shimane University
1996-2011
Showa University
2009
Kobe Medical Center
1997-2008
Kobe City Nishi-Kobe Medical Center
2007
Tokyo Women's Medical University
2005
Chiba University
1989-1991
Chugai Pharma (United States)
1968-1990
<b><i>Background:</i></b> The significance of the nutritional status in idiopathic pulmonary fibrosis (IPF) is largely unknown. Temporal body weight (BW) change, a dynamic index nutrition status, can detect malnutrition more accurately than conventional single-point mass evaluation. <b><i>Objective:</i></b> To investigate how temporal BW change influences clinical courses IPF. <b><i>Methods:</i></b> This multicenter...
Newly synthesized rifamycin derivatives, KRM-1648, KRM-1657, KRM-1668, KRM-1686, and KRM-1687, having the chemical structures of 3'-hydroxy-5'-(4-alkylpiperazinyl)-benzoxazinorifamycins (alkyl residues: isobutyl, propyl, sec-butyl, sec-butyl [R configuration], [S respectively), were studied for their in vitro antimycobacterial activities. Representative (KRM-1648) MICs 90% strains tested, determined by agar dilution method on 7H11 medium, various pathogenic mycobacteria (9 species, 174...
Background Idiopathic pulmonary fibrosis (IPF) is characterised by worsening dyspnoea and exercise intolerance. Research question Does a long-term rehabilitation improve tolerance in patients with IPF treated standard antifibrotic drugs, which are expected to reduce disease progression? Methods This open-label randomised controlled trial was performed at 19 institutions. Stable receiving nintedanib were into control groups (1:1). The group underwent initial included twice-weekly sessions of...
Sex differences were observed in host resistance to Mycobacterium marinum infection mice. Males found be more susceptible than females terms of mortality, incidence gross skin lesions, and bacterial load the lungs spleen. The degree sex varied from strain test mice, order C3H/He, A/J, BALB/c greater DBA/2, B10.A, C57BL/6, on basis survival time multiplication organisms visceral organs. Although this ordering corresponded susceptibilities both male female mice organisms, much dependency was...
Reference strains of the Mycobacterium avium complex (MAC) belonging to serovars 1 28 were examined with DNA probes (Gen Probe Rapid Diagnostic System for MAC; Gen Inc., San Diego, Calif.) specific either M. or intracellulare. This study revealed that earlier designations MAC serovars, in which 3 and 4 regarded as intracellular, respectively, should be revised follows. First includes 6, 8 11, 21. Second, intracellulare 7, 12 20, 25. However, other such 22 24 26 28, involve intracellulare,...
A 20‐year‐old man was admitted with acute respiratory failure. He had started smoking 20 heat‐not‐burn cigarettes ( HC ) per day 6 months previously, then purchased a second device for to increase 40 2 weeks before hospitalization. Acute eosinophilic pneumonia AEP diagnosed based on medical history, chest high‐resolution computed tomographic findings, and bronchoalveolar lavage fluid eosinophilia. On starting treatment prednisolone, the patient exhibited complete recovery. relationship...
Background: Dyspnea and desaturation during exercise are essential assessment items for pulmonary rehabilitation. Characterizing patients using these 2 factors may be important providing more effective This study aimed to categorize subjects with interstitial lung disease (ILD) dyspnea at the end of 6-min walk test (6MWT). Methods: was a retrospective including 230 stable ILD who underwent 6MWT in our out-patient department general hospital Japan. The modified Borg scale oxygen saturation...
We attempted to identify the Mycobacterium avium complex (MAC) isolated in Japan by using DNA probes specific for M. or intracellulare (Gen-Probe Rapid Diagnostic System MAC; Gen-Probe, Inc., San Diego, Calif.). The source and drug susceptibility distributions were examined. This assay system proved be rapid, sensitive, specific, reliable identification of MAC species as either intracellulare. probe test showed that generally accepted serovars, serovars 1 6, 8 11, 21 belonged 7 12 20...
Objective: Idiopathic pulmonary fibrosis poses a significant therapeutic challenge because of its progressive course. Since oxidative stress plays an important role in the pathogenesis idiopathic fibrosis, open, randomized trial long‐term inhalation therapy with antioxidant, N‐acetylcysteine was conducted. Methodology: A total 30 patients were randomly assigned to one following therapies: (352 mg per day) or bromhexine hydrochloride (4 as control. Efficacy assessed by analysing changes...
The present study investigated whether transcranial magnetic stimulation (TMS) to the parietal cortex improves performance of healthy persons in a spatial working memory (WM) task. effect TMS on frontal was examined by measuring oxygenated hemoglobin (oxy-Hb) with near-infrared spectroscopy. Fifty-two received either 100% resting motor threshold at 5 Hz (real TMS) or sham while engaged WM task control visuospatial attention applied left right during delay period Reaction times improved task,...
SUMMARY The anti-mycobacterial activities of IFN-γ and TNF-α-treated murine peritoneal macrophages were determined. Resident pretreated with or TNF-α for 2 days infected test organisms subsequently cultured up to 7 days. First, the early-phase growth Mycobacterium tuberculosis (days 0–3) was strongly suppressed in IFN-γ-treated macrophages, progressive bacterial elimination observed. Although treatment did not affect early phase organisms, killing observed later cultivation. Second, although...
To validate the cross-sectional and longitudinal use of Medical Outcome Study Short Form 36 (SF-36) for measuring health-related quality life (HRQL) in patients with idiopathic pulmonary fibrosis (IPF).Patients were administered SF-36 concomitantly underwent laboratory physiologic tests high-resolution computed tomography (HRCT). Forty-six participated initial study, 32 who available more than one year later again these studies under same conditions.Patients IPF had significantly lower...
Abstract Background and Objective Interstitial lung disease (ILD) is progressive with high symptom burdens poor prognosis. Patients ILD need optimal palliative care to maintain their quality of life, however, few nationwide surveys have addressed for ILD. Methods A nationwide, self‐administered questionnaire was conducted. Questionnaires were sent by mail pulmonary specialists certified the Japanese Respiratory Society ( n = 3423). The current practices PC ILD, end‐of‐life communication,...
AM-1155 is a newly synthesized 6-fluoro-8-methoxy quinolone. We assessed its in vitro antimycobacterial activity using sparfloxacin (SPFX) and ofloxacin (OFLX) as comparison drugs. The MICs of these agents for various mycobacterial strains were determined by the agar dilution method with 7H11 medium. had lower 50 90% tested Mycobacterium kansasii, M. marinum, fortuitum-M. chelonae complex than SPFX OFLX, values tuberculosis, scrofulaceum, avium-M. intracellulare similar to those considerably...
The in vitro and vivo activities of a new benzoxazinorifamycin, KRM-1648 (KRM), against Mycobacterium tuberculosis were studied. MIC at which 50% the isolates are inhibited (MIC50) MIC90 KRM for 30 fresh M. measured by BACTEC 460 TB System 0.016 2 micrograms/ml, respectively. These values much lower than those rifampin (RMP), 4 >128 respectively, considerably rifabutin (RBT), 0.125 8 A correlational analysis MICs these drugs clinical revealed presence cross-resistance organisms to either...
Newly synthesized benzoxazinorifamycin, KRM-1648, was studied for its in vivo anti-Mycobacterium avium complex (MAC) activities. When the MICs were determined by agar dilution method with Middlebrook 7H11 medium, KRM-1648 exhibited similarly potent vitro antimicrobial activities against MAC isolated from AIDS and non-AIDS patients, indicating possible usefulness of AIDS-associated infections. therapeutic activity experimental murine infections induced M. intracellulare N-260 (virulent...
Liposome-entrapped rifampin (RFP) was examined for therapeutic efficacy against experimental infection induced in mice by the Mycobacterium avium complex. Intraperitoneal injections (once daily, six times weekly) of liposome-entrapped RFP led to a greater reduction bacterial growth lungs and spleen infected than did free alone. given via intramuscular or subcutaneous route failed show such an increased efficacy. entrapped lipid layer liposomal vesicles exhibited level activity similar that...
Objective Information available on the clinical features and outcomes of pneumonia in diabetic patients is limited. There are no data association between glycemic control during hospitalization mortality this population. The objective study to examine whether presence hyperglycemia admission associated with admitted hospital for pneumonia. Methods This a retrospective observational cohort adults hospitalized first time 2005 2011 358-bed community hospital. Univariate multivariate analyses...
Smoking is associated with poor health-related quality of life (HRQL); however, there are few data regarding effects smoking cessation treatment on HRQL. The purpose this study was to describe changes in HRQL after and elucidate factors influencing improvement HRQL.Smoking clinic at a 358-bed community teaching hospital Japan.We conducted prospective cohort cigarette smokers who participated 3-month programme. assessed baseline the end programme using St. George's Respiratory Questionnaire...