A5064187091- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Immunotherapy and Biomarkers
- Medical Imaging and Pathology Studies
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Lung Cancer Research Studies
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Sarcoidosis and Beryllium Toxicity Research
- Pleural and Pulmonary Diseases
- PI3K/AKT/mTOR signaling in cancer
- COVID-19 Clinical Research Studies
- Respiratory and Cough-Related Research
- Occupational and environmental lung diseases
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Peptidase Inhibition and Analysis
- Colorectal Cancer Treatments and Studies
- Immune cells in cancer
- Immune Response and Inflammation
Nagoya University
2016-2025
Fujita Health University
2023-2025
Fujita Health University Hospital
2024-2025
Nagoya University Hospital
2016-2024
Tosei General Hospital
2024
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Tokai National Higher Education and Research System
2023-2024
National Taiwan University Hospital
2021
Nagoya City University
2013-2021
The origin of fibroblasts in pulmonary fibrosis is assumed to be intrapulmonary, but their extrapulmonary and especially derivation from bone marrow (BM) progenitor cells has not been ruled out. To examine this possibility directly, adult mice were durably engrafted with BM isolated transgenic expressing enhanced GFP. Induction such chimera by endotracheal bleomycin (BLM) injection caused large numbers GFP(+) appear active fibrotic lesions, while only a few could identified control lungs....
The origin of fibroblasts in pulmonary fibrosis is assumed to be intrapulmonary, but their extrapulmonary and especially derivation from bone marrow (BM) progenitor cells has not been ruled out. To examine this possibility directly, adult mice were durably engrafted with BM isolated transgenic expressing enhanced GFP. Induction such chimera by endotracheal bleomycin (BLM) injection caused large numbers GFP+ appear active fibrotic lesions, while only a few could identified control lungs....
The pathological hallmark lesions in idiopathic pulmonary fibrosis are the fibroblastic foci, which fibroblasts thought to be involved tissue remodeling, matrix deposition, and cross-talk with alveolar epithelium. Recent evidence indicates that some may derived from bone marrow progenitors as well epithelial cells through epithelial-mesenchymal transition. To evaluate whether endothelial could represent an additional source for fibroblasts, bleomycin-induced lung was established...
Immune checkpoint inhibitors, including anti–programmed cell death-1 (PD-1) antibodies, have become promising treatments for a variety of advanced malignancies. However, these medicines can cause immune-related adverse events (irAEs), endocrinopathies. This study examined the incidence endocrine irAEs induced by nivolumab. Sixty-six patients treated with nivolumab at Nagoya University Hospital were prospectively evaluated pituitary hormones, thyroid function, antithyroid antibodies (Abs),...
ABSTRACT Background and objective Acute exacerbation (AE) is a severe complication of idiopathic pulmonary fibrosis (AE‐IPF). In 2016, an international working group revised its definition diagnostic criteria; however, few studies have assessed the frequency prognosis AE in patients with other fibrotic interstitial lung diseases (FILD). Methods We used data from 1019 consecutive disease (ILD) initially evaluated between January 2008 July 2015. All subject diagnoses were made by...
Background Several immune-related adverse events (irAEs) are reported to be associated with therapeutic efficacy of immune checkpoint inhibitors, yet whether pituitary dysfunction, a life-threatening irAE, affects overall survival (OS) in patients malignancies is unclear. This prospective study examined the association dysfunction (pituitary-irAE) OS non-small cell lung carcinoma (NSCLC) or malignant melanoma (MM). Methods A total 174 (NSCLC, 108; MM, 66) treated ipilimumab, nivolumab,...
Acute respiratory distress syndrome (ARDS) can result in a life-threatening form of failure, and established, effective pharmacotherapies are therefore urgently required. Quercetin is one the most common flavonoids found fruits vegetables, has potent anti-inflammatory anti-oxidant activities. been demonstrated to exhibit cytoprotective effects through induction heme oxygenase (HO)-1. Here, we investigated whether intratracheal administration quercetin could suppress lipopolysaccharide...
Recent advances in bronchoscopy, such as transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS), have improved the diagnostic yield of small-sized peripheral lung lesions. In some cases, however, it is difficult to obtain adequate samples for pathological diagnosis. Adequate prediction accuracy TBB EBUS-GS important before deciding whether bronchoscopy should be performed.We retrospectively reviewed 149 consecutive patients who underwent lesions (≤30 mm...
Rationale: Aspirin-exacerbated respiratory disease is characterized by severe asthma, nonsteroidal antiinflammatory drug hypersensitivity, nasal polyposis, and leukotriene overproduction. Systemic corticosteroid therapy does not completely suppress lifelong aspirin hypersensitivity. Omalizumab efficacy against aspirin-exacerbated has been investigated in a randomized manner.Objectives: To evaluate omalizumab E4 overproduction, symptoms during an oral challenge patients with using...
Abstract Background As the application of silica nanomaterials continues to expand, increasing chances its exposure human body and potential harm are anticipated. Although toxicity is assumed be affected by their physio-chemical properties, including size surface functionalization, molecular mechanisms remain unclear. We hypothesized that analysis intracellular localization particles subsequent signaling could reveal a novel determinant inflammatory response against with different...
Abstract Found in inflammatory zone (FIZZ)1, also known as resistin-like molecule α, belongs to a novel class of cysteine-rich secreted protein family, named FIZZ/resistin-like molecule, with unique tissue expression patterns. FIZZ1 is induced alveolar type II epithelial cells (AECs) bleomycin (BLM)-induced lung fibrosis, and found induce myofibroblast differentiation vitro. The objective this study was elucidate the regulation AEC pulmonary fibrosis. AECs were isolated from rat lungs...
Paraneoplastic retinopathy (PR), including cancer-associated (CAR) and melanoma-associated (MAR), is a progressive retinal disease caused by antibodies generated against neoplasms not associated with the eye. While several autoantibodies antigens have been identified, there has no known autoantibody reacting specifically bipolar cell in sera of patients PR. We previously reported that transient receptor potential cation channel, subfamily M, member 1 (TRPM1) expressed ON cells functions as...
Quercetin is a flavonoid with wide variety of cytoprotective and modulatory functions. Heme oxygenase-1 (HO-1) an inducible enzyme. Its reaction product, carbon monoxide (CO), confers cellular protection in number conditions diseases associated oxidative or inflammatory lung injury. Furthermore, quercetin was reported to be potent inducer HO-1 several cell types. We hypothesized that suppresses the production collagen fibroblasts via induction HO-1. Here, we showed transforming growth...
Rationale: Acute exacerbation during the course of idiopathic pulmonary fibrosis causes a poor prognosis. Coagulation abnormalities and endothelial damage are involved in its pathogenesis. Thrombomodulin alfa, recombinant human soluble thrombomodulin, has anticoagulant antiinflammatory effects. Several clinical studies have shown that thrombomodulin alfa may improve survival acute exacerbation.Objectives: To determine efficacy safety compared with placebo fibrosis.Methods: This randomized,...
Abstract Background Anti-programmed cell death-1 (PD-1) antibodies can cause thyroid dysfunction. However, no predictive biomarkers enabling stratification of dysfunction risk have been identified. Methods A total 209 patients treated with an anti-PD-1 antibody were evaluated for anti-thyroid at baseline and prospectively function every 6 weeks 24 after treatment initiation, then observed until the visits stopped. Thyroid ultrasonography was performed if patient positive baseline. Results Of...
Abstract Background and objective Idiopathic pulmonary fibrosis (IPF) has poor prognosis, the multidisciplinary diagnostic agreement is low. Moreover, surgical lung biopsies pose comorbidity risks. Therefore, using data from non‐invasive tests usually employed to assess interstitial diseases (ILDs), we aimed develop an automated algorithm combining deep learning machine that would be capable of detecting differentiating IPF other ILDs. Methods We retrospectively analysed consecutive patients...
Abstract Background Osimertinib—the third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)—has been widely used as a first-line treatment for patients with metastatic EGFR -mutant non-small cell lung cancer (NSCLC). Osimertinib demonstrated central nervous system activity in brain metastasis; however, its efficacy against other distant organs, including bone and liver, remains unclear. Therefore, we retrospectively analyzed the clinical of osimertinib these...